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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">227</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2011-7-4-81-89</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE STATE-OF-THE-ART OF PROTEOMIC STUDIES OF MARKERS FOR KIDNEY CANCER (A REVIEW OF LITERATURE)</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОТЕОМНЫХ ИССЛЕДОВАНИЙ МАРКЕРОВ РАКА ПОЧКИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kovalev</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Ковалев</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>sergekov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shevchenko</surname><given-names>V. E.</given-names></name><name xml:lang="ru"><surname>Шевченко</surname><given-names>В. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>sergekov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">НИИ канцерогенеза РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-12-30" publication-format="electronic"><day>30</day><month>12</month><year>2011</year></pub-date><volume>7</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>81</fpage><lpage>89</lpage><history><date date-type="received" iso-8601-date="2014-08-02"><day>02</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-02"><day>02</day><month>08</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/227">https://oncourology.abvpress.ru/oncur/article/view/227</self-uri><abstract xml:lang="en"><p>The review covers the state-of-the-art of proteomic studies to seek and identify potential markers for kidney cancer. It considers the markers found in biological fluids and tumor tissues and those detected using the models of cultured kidney cancer cells.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре отражено современное состояние протеомных исследований по поиску и идентификации потенциальных маркеров рака почки. Рассматриваются маркеры, найденные в биологических жидкостях, опухолевой ткани, а также выявленные с использованием моделей клеточных культур рака почки.</p></trans-abstract><kwd-group xml:lang="en"><kwd>renal-cell cancer</kwd><kwd>proteomics</kwd><kwd>markers</kwd><kwd>mass spectrometry</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>почечно-клеточный рак</kwd><kwd>протеомика</kwd><kwd>маркеры</kwd><kwd>масс-спектрометрия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Ljungberg B., Cowan N.C., Hanbury D.C. et al. EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol 2010;58:398– 406.</mixed-citation><mixed-citation xml:lang="ru">Ljungberg B., Cowan N.C., Hanbury D.C. et al. EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol 2010;58:398– 406.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Заридзе Д.Г. Профилактика рака. М.: ИМА-ПРЕСС, 2009.</mixed-citation><mixed-citation xml:lang="ru">Заридзе Д.Г. Профилактика рака. М.: ИМА-ПРЕСС, 2009.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Banks R.E., Craven R.A., Harnden P. et al. Key Clinical issues in renal cancer: a challenges for proteomics. World J Urol 2007;25:37–56.</mixed-citation><mixed-citation xml:lang="ru">Banks R.E., Craven R.A., Harnden P. et al. Key Clinical issues in renal cancer: a challenges for proteomics. World J Urol 2007;25:37–56.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Nickerson M.L., Jaeger E., Shi Y. et al. Improved identification of von Hippel-Lindau gene alternations in clear cell renal tumors. Clin Cancer Res 2008;14(15):4726–34.</mixed-citation><mixed-citation xml:lang="ru">Nickerson M.L., Jaeger E., Shi Y. et al. Improved identification of von Hippel-Lindau gene alternations in clear cell renal tumors. Clin Cancer Res 2008;14(15):4726–34.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. www.hupo.org</mixed-citation><mixed-citation xml:lang="ru">www.hupo.org</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. www.hppp.org</mixed-citation><mixed-citation xml:lang="ru">www.hppp.org</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. www.hkupp.org</mixed-citation><mixed-citation xml:lang="ru">www.hkupp.org</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Hwa J.S., Park H.J., Jung J.H. et al. Identification of proteins differentially expressed in the conventional renal cell carcinoma by proteomic analysis. J Korean Med Sci 2005;20:450–5.</mixed-citation><mixed-citation xml:lang="ru">Hwa J.S., Park H.J., Jung J.H. et al. Identification of proteins differentially expressed in the conventional renal cell carcinoma by proteomic analysis. J Korean Med Sci 2005;20:450–5.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Pieper R., Gatlin C.L., McGrath A.M. et al. Characterization of the human urinary proteome: a method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics 2004;4(4):1159−74.</mixed-citation><mixed-citation xml:lang="ru">Pieper R., Gatlin C.L., McGrath A.M. et al. Characterization of the human urinary proteome: a method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics 2004;4(4):1159−74.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Lichtenfels R., Dressler S.P., Zobawa M. et al. Systematic comparative protein expression profiling of clear cell renal cell carcinoma: a pilot study based on the separation of tissue specimens by twodimensional gel electrophoresis. Mol Cell Proteomics 2009;8(12):2827−42.</mixed-citation><mixed-citation xml:lang="ru">Lichtenfels R., Dressler S.P., Zobawa M. et al. Systematic comparative protein expression profiling of clear cell renal cell carcinoma: a pilot study based on the separation of tissue specimens by twodimensional gel electrophoresis. Mol Cell Proteomics 2009;8(12):2827−42.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Tolson J., Bogumil R., Brunst E. et al. Serum protein profiling by SELDI mass spectrometry: detection of multiple variants of serum amyloid alpha in renal cancer patients. Lab Invest 2004;84:845–56.</mixed-citation><mixed-citation xml:lang="ru">Tolson J., Bogumil R., Brunst E. et al. Serum protein profiling by SELDI mass spectrometry: detection of multiple variants of serum amyloid alpha in renal cancer patients. Lab Invest 2004;84:845–56.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Siu K.W., DeSouza L.V., Scorilas A. et al. Differential protein expressions in renal cell carcinoma: new biomarker discovery by mass spectrometry. J Proteome Res 2009; 8(8):3797−807.</mixed-citation><mixed-citation xml:lang="ru">Siu K.W., DeSouza L.V., Scorilas A. et al. Differential protein expressions in renal cell carcinoma: new biomarker discovery by mass spectrometry. J Proteome Res 2009; 8(8):3797−807.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Haffey W.D., Mikhaylova O., Meller J. et al. iTRAQ proteomic identification of pVHL-dependent and -independent targets of Egln1 prolyl hydroxylase knockdown in renal carcinoma cells. Adv Enzyme Regul 2009;49(1):121−32.</mixed-citation><mixed-citation xml:lang="ru">Haffey W.D., Mikhaylova O., Meller J. et al. iTRAQ proteomic identification of pVHL-dependent and -independent targets of Egln1 prolyl hydroxylase knockdown in renal carcinoma cells. Adv Enzyme Regul 2009;49(1):121−32.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Lichtenfels R., Kellner R., Atkins D. et al. Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses. Biochim Biophys Acta 2003; 1646(1−2):21−31.</mixed-citation><mixed-citation xml:lang="ru">Lichtenfels R., Kellner R., Atkins D. et al. Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses. Biochim Biophys Acta 2003; 1646(1−2):21−31.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Kumar S., Tsai C.J., Nussinov R. Temperature range of thermodynamic stability for the native state of reversible two-state proteins. Biochemistry 2003;42(17):4864−73.</mixed-citation><mixed-citation xml:lang="ru">Kumar S., Tsai C.J., Nussinov R. Temperature range of thermodynamic stability for the native state of reversible two-state proteins. Biochemistry 2003;42(17):4864−73.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Rogers M.A., Clarke P., Noble J. et al. Proteomic profiling of urinary proteins in renal cancer by surface enhanced laser desorption ionization and neural-network analysis: identification of key issues affecting potential clinical utility. Cancer Res 2003; 63(20):6971−83.</mixed-citation><mixed-citation xml:lang="ru">Rogers M.A., Clarke P., Noble J. et al. Proteomic profiling of urinary proteins in renal cancer by surface enhanced laser desorption ionization and neural-network analysis: identification of key issues affecting potential clinical utility. Cancer Res 2003; 63(20):6971−83.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Bosso N., Chinello C., Picozzi S.C. et al. Human urine biomarkers of renal cell carcinoma evaluated by ClinProt. Proteomics Clin Appl 2008;2(7−8):1036−46.</mixed-citation><mixed-citation xml:lang="ru">Bosso N., Chinello C., Picozzi S.C. et al. Human urine biomarkers of renal cell carcinoma evaluated by ClinProt. Proteomics Clin Appl 2008;2(7−8):1036−46.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Wu D.L., Zhang W.H., Wang W.J. et al. Proteomic evaluation of urine from renal cell carcinoma using SELDI-TOF-MS and tree analysis pattern. Technol Cancer Res Treat 2008;7(3):155−60.</mixed-citation><mixed-citation xml:lang="ru">Wu D.L., Zhang W.H., Wang W.J. et al. Proteomic evaluation of urine from renal cell carcinoma using SELDI-TOF-MS and tree analysis pattern. Technol Cancer Res Treat 2008;7(3):155−60.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Sim S.H., Cairns D.A., Perkins D.N. et al. Changes in the urinary proteome postoperatively in renal cancer patients — a reflection of tumour or kidney removal? Proteomics Clin Appl 2009;3(9):1112−22.</mixed-citation><mixed-citation xml:lang="ru">Sim S.H., Cairns D.A., Perkins D.N. et al. Changes in the urinary proteome postoperatively in renal cancer patients — a reflection of tumour or kidney removal? Proteomics Clin Appl 2009;3(9):1112−22.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Omenn G.S., States D.J., Adamski M. et al. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 2005;5(13):3226−45.</mixed-citation><mixed-citation xml:lang="ru">Omenn G.S., States D.J., Adamski M. et al. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 2005;5(13):3226−45.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Hara T., Honda K., Ono M. et al. Identification of 2 serum biomarkers of renal cell carcinoma by surface enhanced laser desorption/ionization mass spectrometry. J Urol 2005;174(4):1213−7.</mixed-citation><mixed-citation xml:lang="ru">Hara T., Honda K., Ono M. et al. Identification of 2 serum biomarkers of renal cell carcinoma by surface enhanced laser desorption/ionization mass spectrometry. J Urol 2005;174(4):1213−7.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Rossi L., Martin B.M., Hortin G.L. et al. Inflammatory protein profile during systemic high dose interleukin-2 administration. Proteomics 2006;6:709–20.</mixed-citation><mixed-citation xml:lang="ru">Rossi L., Martin B.M., Hortin G.L. et al. Inflammatory protein profile during systemic high dose interleukin-2 administration. Proteomics 2006;6:709–20.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Panelli M.C., White R., Foster M. et al. Forecasting the cytokine storm following systemic interleukin (IL)-2 administration. J Transl Med 2004;2:17−30.</mixed-citation><mixed-citation xml:lang="ru">Panelli M.C., White R., Foster M. et al. Forecasting the cytokine storm following systemic interleukin (IL)-2 administration. J Transl Med 2004;2:17−30.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Sabatino M., Kim-Schulze S., Panelli M.C. et al. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J Clin Oncol 2009;27(16):2645−52.</mixed-citation><mixed-citation xml:lang="ru">Sabatino M., Kim-Schulze S., Panelli M.C. et al. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J Clin Oncol 2009;27(16):2645−52.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Vermaat J.S., van der Tweel I., Mehra N. et al. Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models. Ann Oncol 2010;21(7):1472−81.</mixed-citation><mixed-citation xml:lang="ru">Vermaat J.S., van der Tweel I., Mehra N. et al. Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models. Ann Oncol 2010;21(7):1472−81.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Xu G., Xiang C.Q., Lu Y. et al. SELDITOF-MS-based serum proteomic screening in combination with CT scan distinguishes renal cell carcinoma from benign renal tumors and healthy persons. Technol Cancer Res Treat 2009;8(3):225−30.</mixed-citation><mixed-citation xml:lang="ru">Xu G., Xiang C.Q., Lu Y. et al. SELDITOF-MS-based serum proteomic screening in combination with CT scan distinguishes renal cell carcinoma from benign renal tumors and healthy persons. Technol Cancer Res Treat 2009;8(3):225−30.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Teng P.N., Hood B.L., Sun M. et al. Differential proteomic analysis of renal cell carcinoma tissue interstitial fluid. J Proteome Res 2011;10(3):1333−42.</mixed-citation><mixed-citation xml:lang="ru">Teng P.N., Hood B.L., Sun M. et al. Differential proteomic analysis of renal cell carcinoma tissue interstitial fluid. J Proteome Res 2011;10(3):1333−42.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Minamida S., Iwamura M., Kodera Y. et al. 14-3-3 Protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid. Anal Bioanal Chem 2011;401(1):245−52.</mixed-citation><mixed-citation xml:lang="ru">Minamida S., Iwamura M., Kodera Y. et al. 14-3-3 Protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid. Anal Bioanal Chem 2011;401(1):245−52.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Klade C.S., Voss T., Krystek E. et al. Identification of tumor antigens in renal cell carcinoma by serological proteome analysis. Proteomics 2001; 1(7):890−8.</mixed-citation><mixed-citation xml:lang="ru">Klade C.S., Voss T., Krystek E. et al. Identification of tumor antigens in renal cell carcinoma by serological proteome analysis. Proteomics 2001; 1(7):890−8.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Kellner R., Lichtenfels R., Atkins D. et al. Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance. Proteomics 2002;2(12):1743−51.</mixed-citation><mixed-citation xml:lang="ru">Kellner R., Lichtenfels R., Atkins D. et al. Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance. Proteomics 2002;2(12):1743−51.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Unwin R.D., Harnden P., Pappin D. et al. Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma. Proteomics 2003;3:45–55.</mixed-citation><mixed-citation xml:lang="ru">Unwin R.D., Harnden P., Pappin D. et al. Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma. Proteomics 2003;3:45–55.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Kruger T., Schoor O., Lemmel C. et al. Lessons to be learned from primary renal cell carcinomas: novel tumor antigens and HLA ligands for immunotherapy. Cancer Immunol Immunother 2005;54:826–36.</mixed-citation><mixed-citation xml:lang="ru">Kruger T., Schoor O., Lemmel C. et al. Lessons to be learned from primary renal cell carcinomas: novel tumor antigens and HLA ligands for immunotherapy. Cancer Immunol Immunother 2005;54:826–36.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Seliger B., Fedorushchenko A., Brenner W. et al. Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration. Clin Cancer Res 2007;13(1):27−37.</mixed-citation><mixed-citation xml:lang="ru">Seliger B., Fedorushchenko A., Brenner W. et al. Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration. Clin Cancer Res 2007;13(1):27−37.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Seliger B., Menig M., Lichtenfels R. et al. Identification of markers for the selection of patients undergoing renal cell carcinomaspecific immunotherapy. Proteomics 2003;3(6):979−90.</mixed-citation><mixed-citation xml:lang="ru">Seliger B., Menig M., Lichtenfels R. et al. Identification of markers for the selection of patients undergoing renal cell carcinomaspecific immunotherapy. Proteomics 2003;3(6):979−90.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Craven R.A., Hanrahan S., Totty N. et al. Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma. Proteomics 2006;6(13):3880−93.</mixed-citation><mixed-citation xml:lang="ru">Craven R.A., Hanrahan S., Totty N. et al. Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma. Proteomics 2006;6(13):3880−93.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Szymańska K., Moore L.E., Rothman N. et al. TP53, EGFR, and KRAS mutations in relation to VHL inactivation and lifestyle risk factors in renal-cell carcinoma from central and eastern Europe. Cancer Lett 2010; 293(1):92−8.</mixed-citation><mixed-citation xml:lang="ru">Szymańska K., Moore L.E., Rothman N. et al. TP53, EGFR, and KRAS mutations in relation to VHL inactivation and lifestyle risk factors in renal-cell carcinoma from central and eastern Europe. Cancer Lett 2010; 293(1):92−8.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Nakamura E., Abreu-e-Lima P., Awakura Y. et al. Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Am J Pathol 2006;168(2):574−84.</mixed-citation><mixed-citation xml:lang="ru">Nakamura E., Abreu-e-Lima P., Awakura Y. et al. Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Am J Pathol 2006;168(2):574−84.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Aggelis V., Craven R.A., Peng J. et al. Proteomic identification of differentially expressed plasma membrane proteins in renal cell carcinoma by stable isotope labeling of a von Hippel-Lindau transfectant cell line model. Proteomics 2009;9(8):2118−30.</mixed-citation><mixed-citation xml:lang="ru">Aggelis V., Craven R.A., Peng J. et al. Proteomic identification of differentially expressed plasma membrane proteins in renal cell carcinoma by stable isotope labeling of a von Hippel-Lindau transfectant cell line model. Proteomics 2009;9(8):2118−30.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">39. Shi T., Dong F., Liou L.S. et al. Differential protein profiling in renal-cell carcinoma. Mol Carcinog 2004;40(1):47−61.</mixed-citation><mixed-citation xml:lang="ru">Shi T., Dong F., Liou L.S. et al. Differential protein profiling in renal-cell carcinoma. Mol Carcinog 2004;40(1):47−61.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">40. Perego R.A., Bianchi C., Corizzato M. et al. Primary cell cultures arising from normal kidney and renal cell carcinoma retain the proteomic profile of corresponding tissues. J Proteome Res 2005;4(5):1503−10.</mixed-citation><mixed-citation xml:lang="ru">Perego R.A., Bianchi C., Corizzato M. et al. Primary cell cultures arising from normal kidney and renal cell carcinoma retain the proteomic profile of corresponding tissues. J Proteome Res 2005;4(5):1503−10.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">41. Craven R.A., Stanley A.J., Hanrahan S. et al. Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma. Proteomics 2006;6(9):2853−64.</mixed-citation><mixed-citation xml:lang="ru">Craven R.A., Stanley A.J., Hanrahan S. et al. Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma. Proteomics 2006;6(9):2853−64.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">42. Adam P.J., Terrett J.A., Steers G. et al. CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer 2006;95(3):298−306.</mixed-citation><mixed-citation xml:lang="ru">Adam P.J., Terrett J.A., Steers G. et al. CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer 2006;95(3):298−306.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">43. Alban A., David S.O., Bjorkesten L. et al. A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics 2003;3(1):36−44.</mixed-citation><mixed-citation xml:lang="ru">Alban A., David S.O., Bjorkesten L. et al. A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics 2003;3(1):36−44.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">44. Sarto C., Marocchi A., Sanchez J.C. et al. Renal cell carcinoma and normal kidney protein expression. Electrophoresis 1997; 18(3−4):599−604.</mixed-citation><mixed-citation xml:lang="ru">Sarto C., Marocchi A., Sanchez J.C. et al. Renal cell carcinoma and normal kidney protein expression. Electrophoresis 1997; 18(3−4):599−604.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">45. Zhuang Z., Huang S., Kowalak J.A. et al. From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue. Int J Oncol 2006;28(1):103−10.</mixed-citation><mixed-citation xml:lang="ru">Zhuang Z., Huang S., Kowalak J.A. et al. From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue. Int J Oncol 2006;28(1):103−10.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">46. Bloom G.C., Eschrich S., Zhou J.X. et al. Elucidation of a protein signature discriminating six common types of adenocarcinoma. Int J Cancer 2007; 120(4):769−75.</mixed-citation><mixed-citation xml:lang="ru">Bloom G.C., Eschrich S., Zhou J.X. et al. Elucidation of a protein signature discriminating six common types of adenocarcinoma. Int J Cancer 2007; 120(4):769−75.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">47. Poznanović S., Wozny W., Schwall G.P. et al. Differential radioactive proteomic analysis of microdissected renal cell carcinoma tissue by 54 cm isoelectric focusing in serial immobilized pH gradient gels. J Proteome Res 2005;4(6):2117−25.</mixed-citation><mixed-citation xml:lang="ru">Poznanović S., Wozny W., Schwall G.P. et al. Differential radioactive proteomic analysis of microdissected renal cell carcinoma tissue by 54 cm isoelectric focusing in serial immobilized pH gradient gels. J Proteome Res 2005;4(6):2117−25.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">48. Seliger B., Lichtenfels R., Atkins D. et al. Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma. Proteomics 2005;5(10):2631−40.</mixed-citation><mixed-citation xml:lang="ru">Seliger B., Lichtenfels R., Atkins D. et al. Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma. Proteomics 2005;5(10):2631−40.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">49. Lichtenfels R., Dressler S.P., Zobawa M. et al. Systematic comparative protein expression profiling of clear cell renal cell carcinoma: a pilot study based on the separation of tissue specimens by twodimensional gel electrophoresis. Mol Cell Proteomics 2009;8(12):2827−42.</mixed-citation><mixed-citation xml:lang="ru">Lichtenfels R., Dressler S.P., Zobawa M. et al. Systematic comparative protein expression profiling of clear cell renal cell carcinoma: a pilot study based on the separation of tissue specimens by twodimensional gel electrophoresis. Mol Cell Proteomics 2009;8(12):2827−42.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">50. Kim D.S., Choi Y.P., Kang S. et al. Panel of candidate biomarkers for renal cell carcinoma. J Proteome Res 2010;9(7):3710−9.</mixed-citation><mixed-citation xml:lang="ru">Kim D.S., Choi Y.P., Kang S. et al. Panel of candidate biomarkers for renal cell carcinoma. J Proteome Res 2010;9(7):3710−9.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">51. Okamura N., Masuda T., Gotoh A. et al. Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma. Proteomics 2008;8(15):3194−203.</mixed-citation><mixed-citation xml:lang="ru">Okamura N., Masuda T., Gotoh A. et al. Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma. Proteomics 2008;8(15):3194−203.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">52. Zimmermann U., Balabanov S., Giebel J. et al. Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. Cancer Lett 2004;209(1):111−8.</mixed-citation><mixed-citation xml:lang="ru">Zimmermann U., Balabanov S., Giebel J. et al. Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. Cancer Lett 2004;209(1):111−8.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">53. Alchanati I., Nallar S.C., Sun P. et al. A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene 2006; 25(54):7138-7147.</mixed-citation><mixed-citation xml:lang="ru">Alchanati I., Nallar S.C., Sun P. et al. A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene 2006; 25(54):7138-7147.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">54. Castronovo V., Waltregny D., Kischel P. et al. A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer. Mol Cell Proteomics 2006;5(11):2083−91.</mixed-citation><mixed-citation xml:lang="ru">Castronovo V., Waltregny D., Kischel P. et al. A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer. Mol Cell Proteomics 2006;5(11):2083−91.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">55. Dorai T., Sawczuk I.S., Pastorek J. et al. The role of carbonic anhydrase IX overexpression in kidney cancer. Eur J Cancer 2005;41(18):2935−47.</mixed-citation><mixed-citation xml:lang="ru">Dorai T., Sawczuk I.S., Pastorek J. et al. The role of carbonic anhydrase IX overexpression in kidney cancer. Eur J Cancer 2005;41(18):2935−47.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">56. von Eggeling F., Junker K., Fiedle W. et al. Mass spectrometry meets chip technology: a new proteomic tool in cancer research? Electrophoresis 2001;22(14):2898−902.</mixed-citation><mixed-citation xml:lang="ru">von Eggeling F., Junker K., Fiedle W. et al. Mass spectrometry meets chip technology: a new proteomic tool in cancer research? Electrophoresis 2001;22(14):2898−902.</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">57. Junker K., Gneist J., Melle C. et al. Identification of protein pattern in kidney cancer using ProteinChip arrays and bioinformatics. Int J Mol Med 2005; 15(2):285−90.</mixed-citation><mixed-citation xml:lang="ru">Junker K., Gneist J., Melle C. et al. Identification of protein pattern in kidney cancer using ProteinChip arrays and bioinformatics. Int J Mol Med 2005; 15(2):285−90.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">58. Johann D.J. Jr., Wei B.R., Prieto D.A. et al. Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma. Anal Chem 2010;82(5):1584−8.</mixed-citation><mixed-citation xml:lang="ru">Johann D.J. Jr., Wei B.R., Prieto D.A. et al. Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma. Anal Chem 2010;82(5):1584−8.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">59. Minamida S., Iwamura M., Kodera Y. et al. Profilin 1 overexpression in renal cell carcinoma. Int J Urol 2011;18(1):63−71.</mixed-citation><mixed-citation xml:lang="ru">Minamida S., Iwamura M., Kodera Y. et al. Profilin 1 overexpression in renal cell carcinoma. Int J Urol 2011;18(1):63−71.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
