<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">272</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2009-5-3-63-67</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="ru">ЭФФЕКТИВНОСТЬ СУНИТИНИБА В ТАРГЕТНОЙ ТЕРАПИИ МЕТАСТАТИЧЕСКОГО РАКА ПОЧКИ</article-title><trans-title-group xml:lang="en"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname></surname><given-names></given-names></name><name xml:lang="ru"><surname>Калпинский</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>byalekseev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname></surname><given-names></given-names></name><name xml:lang="ru"><surname>Алексеев</surname><given-names>Б. Я.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>byalekseev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">МНИОИ им. П.А. Герцена</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2009-09-30" publication-format="electronic"><day>30</day><month>09</month><year>2009</year></pub-date><volume>5</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>63</fpage><lpage>67</lpage><history><date date-type="received" iso-8601-date="2014-08-04"><day>04</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-04"><day>04</day><month>08</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/272">https://oncourology.abvpress.ru/oncur/article/view/272</self-uri><abstract xml:lang="ru"><p>Рассмотрена эффективность сунитиниба в таргетной терапии метастатического рака почки.</p></abstract><trans-abstract xml:lang="en"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>сунитиниб</kwd><kwd>таргетная терапия</kwd><kwd>метастатический рак почки</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Keane T., Gillatt D., Evans C. P., Tubaro A. Current and future trends in treatment of renal cancer. Eur Urol Suppl 2007;6:374—84.</mixed-citation><mixed-citation xml:lang="ru">Keane T., Gillatt D., Evans C. P., Tubaro A. Current and future trends in treatment of renal cancer. Eur Urol Suppl 2007;6:374—84.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2007 году. М., 2008.</mixed-citation><mixed-citation xml:lang="ru">Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2007 году. М., 2008.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Cohen H.T., McGovern F.J. Renal-cell carcinoma. N Engl J Med 2005;353:2477—90.</mixed-citation><mixed-citation xml:lang="ru">Cohen H.T., McGovern F.J. Renal-cell carcinoma. N Engl J Med 2005;353:2477—90.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Hamdy F.C. Management of urologic malignancies. N Engl J Med 2002;247:325—9.</mixed-citation><mixed-citation xml:lang="ru">Hamdy F.C. Management of urologic malignancies. N Engl J Med 2002;247:325—9.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Ljungberg B., Hanbury D.C., Kuczyk M.A. et al. Guidelines on renal cell cancer. Eur Urol 2007;51:1502—10.</mixed-citation><mixed-citation xml:lang="ru">Ljungberg B., Hanbury D.C., Kuczyk M.A. et al. Guidelines on renal cell cancer. Eur Urol 2007;51:1502—10.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Yagoda A., Abi-Rached B., Petrylak D. Chemotherapy for advanced renal-cell carcinoma: 1983—1993. Semin Oncol 1995;22:42—60.</mixed-citation><mixed-citation xml:lang="ru">Yagoda A., Abi-Rached B., Petrylak D. Chemotherapy for advanced renal-cell carcinoma: 1983—1993. Semin Oncol 1995;22:42—60.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Eisen T., Christmas T. Сlinical progress in renal cancer. London, 2007.</mixed-citation><mixed-citation xml:lang="ru">Eisen T., Christmas T. Сlinical progress in renal cancer. London, 2007.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Motzer R.J., Masumdar M., Bacic J. et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999;17(8):2530—40.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Masumdar M., Bacic J. et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999;17(8):2530—40.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Motzer R.J., Bacik J., Murphy B.A. et al. Interferon-alpha as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002;20(1):289—96.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Bacik J., Murphy B.A. et al. Interferon-alpha as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002;20(1):289—96.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Mulders P. Continued progress in treatment of advanced renal cell carcinoma: an update on the role of Sunitinib. Eur Urol Suppl 2008;7:579—84.</mixed-citation><mixed-citation xml:lang="ru">Mulders P. Continued progress in treatment of advanced renal cell carcinoma: an update on the role of Sunitinib. Eur Urol Suppl 2008;7:579—84.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Трапезникова М.Ф., Глыбин П.А., Морозов А.П. и др. Ангиогенные факторы при почечно-клеточном раке. Онкоурология 2008;(4):82—7.</mixed-citation><mixed-citation xml:lang="ru">Трапезникова М.Ф., Глыбин П.А., Морозов А.П. и др. Ангиогенные факторы при почечно-клеточном раке. Онкоурология 2008;(4):82—7.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Motzer R.J., Michaelson M.D., Redman B.G. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24:16—24.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Michaelson M.D., Redman B.G. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24:16—24.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Motzer R.J., Rini B.I., Bukowski R.M. et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006;295:2516—24.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Rini B.I., Bukowski R.M. et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006;295:2516—24.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Motzer R.J., Michaelson M.D., Rosenberg J. et al, Sunitinib efficacy against advanced renal cell carcinoma. J Urol 2007;178:1883—7.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Michaelson M.D., Rosenberg J. et al, Sunitinib efficacy against advanced renal cell carcinoma. J Urol 2007;178:1883—7.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Motzer R.J., Hutson T.E., Tomczak P. et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115—24.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Hutson T.E., Tomczak P. et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115—24.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Figlin R.A., Hutson T.E., Tomczak P. et al. Overall survival with Sunitinib versus interferon-alfa (IFN-) as first-line treatment of metastatic renal cell carcinoma (mRCC). J Clin Oncol 2008;26(Suppl):256. Abstr. 5024.</mixed-citation><mixed-citation xml:lang="ru">Figlin R.A., Hutson T.E., Tomczak P. et al. Overall survival with Sunitinib versus interferon-alfa (IFN-) as first-line treatment of metastatic renal cell carcinoma (mRCC). J Clin Oncol 2008;26(Suppl):256. Abstr. 5024.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Motzer R.J., Michaelson M.D., Hutson T.E. Sunitinib versus interferon alfa as first-line treatment of metastatic renalcell carcinoma: updated efficacy and safety results and further analysis of prognostic factors. Eur J Cancer Suppl 2007;5:301. Abstr. 4509.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Michaelson M.D., Hutson T.E. Sunitinib versus interferon alfa as first-line treatment of metastatic renalcell carcinoma: updated efficacy and safety results and further analysis of prognostic factors. Eur J Cancer Suppl 2007;5:301. Abstr. 4509.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Kollmannsberger C., Soulieres D., Wong R. et al. Sunitinib therapy for metastatic renal cell carcinoma: recommendations for management of side effects. Can Urol Ass J 2007;1(2 Suppl):41—54.</mixed-citation><mixed-citation xml:lang="ru">Kollmannsberger C., Soulieres D., Wong R. et al. Sunitinib therapy for metastatic renal cell carcinoma: recommendations for management of side effects. Can Urol Ass J 2007;1(2 Suppl):41—54.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Gore M., Szczylik C., Porta C. et al. Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis. Eur J Cancer Suppl 2007;5:299. Abstr. 4503.</mixed-citation><mixed-citation xml:lang="ru">Gore M., Szczylik C., Porta C. et al. Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis. Eur J Cancer Suppl 2007;5:299. Abstr. 4503.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Patard J.-J. Tyrosine kinase inhibitors in clinical practice: patient selection. Eur Urol Suppl 2008;7:601—9.</mixed-citation><mixed-citation xml:lang="ru">Patard J.-J. Tyrosine kinase inhibitors in clinical practice: patient selection. Eur Urol Suppl 2008;7:601—9.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Roigas J. Clinical management of patients receiving tyrosine kinase inhibitors for advanced renal cell carcinoma. Eur Urol Suppl 2008;7:593—600.</mixed-citation><mixed-citation xml:lang="ru">Roigas J. Clinical management of patients receiving tyrosine kinase inhibitors for advanced renal cell carcinoma. Eur Urol Suppl 2008;7:593—600.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
