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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">233</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2011-7-3-47-56</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почки</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">PROGNOSTIC VALUE OF VHL GENE ALTERATION IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA</article-title><trans-title-group xml:lang="ru"><trans-title>ПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ИНАКТИВИРУЮЩИХ НАРУШЕНИЙ В ГЕНЕ VHL У БОЛЬНЫХ МЕТАСТАТИЧЕСКИМ ПОЧЕЧНО-КЛЕТОЧНЫМ РАКОМ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nosov</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Носов</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yakovleva</surname><given-names>E. S.</given-names></name><name xml:lang="ru"><surname>Яковлева</surname><given-names>Е. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedyanin</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Федянин</surname><given-names>М. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chekini</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Чекини</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sinitsyna</surname><given-names>M. N.</given-names></name><name xml:lang="ru"><surname>Синицына</surname><given-names>М. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Savelov</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Савёлов</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mikhailenko</surname><given-names>D. S.</given-names></name><name xml:lang="ru"><surname>Михайленко</surname><given-names>Д. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zaletayev</surname><given-names>D. V.</given-names></name><name xml:lang="ru"><surname>Залетаев</surname><given-names>Д. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lyubchenko</surname><given-names>L. N.</given-names></name><name xml:lang="ru"><surname>Любченко</surname><given-names>Л. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tjulandin</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Тюляндин</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nosov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences (Moscow)</institution></aff><aff><institution xml:lang="ru">РОНЦ им. Н.Н. Блохина РАМН</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Moscow Cancer Hospital №62</institution></aff><aff><institution xml:lang="ru">МГОБ № 62</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Research Center for Medical Genetics (Moscow)</institution></aff><aff><institution xml:lang="ru">Медико-генетический центр РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-09-30" publication-format="electronic"><day>30</day><month>09</month><year>2011</year></pub-date><volume>7</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>47</fpage><lpage>56</lpage><history><date date-type="received" iso-8601-date="2014-08-02"><day>02</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-02"><day>02</day><month>08</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/233">https://oncourology.abvpress.ru/oncur/article/view/233</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>metastatic renal cell carcinoma</kwd><kwd>targeted therapy</kwd><kwd>VHL gene mutation</kwd><kwd>promoter hypermethylation</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>метастатический рак почки</kwd><kwd>таргетная терапия</kwd><kwd>мутации гена VHL</kwd><kwd>гиперметилирование промотора</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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