Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press25010.17650/1726-9776-2011-7-3-136-133REVIEWОБЗОРINTRAVESICAL THERAPY FOR BLADDER CANCER: STATE-OF-THE ARTВНУТРИПУЗЫРНАЯ ТЕРАПИЯ РАКА МОЧЕВОГО ПУЗЫРЯ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫProtoshchakV. V.ПротощакВ. В.
Russian Federation
protoshakurology@mail.ruKukushkinA. V.КукушкинА. В.
Russian Federation
protoshakurology@mail.ruBabkinP. A.БабкинП. А.
Russian Federation
protoshakurology@mail.ruShestayevA. Yu.ШестаевА. Ю.
Russian Federation
protoshakurology@mail.ruKubinN. D.КубинН. Д.
Russian Federation
protoshakurology@mail.ruShpilenyaE. S.ШпиленяЕ. С.
Russian Federation
protoshakurology@mail.ruNovikovA. I.НовиковА. И.
Russian Federation
protoshakurology@mail.ruDepartment of Urology, S.M. Kirov Military Medical AcademyКафедра урологии ГОУ ВПО ВМА им. С.М. КироваDepartment of Urology and Andrology, Saint Petersburg Medical Academy of Postgraduate Education, Saint PetersburgКафедра урологии и андрологии Санкт-Петербургской медицинской академии последипломного образования, Санкт-Петербург30092011731361330308201403082014https://oncourology.abvpress.ru/oncur/article/view/250

Intravesical chemo/immunotherapy is a constituent of combination treatment for bladder cancer and widely used after transurethral resection of the tumor. The goal of intravesical therapy is to reduce the risk of a recurrence and progression of the disease, by exerting a direct cytotoxic effect on malignancy. The unique properties of the bladder make it possible to constantly improve the existing local therapy options and to develop novel ones, such as intravesical electrophoresis, local hyperthermia, gene therapy, and the use of penetrants and magnetic particles. The given review combines the physicochemical and pharmacokinetic properties of drugs, the histoarchitectonic features of the bladder, the present and future of intravesical therapy.

Внутрипузырная химио-/иммунотерапия является составной частью комплексного лечения рака мочевого пузыря и широко применяется после трансуретральной резекции опухоли. Цель интравезикальной терапии состоит в снижении риска развития рецидива и прогрессии заболевания за счет прямого цитотоксического воздействия на злокачественное новообразование. Уникальные свойства мочевого пузыря позволяют постоянно совершенствовать существующие и создавать новые методы местного лечения, такие как внутрипузырный электрофорез, локальная гипертермия, генная терапия, применение веществ-пенетрантов и магнитных частиц. Представленный обзор объединяет физико-химические свойства и фармакокинетическую характеристику лекарств, особенности гистоархитектоники мочевого пузыря, настоящее и будущее внутрипузырной терапии.

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