Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press25610.17650/1726-9776-2009-5-3-25-29PROSTATE CANCERРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫPROSTATIC INTRAEPITHELIAL NEOPLASIA: HISTOLOGICAL ASSOCIATIONSПРОСТАТИЧЕСКАЯ ИНТРАЭПИТЕЛИАЛЬНАЯ НЕОПЛАЗИЯ: ГИСТОЛОГИЧЕСКИЕ АССОЦИАЦИИGorbunovaE. N.ГорбуноваЕ. Н.
Russian Federation
iarwen@rambler.ruKrupinV. N.КрупинВ. Н.
Russian Federation
iarwen@rambler.ruDavydovaD. A.ДавыдоваД. А.
Russian Federation
iarwen@rambler.ruArtifeksovaA. A.АртифексоваА. А.
Russian Federation
iarwen@rambler.ruDepartment of Urology Nizhni Novgorod Medical Academy, Nizhni NovgorodКафедра урологии НГМА, Нижний НовгородDepartment of Morbid Anatomy, Nizhni Novgorod Medical Academy, Nizhni NovgorodКафедра патанатомии НГМА, Нижний Новгород300920095325290308201403082014https://oncourology.abvpress.ru/oncur/article/view/256

The authors determined the detection rates of prostatic intraepithelial neoplasia (PIN) in 2317 patients with benign prostatic hyperplasia (BPH) and prostate cancer (PC); and those of chronic prostatitis and fibrosis in patients with PIN, BPH, or PC. There was no difference in median age between the groups. PC was found to be more concurrent with PIN 2 than with BPH. The severer inflammation or fibrosis is, more likely there is a concomitance with PIN 2 or PC. There is evidence for the theory of inflammation is a factor of carcinogenesis. Prostatic fibrosis may also initiate carcinogenesis.

Определена частота выявления простатической интраэпителиальной неоплазии (ПИН) у 2317 пациентов с доброкачественной гиперплазией (ДГПЖ) и раком (РПЖ) предстательной железы, хронического простатита и фиброза у больных ПИН, ДГПЖ и РПЖ. Средний возраст пациентов не имеет отличий. РПЖ чаще сочетается с ПИН 2, чем ДГПЖ. Чем выраженнее воспаление или фиброз, тем вероятнее сочетание с ПИН 2 или РПЖ. Получено подтверждение теории о воспалении как факторе канцерогенеза. Фиброз предстательной железы также может инициировать канцерогенез.

benign prostate hyperplasiaprostate cancerprostatic intraepithelial neoplasiacarcinogenesisдоброкачественная гиперплазия предстательной железырак предстательной железыпростатическая интраэпителиальная неоплазияканцерогенез1. Хансон К.П., Имянитов Е.Н. Эпидемиология и биология рака предстательной железы. Практ онкол 2001;2(6):3—7.Хансон К.П., Имянитов Е.Н. Эпидемиология и биология рака предстательной железы. Практ онкол 2001;2(6):3—7.2. Переверзев А.С., Коган М.И. Рак простаты. Монография. Харьков: Факт, 2004.Переверзев А.С., Коган М.И. Рак простаты. Монография. Харьков: Факт, 2004.3. Bostwick D.G., Liu L., Brawer M.K., Qian J. High-grade prostatic intraepithelial neoplasia. Rev Urol 2004;6(4):171—9.Bostwick D.G., Liu L., Brawer M.K., Qian J. High-grade prostatic intraepithelial neoplasia. Rev Urol 2004;6(4):171—9.4. Zlotta A.R., Schulman C.C. Clinical evolution of prostatic intraepithelial neoplasia. Eur Urol 1999;35(5—6):498—503.Zlotta A.R., Schulman C.C. Clinical evolution of prostatic intraepithelial neoplasia. Eur Urol 1999;35(5—6):498—503.5. Пожарисский К.М., Воробьев А.В. Патоморфологическая характеристика и особенности карциномы предстательной железы. Значение простатической интраэпителиальной неоплазии. Практ онкол 2001;2(6): 17—23.Пожарисский К.М., Воробьев А.В. Патоморфологическая характеристика и особенности карциномы предстательной железы. Значение простатической интраэпителиальной неоплазии. Практ онкол 2001;2(6): 17—23.6. Bostwick D.G. Prostatic intraepithelial neoplasia (PIN): current concepts. J Cell Biochem Suppl 1992;16:10—9.Bostwick D.G. Prostatic intraepithelial neoplasia (PIN): current concepts. J Cell Biochem Suppl 1992;16:10—9.7. Bostwick D.G., Amin M.B., Dundore P. et al. Architectural patterns of high-grade prostatic intraepithelial neoplasia. Hum Pathol 1993;24(3):298—310.Bostwick D.G., Amin M.B., Dundore P. et al. Architectural patterns of high-grade prostatic intraepithelial neoplasia. Hum Pathol 1993;24(3):298—310.8. Bishara T., Ramnani D.M., Epstein J.I. High-grade prostatic intraepithelial neoplasia on needle biopsy: risk of cancer on repeat biopsy related to number of involved cores and morphologic pattern. Am J Surg Pathol 2004;28(5):629—33.Bishara T., Ramnani D.M., Epstein J.I. High-grade prostatic intraepithelial neoplasia on needle biopsy: risk of cancer on repeat biopsy related to number of involved cores and morphologic pattern. Am J Surg Pathol 2004;28(5):629—33.9. Billis A., Magna L.A. Inflammatory atrophy of the prostate. Prevalence and significance. Arch Pathol Lab Med 2003;127(7):840—4.Billis A., Magna L.A. Inflammatory atrophy of the prostate. Prevalence and significance. Arch Pathol Lab Med 2003;127(7):840—4.10. MacLennan G.T., Eisenberg R., Fleshman R.L. et al. The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study. J Urol 2006;176(3):1012—6.MacLennan G.T., Eisenberg R., Fleshman R.L. et al. The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study. J Urol 2006;176(3):1012—6.11. Nelson W.G., De Marzo AM., Isaacs W.B. Prostate cancer. N Engl J Med 2003;349(4):366—81.Nelson W.G., De Marzo AM., Isaacs W.B. Prostate cancer. N Engl J Med 2003;349(4):366—81.12. Palapattu G.S., Sutcliffe S., Bastian P.J. et al. Prostate carcinogenesis and inflammation: emerging insights. Carcinogenesis 2005;26(7):1170—81.Palapattu G.S., Sutcliffe S., Bastian P.J. et al. Prostate carcinogenesis and inflammation: emerging insights. Carcinogenesis 2005;26(7):1170—81.13. Dennis L.K., Lynch C.F., Torner J.C. Epidemiologic association between prostatitis and prostate cancer. Urology 2002;60(1):78—83.Dennis L.K., Lynch C.F., Torner J.C. Epidemiologic association between prostatitis and prostate cancer. Urology 2002;60(1):78—83.14. Sutcliffe S., Giovannucci E., De Marzo A.M. et al. Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;5(11):2160—6.Sutcliffe S., Giovannucci E., De Marzo A.M. et al. Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;5(11):2160—6.15. Krieger J.N., Nyberg L. Jr., Nickel J.C. NIH consensus definition and classification of prostatitis. JAMA 1999;282:236—7.Krieger J.N., Nyberg L. Jr., Nickel J.C. NIH consensus definition and classification of prostatitis. JAMA 1999;282:236—7.16. Schaeffer A.J. Chronic Prostatitis and the chronic pelvic pain syndrome. N Engl J Med 2006;355:1690—8.Schaeffer A.J. Chronic Prostatitis and the chronic pelvic pain syndrome. N Engl J Med 2006;355:1690—8.17. Carver B.S., Bozeman C.B., Williams B.J., Venable D.D. The prevalence of men with National Institutes of Health category IV prostatitis and association with serum prostate specific antigen. J Urol 2003;169:589—91.Carver B.S., Bozeman C.B., Williams B.J., Venable D.D. The prevalence of men with National Institutes of Health category IV prostatitis and association with serum prostate specific antigen. J Urol 2003;169:589—91.18. McNeal J.E. Regional morphology and pathology of the prostate. Am J Clin Path 1968;49:347—57.McNeal J.E. Regional morphology and pathology of the prostate. Am J Clin Path 1968;49:347—57.19. Terrone C., Poggio M., Bollito E. et al. Asymptomatic prostatitis: a frequent cause of raising PSA. Recenti Prog Med 2005;96(7—8):365—9.Terrone C., Poggio M., Bollito E. et al. Asymptomatic prostatitis: a frequent cause of raising PSA. Recenti Prog Med 2005;96(7—8):365—9.20. Moore R.A. Inflammation of the prostate gland. J Urol 1937;38:173—82.Moore R.A. Inflammation of the prostate gland. J Urol 1937;38:173—82.21. Maksem J.A., Johenning P.W., Galang C.F. Prostatitis and aspiration biopsy cytology of prostate. Urology 1988;32:263—8.Maksem J.A., Johenning P.W., Galang C.F. Prostatitis and aspiration biopsy cytology of prostate. Urology 1988;32:263—8.22. McClinton S., Miller I.D., Eremin O. Immunohistochemical characterization of the inflammatory cell infiltrate in benign and malignant prostate disease. Br J Cancer 1990;61:400—3.McClinton S., Miller I.D., Eremin O. Immunohistochemical characterization of the inflammatory cell infiltrate in benign and malignant prostate disease. Br J Cancer 1990;61:400—3.23. Presti B., Veidner N. Granulomatous prostatitis and poorly differentiated prostate carcinoma: their distinction with the use of immunohistochemical methods. Am J Clin Pathol 1991;95:330—4.Presti B., Veidner N. Granulomatous prostatitis and poorly differentiated prostate carcinoma: their distinction with the use of immunohistochemical methods. Am J Clin Pathol 1991;95:330—4.24. Zhang W., Sesterhenn I.A., Connelly R.R. et al. Inflammatory infiltrate (prostatitis) in whole mounted radical prostatectomy specimens from black and white patients is not etiology for racial differences in prostate specific antigen. J Urol 2000;163:131—6.Zhang W., Sesterhenn I.A., Connelly R.R. et al. Inflammatory infiltrate (prostatitis) in whole mounted radical prostatectomy specimens from black and white patients is not etiology for racial differences in prostate specific antigen. J Urol 2000;163:131—6.25. Karakiewicz P.I., Benayoun S., Begin L.R. et al. Chronic inflammation is negatively associated with prostate cancer and high-grade prostatic intraepithelial neoplasia on needle biopsy. Int J Clin Pract 2007;61(3):425—30.Karakiewicz P.I., Benayoun S., Begin L.R. et al. Chronic inflammation is negatively associated with prostate cancer and high-grade prostatic intraepithelial neoplasia on needle biopsy. Int J Clin Pract 2007;61(3):425—30.26. Irani J., Goujon J.M., Ragni E. et al. High-grade inflammation in prostate cancer as a prognostic factor for biochemical recurrence after radical prostatectomy. Pathologist Multi Center Study Group. Urology 1999;54:467—72.Irani J., Goujon J.M., Ragni E. et al. High-grade inflammation in prostate cancer as a prognostic factor for biochemical recurrence after radical prostatectomy. Pathologist Multi Center Study Group. Urology 1999;54:467—72.27. Nickel J.C., True L.D., Krieger J.N. et al. Consensus development of a histopathological classification system for chronic prostatic inflammation. BJU Int 2001;87(9):797—805.Nickel J.C., True L.D., Krieger J.N. et al. Consensus development of a histopathological classification system for chronic prostatic inflammation. BJU Int 2001;87(9):797—805.