Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press192710.17650/1726-9776-2025-21-4-162-168REVIEWSОБЗОРЫReview ArticleSentinel lymph node biopsy during radical prostatectomy in patients with prostate cancer: literature reviewБиопсия сторожевых лимфатических узлов при радикальной простатэктомии у больных раком предстательной железы: обзор литературыhttps://orcid.org/0000-0002-8461-9243IzmailovA. A.ИзмайловА. А.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0009-0008-3906-6521ChaprakA. B.ЧапракА. Б.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0000-0002-7616-3899GarifullinAirat I.ГарифуллинАйрат Ильдарович
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0000-0001-5836-0066IzmailovA. A.ИзмайловА. А.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0000-0001-9142-480XKhasievA. R.ХазиевА. Р.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0009-0005-4019-9602FarganovA. R.ФаргановА. Р.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0000-0002-3627-0067AkchulpanT. Kh.АкчулпанТ. Х.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0000-0002-7562-5684GantsevK. Sh.ГанцевК. Ш.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0000-0002-8582-2526YatsenkoT. G.ЯценкоТ. Г.
Russian Federation
garifullin.airat@gmail.comhttps://orcid.org/0009-0006-5825-7484KhrizmanYu. N.ХризманЮ. Н.
Russian Federation
garifullin.airat@gmail.comRepublican Clinical Oncology Dispensary, Ministry of Health of the Republic of Bashkortostan, UfaГАУЗ «Республиканский клинический онкологический диспансер» Минздрава Республики Башкортостан, УфаBashkir State Medical University, Ministry of Health of RussiaФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РоссииMoscow City Oncology Hospital No. 62, Moscow Healthcare DepartmentГБУЗ г. Москвы «Московская городская онкологическая больница № 62 Департамента здравоохранения г. Москвы»160320262141621680304202518022026Copyright ©; 2026, Izmailov A.A., Chaprak A.B., Garifullin A.I., Izmailov A.A., Khasiev A.R., Farganov A.R., Akchulpan T.K., Gantsev K.S., Yatsenko T.G., Khrizman Y.N.Copyright ©; 2026, Измайлов А.А., Чапрак А.Б., Гарифуллин А.И., Измайлов А.А., Хазиев А.Р., Фарганов А.Р., Акчулпан Т.Х., Ганцев К.Ш., Яценко Т.Г., Хризман Ю.Н.2026Izmailov A.A., Chaprak A.B., Garifullin A.I., Izmailov A.A., Khasiev A.R., Farganov A.R., Akchulpan T.K., Gantsev K.S., Yatsenko T.G., Khrizman Y.N.Измайлов А.А., Чапрак А.Б., Гарифуллин А.И., Измайлов А.А., Хазиев А.Р., Фарганов А.Р., Акчулпан Т.Х., Ганцев К.Ш., Яценко Т.Г., Хризман Ю.Н.https://creativecommons.org/licenses/by/4.0https://oncourology.abvpress.ru/oncur/article/view/1927

Prostate cancer is one of the most frequently diagnosed oncological diseases worldwide and in the Russian Federation. Modern extended pelvic lymph node dissection is the most reliable method for detecting metastases in regional lymph nodes in patients with prostate cancer. However, this method is associated with certain risks both during the operation and in the postoperative period, which encourages researchers to develop alternative diagnostic approaches. One such alternative is sentinel lymph node biopsy, which demonstrates high potential in diagnostics. At the same time, a number of factors must be considered: limited number of randomized clinical trials, diversity of protocols used, variability of radioisotope and tracer combinations, as well as the need to consider both instrumental and clinical data. For the widespread implementation of this approach in clinical practice, further scientific research is required, including studies conducted in Russia.

Рак предстательной железы – наиболее часто встречающееся злокачественное новообразование у мужчин. Современная расширенная тазовая лимфаденэктомия на сегодняшний день является наиболее надежным методом выявления метастазов в регионарных лимфатических узлах у пациентов с данным заболеванием. Однако этот метод связан с определенными рисками и осложнениями как во время операции, так и в послеоперационном периоде, что стимулирует исследователей к разработке альтернативных диагностических подходов. Одна из таких альтернатив – биопсия сторожевых лимфатических узлов, которая демонстрирует высокий потенциал и вошла в клиническую практику при лечении рака молочной железы. При этом необходимо учитывать ряд факторов: ограниченное количество рандомизированных клинических исследований, разнообразие используемых протоколов, вариативность комбинаций радиоизотопов и трейсеров, а также необходимость учета как инструментальных, так и клинических данных. Для широкого внедрения данного подхода в клиническую практику требуется продолжение научных исследований, включая работы на территории России.

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