Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press28610.17650/1726-9776-2011-7-3-20-24LECTUREЛЕКЦИЯIMMUNOHISTOCHEMICAL AND MOLECULAR GENETIC PROGNOSTIC FACTORS FOR EARLY-STAGE INVASIVE BLADDER CANCERИММУНОГИСТОХИМИЧЕСКИЕ И МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ФАКТОРЫ ПРОГНОЗА ПРИ РАННИХ СТАДИЯХ ИНВАЗИВНОГО РАКА МОЧЕВОГО ПУЗЫРЯChernyshevI. V.ЧернышевИ. В.
Russian Federation
efremov.gen@yandex.ruEfremovG. D.ЕфремовГ. Д.
Russian Federation
efremov.gen@yandex.ruTertychnyiA. S.ТертычныйА. С.
Russian Federation
efremov.gen@yandex.ruPerepechinD. V.ПерепечинД. В.
Russian Federation
efremov.gen@yandex.ruResearch Institute of Urology, MoscowФГУ НИИ урологии Минздравсоцразвития России, МоскваI.M. Sechenov First Moscow Medical UniversityПервый МГМУ им. И.М. Сеченова300920117320240408201404082014https://oncourology.abvpress.ru/oncur/article/view/286

Bladder cancer (BC) is one of the most common malignancies. More than 90 % of the notified cases are morphologically diagnosed as transitional cell carcinoma; moreover, over 70 % of them are the early stages (Ta, Tis, and T1) of the disease. Patients with diagnosed T1 tumor are deemed to be the most difficult group of patients with early-stage BC. Despite the generally good prognosis of the course of this stage of BC after performed therapy, the tumor recurs in most patients and progresses to a more disseminated stage in 15–20 %. In this connection, there is a continuous search for the prognostic markers associated with the poor prognosis of the disease. A number of morphological, immunohistochemical, and molecular signs that, according to the investigators’ data, correlate with the risk for BC recurrence and progression have been identified. Nonetheless, a diagnostic testing algorithm that permits the prediction of the course of the disease from primary histological data remains to be elaborated. There should be further investigations that enable one to develop an informative panel of diagnostic and prognostic markers that allow a pathologist to correctly define the stage and prognosis of the disease and a clinician to choose an optimal treatment policy for each patient.

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