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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">282</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2009-5-4-7-12</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">INTERMITTENT HORMONE THERAPY IN PATIENTS WITH PROSTATE CANCER</article-title><trans-title-group xml:lang="ru"><trans-title>ИНТЕРМИТТИРУЮЩАЯ ГОРМОНАЛЬНАЯ ТЕРАПИЯ У БОЛЬНЫХ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Alekseyev</surname><given-names>B. Ya.</given-names></name><name xml:lang="ru"><surname>Алексеев</surname><given-names>Б. Я.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>byalekseev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nyushko</surname><given-names>K. M.</given-names></name><name xml:lang="ru"><surname>Нюшко</surname><given-names>К. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>byalekseev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">P.A. Herzen Moscow Oncological Research Institute</institution></aff><aff><institution xml:lang="ru">МНИОИ им. П.А. Герцена</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2009-12-30" publication-format="electronic"><day>30</day><month>12</month><year>2009</year></pub-date><volume>5</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>7</fpage><lpage>12</lpage><history><date date-type="received" iso-8601-date="2014-08-04"><day>04</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-04"><day>04</day><month>08</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/282">https://oncourology.abvpress.ru/oncur/article/view/282</self-uri><abstract xml:lang="en"><p>Intermittent hormone therapy (IHT) is an effective and safe hormonal method in patients with prostate cancer (PC), which is as efficacious as continuous hormone therapy. IHT substantially improves quality of life at a therapy-free interval and reduces the cost of the performed therapy. IHT  </p></abstract><trans-abstract xml:lang="ru"><p>Интермиттирующая гормональная терапия (ИГТ) является эффективным и безопасным методом гормонального воздействия у больных раком предстательной железы (РПЖ), эффективность которого не уступает постоянной гормональной терапии. Проведение ИГТ существенно улучшает качество жизни пациентов в период отсутствия терапии и снижает стоимость проводимого лечения. ИГТ может быть рекомендована при терапии больных РПЖ в различных клинических ситуациях, в том числе у пациентов с наличием отдаленных метастазов.</p><p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>prostate cancer</kwd><kwd>treatment policy</kwd><kwd>intermittent hormone therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак предстательной железы</kwd><kwd>лечебная тактика</kwd><kwd>интермиттирующая гормональная терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2007 году. М., 2009.</mixed-citation><mixed-citation xml:lang="ru">Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2007 году. М., 2009.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Huggins C., Hoges C.V. Studies on prostate cancer. The effect of castration. Cancer Res 1941;385—402.</mixed-citation><mixed-citation xml:lang="ru">Huggins C., Hoges C.V. Studies on prostate cancer. The effect of castration. Cancer Res 1941;385—402.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Bayar D.P. Studies on prostatic cancer and its treatment. NY: Lea and Febiger, 1977.</mixed-citation><mixed-citation xml:lang="ru">Bayar D.P. Studies on prostatic cancer and its treatment. NY: Lea and Febiger, 1977.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Bruchovsky N., Rennie P.S., Coldman A.J. et al. Effects of androgen withdrawal on the stem cell composition of the Shionogi carcinoma. Cancer Res 1990;50(8):2275—82.</mixed-citation><mixed-citation xml:lang="ru">Bruchovsky N., Rennie P.S., Coldman A.J. et al. Effects of androgen withdrawal on the stem cell composition of the Shionogi carcinoma. Cancer Res 1990;50(8):2275—82.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Sato N., Gleave M.E., Bruchovsky N. et al. Intermittent androgen suppression delays progression of androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumor model. J Steroid Biochem Mol Biol 1996;58(2):139—46.</mixed-citation><mixed-citation xml:lang="ru">Sato N., Gleave M.E., Bruchovsky N. et al. Intermittent androgen suppression delays progression of androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumor model. J Steroid Biochem Mol Biol 1996;58(2):139—46.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Goldenberg S.L., Bruchovsky N., Gleave M.E. et al. Intermittent androgen suppression in the treatment of prostate cancer: a preliminary report. Urology 1995;45(5):839—44.</mixed-citation><mixed-citation xml:lang="ru">Goldenberg S.L., Bruchovsky N., Gleave M.E. et al. Intermittent androgen suppression in the treatment of prostate cancer: a preliminary report. Urology 1995;45(5):839—44.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Klotz I.H., Herr H.W., Morse M.J. et al. Intermittent endocrine therapy for advanced prostate cancer. Cancer 1996;58:2546—50.</mixed-citation><mixed-citation xml:lang="ru">Klotz I.H., Herr H.W., Morse M.J. et al. Intermittent endocrine therapy for advanced prostate cancer. Cancer 1996;58:2546—50.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Goldenberg S.L., Akakura K., Bruchovsky N. et al. Effects of intermittent androgen suppression on androgen- dependent tumors. Apoptosis and serum prostate-specific antigen. Cancer 1993;71(9):2782—90.</mixed-citation><mixed-citation xml:lang="ru">Goldenberg S.L., Akakura K., Bruchovsky N. et al. Effects of intermittent androgen suppression on androgen- dependent tumors. Apoptosis and serum prostate-specific antigen. Cancer 1993;71(9):2782—90.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Pether M., Goldenberg S.L. Intermittent androgen suppression. BJU Int 2004;93(3):258—61.</mixed-citation><mixed-citation xml:lang="ru">Pether M., Goldenberg S.L. Intermittent androgen suppression. BJU Int 2004;93(3):258—61.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Prapotnich D., Cathelineau X., Rozet F. et al. A 16-year clinical experience with intermittent androgen deprivation for prostate cancer: oncological results. World J Urol 2009 [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="ru">Prapotnich D., Cathelineau X., Rozet F. et al. A 16-year clinical experience with intermittent androgen deprivation for prostate cancer: oncological results. World J Urol 2009 [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Opfermann K.J., Lai Z., Essenmacher L. et al. Intermittent hormone therapy in nonmetastatic prostate cancer. Clin Genitourin Cancer 2006;5(2):138—43.</mixed-citation><mixed-citation xml:lang="ru">Opfermann K.J., Lai Z., Essenmacher L. et al. Intermittent hormone therapy in nonmetastatic prostate cancer. Clin Genitourin Cancer 2006;5(2):138—43.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Pether M., Goldenberg S.L., Bhagirath K., Gleave M. Intermittent androgen suppression in prostate cancer: an update of the Vancouver experience. Can J Urol 2003;10(2):1809—14.</mixed-citation><mixed-citation xml:lang="ru">Pether M., Goldenberg S.L., Bhagirath K., Gleave M. Intermittent androgen suppression in prostate cancer: an update of the Vancouver experience. Can J Urol 2003;10(2):1809—14.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Lane T.M., Ansell W., Farrugia D. et al. Long-term outcomes in patients with prostate cancer managed with intermittent androgen suppression. Urol Int 2004;73(2):117—22.</mixed-citation><mixed-citation xml:lang="ru">Lane T.M., Ansell W., Farrugia D. et al. Long-term outcomes in patients with prostate cancer managed with intermittent androgen suppression. Urol Int 2004;73(2):117—22.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Hussain M., Tangen C.M., Higano C. et al. Southwest Oncology Group Trial 9346 (INT-0162). Absolute prostate-specific antigen value after androgen depriva tion is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162). J Clin Oncol 2006;24(24):3984—90.</mixed-citation><mixed-citation xml:lang="ru">Hussain M., Tangen C.M., Higano C. et al. Southwest Oncology Group Trial 9346 (INT-0162). Absolute prostate-specific antigen value after androgen depriva tion is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162). J Clin Oncol 2006;24(24):3984—90.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. De Leval J., Boca P., Yousef E. et al. Intermittent versus continuous total andro- gen blockade in the treatment of patients with advanced hormone-naive prostate cancer: results of a prospective randomized multicenter trial. Clin Prostate Cancer 2002;1(3):163—71.</mixed-citation><mixed-citation xml:lang="ru">De Leval J., Boca P., Yousef E. et al. Intermittent versus continuous total andro- gen blockade in the treatment of patients with advanced hormone-naive prostate cancer: results of a prospective randomized multicenter trial. Clin Prostate Cancer 2002;1(3):163—71.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Salonen A.J., Viitanen J., Lundstedt S. et al. Finnish multicenter study comparing intermittent to continuous androgen deprivation for advanced prostate cancer: inter- im analysis of prognostic markers affecting initial response to androgen deprivation. J Urol 2008;180(3):915—9.</mixed-citation><mixed-citation xml:lang="ru">Salonen A.J., Viitanen J., Lundstedt S. et al. Finnish multicenter study comparing intermittent to continuous androgen deprivation for advanced prostate cancer: inter- im analysis of prognostic markers affecting initial response to androgen deprivation. J Urol 2008;180(3):915—9.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Tunn U.W., Kurek R., Renneberg H. et al. Intermittent complete androgen blockade in PSA relapse after radical prostatectomy and incidental prostate can- cer. Eur Urol 1999;35 (Suppl 1): 27—31.</mixed-citation><mixed-citation xml:lang="ru">Tunn U.W., Kurek R., Renneberg H. et al. Intermittent complete androgen blockade in PSA relapse after radical prostatectomy and incidental prostate can- cer. Eur Urol 1999;35 (Suppl 1): 27—31.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Kaneko Y., Maekawa S., Arakaki R. et al. Intermittent androgen deprivation therapy may prolong the duration of andro- gen dependence of well-differentiated prostate cancer. Hinyokika Kiyo 2006;52(4):259—64.</mixed-citation><mixed-citation xml:lang="ru">Kaneko Y., Maekawa S., Arakaki R. et al. Intermittent androgen deprivation therapy may prolong the duration of andro- gen dependence of well-differentiated prostate cancer. Hinyokika Kiyo 2006;52(4):259—64.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Miller K., Steiner U., Lingnau A. et al. Randomised prospective study of intermit- tent versus continuous androgen suppression in advanced prostate cancer. J Clin Oncol 2007;1(25):18.</mixed-citation><mixed-citation xml:lang="ru">Miller K., Steiner U., Lingnau A. et al. Randomised prospective study of intermit- tent versus continuous androgen suppression in advanced prostate cancer. J Clin Oncol 2007;1(25):18.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Irani J., Celhay O., Hubert J. et al. Association for Research in Urological Oncology. Continuous versus six months a year maximal androgen blockade in the management of prostate cancer: a randomised study. Eur Urol 2008;54(2): 382—91.</mixed-citation><mixed-citation xml:lang="ru">Irani J., Celhay O., Hubert J. et al. Association for Research in Urological Oncology. Continuous versus six months a year maximal androgen blockade in the management of prostate cancer: a randomised study. Eur Urol 2008;54(2): 382—91.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Calais da Silva F.E., Bono A.V., Whelan P. et al. Intermittent androgen dep- rivation for locally advanced and metastatic prostate cancer: results from a randomised phase 3 study of the South European Uroncological Group. Eur Urol 2009;55(6):1269—77. Epub 2009 Feb 21.</mixed-citation><mixed-citation xml:lang="ru">Calais da Silva F.E., Bono A.V., Whelan P. et al. Intermittent androgen dep- rivation for locally advanced and metastatic prostate cancer: results from a randomised phase 3 study of the South European Uroncological Group. Eur Urol 2009;55(6):1269—77. Epub 2009 Feb 21.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Алексеев Б.Я. Лечение локализованного и местнораспространенного рака предстательной железы. Автореф. дис. ... докт. мед. наук. М., 2006.</mixed-citation><mixed-citation xml:lang="ru">Алексеев Б.Я. Лечение локализованного и местнораспространенного рака предстательной железы. Автореф. дис. ... докт. мед. наук. М., 2006.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. EAU Guidelines, 2009.</mixed-citation><mixed-citation xml:lang="ru">EAU Guidelines, 2009.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
