Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press21610.17650/1726-9776-2009-5-2-15-21DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫPROGNOSTIC FACTORS OF SURVIVAL IN RENAL CANCERФАКТОРЫ ПРОГНОЗА ВЫЖИВАЕМОСТИ ПРИ РАКЕ ПОЧКИSerioginA. V.СерегинА. В.
Russian Federation

Кафедра урологии и хирургической андрологии

loran@urotop.ruLoranO. B.ЛоранО. Б.
Russian Federation

Кафедра урологии и хирургической андрологии

loran@urotop.ruAshughyanV. R.АшугянВ. Р.
Russian Federation

Кафедра урологии и хирургической андрологии

loran@urotop.ruDepartment of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate EducationРМАПО, ГКБ им. С.П. Боткина, МоскваS.P. Botkin City Clinical Hospital, MoscowРМАПО, ГКБ им. С.П. Боткина, МоскваS.P. Botkin City Clinical Hospital, MoscowDepartment of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education300620095215210108201401082014https://oncourology.abvpress.ru/oncur/article/view/216

The purpose of the study was to reveal the independent anatomic, histological, and clinical factors of cancer-specific survival in patients with renal-cell carcinoma (RCC). For this, the authors retrospectively analyzed their experience with radical surgical treatments in 73 RCC patients operated on at the Department of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education, from January 1, 1999 to December 31, 2004; their outcomes have become known by the present time. There was a statistically significant correlation of cancer-specific survival with its parameters, such as pathological stage of a tumor, its maximum pathological size, differentiation grade, involvement of regional lymph nodes, venous tumor thrombosis, level of thrombocytosis, and degree of the clinical symptoms of the disease. Multivariate analysis of survival in RCC in relation to the prognostic factors could reveal odd ratios for the limit values of significant prognostic factors. The statistically significant prognostic values established in the present study, as well as the molecular factors the implication of which is being now investigated can become in future an effective addition to the TNM staging system to define indications for certain treatments and to predict survival in RCC  

renal cancercancer-specific survival rateprognosis factorsрак почкираково-специфическая выживаемостьфакторы прогноза1. Клиническая онкоурология. Под ред. проф. Б.П. Матвеева. М.: Вердана, 2003.Клиническая онкоурология. Под ред. проф. Б.П. Матвеева. М.: Вердана, 2003.2. Whelan P. The medical treatment of metastatic renal cell cancer. EAU Update Series 2003;1:237—46.Whelan P. The medical treatment of metastatic renal cell cancer. EAU Update Series 2003;1:237—46.3. Figlin RA. Renal cell carcinoma: man- agement of advanced disease. J Urol 1999;161:381—7.Figlin RA. Renal cell carcinoma: man- agement of advanced disease. J Urol 1999;161:381—7.4. Available at URL: http://www.seer.can- cer.gov/Available at URL: http://www.seer.can- cer.gov/5. Lam J.S., Shvarts O., Leppert J.T. et al. Renal cell carcinoma 2005: new frontiers in staging, prognostication and targeted molecular therapy. J Urol 2005;173: 1853—62.Lam J.S., Shvarts O., Leppert J.T. et al. Renal cell carcinoma 2005: new frontiers in staging, prognostication and targeted molecular therapy. J Urol 2005;173: 1853—62.6. Karakiewicz P.I., Lewinshtein D.J., Chun F.K.-H. et al. Tumor size improves the accuracy of TNM predictions in patients with renal cancer. Eur Urol 2006;50:521—9.Karakiewicz P.I., Lewinshtein D.J., Chun F.K.-H. et al. Tumor size improves the accuracy of TNM predictions in patients with renal cancer. Eur Urol 2006;50:521—9.7. Sobin L.H. TNM classification of malignant tumours. Ed. 6. New York: Wiley-Liss, 2002. p. 193—5.Sobin L.H. TNM classification of malignant tumours. Ed. 6. New York: Wiley-Liss, 2002. p. 193—5.8. Fuhrman S.A., Lasky L.C., Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655—63.Fuhrman S.A., Lasky L.C., Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655—63.9. Lang H., Lindner V., de Fromont M. et al. Multicenter determination of optimal interobserver agreement using the Fuhrman grading system for renal cell carcinoma: assessment of 241 patients with >15-year follow-up. Cancer 2005;103:625—9.Lang H., Lindner V., de Fromont M. et al. Multicenter determination of optimal interobserver agreement using the Fuhrman grading system for renal cell carcinoma: assessment of 241 patients with >15-year follow-up. Cancer 2005;103:625—9.10. Kim H.L., Belldegrun A.S., Freitas D.G. et al. Paraneoplastic signs and symptoms of renal cell carcinoma: implica- tions for prognosis. J Urol 2003;170: 1742—6.Kim H.L., Belldegrun A.S., Freitas D.G. et al. Paraneoplastic signs and symptoms of renal cell carcinoma: implica- tions for prognosis. J Urol 2003;170: 1742—6.11. Patard J.J., Leray E., Cindolo L. et al. Multi-institutional validation of a symp- tom-based classification for renal cell car- cinoma. J Urol 2004;172:858—62.Patard J.J., Leray E., Cindolo L. et al. Multi-institutional validation of a symp- tom-based classification for renal cell car- cinoma. J Urol 2004;172:858—62.12. Kattan M.W., Reuter V., Motzer R.J. et al. A postoperative prognostic nomogram for renal cell carcinoma. J Urol 2001;166:63—7.Kattan M.W., Reuter V., Motzer R.J. et al. A postoperative prognostic nomogram for renal cell carcinoma. J Urol 2001;166:63—7.13. Frank I., Blute M.L., Cheville J.C. et al. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol 2002;168:2395—400.Frank I., Blute M.L., Cheville J.C. et al. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol 2002;168:2395—400.14. Zisman A., Pantuck A.J., Wieder J. et al. Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol 2002;20:4559—66.Zisman A., Pantuck A.J., Wieder J. et al. Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol 2002;20:4559—66.15. Martignoni G., Brunelli M., Gobbo S. et al. Role of molecular markers in diagno- sis and prognosis of renal cell carcinoma. Anal Quant Cytol Histol 2007;29:41—9.Martignoni G., Brunelli M., Gobbo S. et al. Role of molecular markers in diagno- sis and prognosis of renal cell carcinoma. Anal Quant Cytol Histol 2007;29:41—9.16. Patard J.-J., Rioux-Leclercq N., Fergelot P. Understanding the importance of smart drugs in renal cell carcinoma. Eur Urol 2006;49:633—43.Patard J.-J., Rioux-Leclercq N., Fergelot P. Understanding the importance of smart drugs in renal cell carcinoma. Eur Urol 2006;49:633—43.17. Patard J.-J. With increasing minimally invasive options for small renal tumours, it is time to develop patient-specific treat- ment strategies. Eur Urol 2007;51: 876—8.Patard J.-J. With increasing minimally invasive options for small renal tumours, it is time to develop patient-specific treat- ment strategies. Eur Urol 2007;51: 876—8.18. Siddiqui S.A., Frank I., Leibovich B.C. et al. Impact of tumor size on the predictive ability of the pT3a primary tumor classifi- cation for renal cell carcinoma. J Urol 2007;177(1):59—62.Siddiqui S.A., Frank I., Leibovich B.C. et al. Impact of tumor size on the predictive ability of the pT3a primary tumor classifi- cation for renal cell carcinoma. J Urol 2007;177(1):59—62.19. Karakiewicz P.I., Lewinshtein D.J., Chun F.K.-H. et al. Tumor size improves the accuracy of TNM predictions in patients with renal cancer. Eur Urol 2006;5(3):5Karakiewicz P.I., Lewinshtein D.J., Chun F.K.-H. et al. Tumor size improves the accuracy of TNM predictions in patients with renal cancer. Eur Urol 2006;5(3):521—9. 20. Karakiewicz P.I., Trinh Q.-D., Bhojani N. et al. Renal cell carcinoma with nodal metastases in the absence of distant metastatic disease: prognostic indicators of disease-specific survival. Eur Urol 2007;51(6):1616—24. 21. Patard J., Rodriguez A., Rioux-Leclercq N. et al. Prognostic signifi- cance of the mode of detection in renal tumours. BJU Int 2002;90(4):358—63.—9. 20. Karakiewicz P.I., Trinh Q.-D., Bhojani N. et al. Renal cell carcinoma with nodal metastases in the absence of distant metastatic disease: prognostic indicators of disease-specific survival. Eur Urol 2007;51(6):1616—24. 21. Patard J., Rodriguez A., Rioux-Leclercq N. et al. Prognostic signifi- cance of the mode of detection in renal tumours. BJU Int 2002;90(4):358—63.2. Erdemir F., Kilciler M., Bedir S. et al. Clinical significance of platelet count in patients with renal cell carcinoma. Urol Int 2007;79(2):111—6.Erdemir F., Kilciler M., Bedir S. et al. Clinical significance of platelet count in patients with renal cell carcinoma. Urol Int 2007;79(2):111—6.23. Bensalah K., Leray E., Fergelot P. et al. Prognostic value of thrombocytosis in renal cell carcinoma. J Urol 2006;175(3 Pt 1):859—63.Bensalah K., Leray E., Fergelot P. et al. Prognostic value of thrombocytosis in renal cell carcinoma. J Urol 2006;175(3 Pt 1):859—63.