<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">190</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2009-5-1-34-39</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">INTRAVESICULAR IMMUNOTHERAPY WITH BCG VACCINE AND INTERFERON-αα2B FOR NON-INVASIVE CARCINOMA OF THE URINARY BLADDER: RESULTS OF PROSPECTIVE RANDOMIZED STUDY</article-title><trans-title-group xml:lang="ru"><trans-title>ВНУТРИПУЗЫРНАЯ ИММУНОТЕРАПИЯ ВАКЦИНОЙ БЦЖ И ИНТЕРФЕРОНОМ-Α2B ПРИ НЕИНВАЗИВНОМ РАКЕ МОЧЕВОГО ПУЗЫРЯ: РЕЗУЛЬТАТЫ ПРОСПЕКТИВНОГО РАНДОМИЗИРОВАННОГО ИССЛЕДОВАНИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Minich</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Минич</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sukonko</surname><given-names>O. G.</given-names></name><name xml:lang="ru"><surname>Суконко</surname><given-names>О. Г.</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rolevich</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Ролевич</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Aleksandrov Republican Research-and-Production Center of Oncology and Medical Radiology, Minsk</institution></aff><aff><institution xml:lang="ru">ГУ РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова, Минск</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2009-03-30" publication-format="electronic"><day>30</day><month>03</month><year>2009</year></pub-date><volume>5</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>34</fpage><lpage>39</lpage><history><date date-type="received" iso-8601-date="2014-07-31"><day>31</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-31"><day>31</day><month>07</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/190">https://oncourology.abvpress.ru/oncur/article/view/190</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p>Внутрипузырная иммунотерапия вакциной БЦЖ и интерфероном-α2b при неинвазивном раке мочевого пузыря: результаты проспективного рандомизированного исследования</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Kirkali Z., Chan T., Manoharan M. et al.Bladder cancer: epidemiology, staging andgrading, and diagnosis. Urology2005;66(Suppl 6A):4—34.</mixed-citation><mixed-citation xml:lang="ru">Kirkali Z., Chan T., Manoharan M. et al.Bladder cancer: epidemiology, staging andgrading, and diagnosis. Urology2005;66(Suppl 6A):4—34.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Матвеев Б.П., Фигурин К.М., Каря-кин О.Б. Рак мочевого пузыря. М.: Вер-дана, 2001.</mixed-citation><mixed-citation xml:lang="ru">Матвеев Б.П., Фигурин К.М., Каря-кин О.Б. Рак мочевого пузыря. М.: Вер-дана, 2001.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Herr H.W. Tumor progression and sur-vival of patients with high grade, noninva-sive papillary (TaG3) bladder tumors: 15-year outcome. J Urol 2000;163:60—62.</mixed-citation><mixed-citation xml:lang="ru">Herr H.W. Tumor progression and sur-vival of patients with high grade, noninva-sive papillary (TaG3) bladder tumors: 15-year outcome. J Urol 2000;163:60—62.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Wolf H., Melsen F., Pederson S.E.,Nielson K.T. Natural history of carcinomain situ of the urinary bladder. Scand J UrolNephrol 1994;157:147.</mixed-citation><mixed-citation xml:lang="ru">Wolf H., Melsen F., Pederson S.E.,Nielson K.T. Natural history of carcinomain situ of the urinary bladder. Scand J UrolNephrol 1994;157:147.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Malmstrom P.U., Busch C., Norlen B.J.Recurrence, progression, and survival inbladder cancer: a retrospective analysis of232 patients with greater than or equal to5-year follow-up. Scand J Urol Nephrol1987;21:185—95. 6. Oosterlinck W., Lobel B., Jakse G. et al.Guidelines on bladder cancer. Eur Urol2002;41:105—12.</mixed-citation><mixed-citation xml:lang="ru">Malmstrom P.U., Busch C., Norlen B.J.Recurrence, progression, and survival inbladder cancer: a retrospective analysis of232 patients with greater than or equal to5-year follow-up. Scand J Urol Nephrol1987;21:185—95. 6. Oosterlinck W., Lobel B., Jakse G. et al.Guidelines on bladder cancer. Eur Urol2002;41:105—12.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">7. Smith О., Labasky К., Cockett A. et al.Bladder cancer clinical guidelines panelsummary report on the management ofnonmuscle invasive bladder cancer (stagesTa, T1 and Tis). J Urol 1999;162:1697—701.</mixed-citation><mixed-citation xml:lang="ru">Smith О., Labasky К., Cockett A. et al.Bladder cancer clinical guidelines panelsummary report on the management ofnonmuscle invasive bladder cancer (stagesTa, T1 and Tis). J Urol 1999;162:1697—701.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">8. Sylvester R.J., van der Meijden A.P.,Lamm D.L. Intravesical bacillus Calmette-Gue’rin reduces the risk of progression inpatients with superficial bladder cancer: ameta-analysis of the published results ofrandomized clinical trials. J Urol2002;168:1964—70.</mixed-citation><mixed-citation xml:lang="ru">Sylvester R.J., van der Meijden A.P.,Lamm D.L. Intravesical bacillus Calmette-Gue’rin reduces the risk of progression inpatients with superficial bladder cancer: ameta-analysis of the published results ofrandomized clinical trials. J Urol2002;168:1964—70.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">9. Bohle A., Jocham D., Bock P.R.Intravesical bacillus Calmette-Guerin ver-sus mitomycin C for superficial bladdercancer: a formal metaanalysis of compara-tive studies on recurrence and toxicity. JUrol 2003;169:90—5.</mixed-citation><mixed-citation xml:lang="ru">Bohle A., Jocham D., Bock P.R.Intravesical bacillus Calmette-Guerin ver-sus mitomycin C for superficial bladdercancer: a formal metaanalysis of compara-tive studies on recurrence and toxicity. JUrol 2003;169:90—5.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">10. Saint F., Salomon L., Quintela L. et al.Classification, favorising factors, preven-tion and treatment of adverse side-effectsassociated with the Bacillus Calmette-Gu?rin in the treatment of superficial blad-der cancer. Ann Urol 2002;36:120—31.</mixed-citation><mixed-citation xml:lang="ru">Saint F., Salomon L., Quintela L. et al.Classification, favorising factors, preven-tion and treatment of adverse side-effectsassociated with the Bacillus Calmette-Gu?rin in the treatment of superficial blad-der cancer. Ann Urol 2002;36:120—31.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">11. Koya M., Simon M., Soloway M.Complications of intravesical therapy forurothelial cancer of the bladder. J Urol2006;175:2004—10.</mixed-citation><mixed-citation xml:lang="ru">Koya M., Simon M., Soloway M.Complications of intravesical therapy forurothelial cancer of the bladder. J Urol2006;175:2004—10.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">12. Belldegrun A., Franklin J., O’Donnell M. et al. Superficial bladdercancer: the role of interferon-alpha. J Urol1998;159:1793—98.</mixed-citation><mixed-citation xml:lang="ru">Belldegrun A., Franklin J., O’Donnell M. et al. Superficial bladdercancer: the role of interferon-alpha. J Urol1998;159:1793—98.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">13. Herr H.W., Schwalb D.M., Zhang Z.F.et al. Intravesical bacillus Calmette-Guerintherapy prevents tumor progression anddeath from superficial bladder cancer: ten-year follow-up of a prospective randomizedtrial. J Clin Oncol 1995;13:1404—16.</mixed-citation><mixed-citation xml:lang="ru">Herr H.W., Schwalb D.M., Zhang Z.F.et al. Intravesical bacillus Calmette-Guerintherapy prevents tumor progression anddeath from superficial bladder cancer: ten-year follow-up of a prospective randomizedtrial. J Clin Oncol 1995;13:1404—16.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">14. Nseyo U.O., Lamm D.L. Therapy ofsuperficial bladder cancer. Semin Oncol1996;23:598—604.</mixed-citation><mixed-citation xml:lang="ru">Nseyo U.O., Lamm D.L. Therapy ofsuperficial bladder cancer. Semin Oncol1996;23:598—604.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">15. Coplen D.E. Long-term follow-up ofpatients treated with 1 or 2, 6-week coursesof intravesical bacillus Calmette-Guerin:analysis of possible predictors of responsefree of tumor. J Urol 1990;144(3):652—7.</mixed-citation><mixed-citation xml:lang="ru">Coplen D.E. Long-term follow-up ofpatients treated with 1 or 2, 6-week coursesof intravesical bacillus Calmette-Guerin:analysis of possible predictors of responsefree of tumor. J Urol 1990;144(3):652—7.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">16. Griffiths T.R., Charlton M., Neal D.E.,Powell P.H. Treatment of carcinoma in situwith intravesical Bacillus Calmette-Guerinwithout maintenance. J Urol2002;167:2408—12.</mixed-citation><mixed-citation xml:lang="ru">Griffiths T.R., Charlton M., Neal D.E.,Powell P.H. Treatment of carcinoma in situwith intravesical Bacillus Calmette-Guerinwithout maintenance. J Urol2002;167:2408—12.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">17. Glashan R.W. A randomized controlledstudy of intravesical а-2b interferon in car-cinoma in situ of the bladder. J Urol1990;144:658—61.</mixed-citation><mixed-citation xml:lang="ru">Glashan R.W. A randomized controlledstudy of intravesical а-2b interferon in car-cinoma in situ of the bladder. J Urol1990;144:658—61.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">18. Torti P.M. Alpha-interferon in superfi-cial bladder cancer: a Northern CaliforniaOncology Group study. J Clin Oncol1988;6:476—83.</mixed-citation><mixed-citation xml:lang="ru">Torti P.M. Alpha-interferon in superfi-cial bladder cancer: a Northern CaliforniaOncology Group study. J Clin Oncol1988;6:476—83.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">19. Chodak G.W. Intravesical interferontreatment of superficial bladder cancer.Urology 1989;34:84—6.</mixed-citation><mixed-citation xml:lang="ru">Chodak G.W. Intravesical interferontreatment of superficial bladder cancer.Urology 1989;34:84—6.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">20. Downs T. Pharmacological biocompat-ibility between intravesical preparations ofBCG and interferon-alfa 2b. J Urol1997:158:2311—6.</mixed-citation><mixed-citation xml:lang="ru">Downs T. Pharmacological biocompat-ibility between intravesical preparations ofBCG and interferon-alfa 2b. J Urol1997:158:2311—6.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">21. O'Donnell M.A. Experimental andclinical evidence of enhancement of BCGefficacy by adding interferon-alpha. J Urol1997;157:383. Аbstr 1502.</mixed-citation><mixed-citation xml:lang="ru">O'Donnell M.A. Experimental andclinical evidence of enhancement of BCGefficacy by adding interferon-alpha. J Urol1997;157:383. Аbstr 1502.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">22. Esuvaranthan K., Kamaraj R., Mohan R.S. et al. A phase IIB trial of BCGcombined with interferon alpha for bladdercancer. J Urol 2000;163:152—675 [Abstr].</mixed-citation><mixed-citation xml:lang="ru">Esuvaranthan K., Kamaraj R., Mohan R.S. et al. A phase IIB trial of BCGcombined with interferon alpha for bladdercancer. J Urol 2000;163:152—675 [Abstr].</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">23. O’Donnell M.A., Krohn J., DeWolf W.C. Salvage intravesical therapywith interferon-α2b plus low dose BacillusCalmette-Guerin is effective in patientswith superficial bladder cancer in whombacillus Calmette-Guerin alone previouslyfailed. J Urol 2001;166:1300—5.</mixed-citation><mixed-citation xml:lang="ru">O’Donnell M.A., Krohn J., DeWolf W.C. Salvage intravesical therapywith interferon-α2b plus low dose BacillusCalmette-Guerin is effective in patientswith superficial bladder cancer in whombacillus Calmette-Guerin alone previouslyfailed. J Urol 2001;166:1300—5.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">24. O’Donnell M.A., Lilli K., Leopold C.et al. Interim results from a national multi-center phase II trial of combination bacillusCalmette-Guerin plus interferon alfa-2bfor superficial bladder cancer. J Urol2004;172:888—93.</mixed-citation><mixed-citation xml:lang="ru">O’Donnell M.A., Lilli K., Leopold C.et al. Interim results from a national multi-center phase II trial of combination bacillusCalmette-Guerin plus interferon alfa-2bfor superficial bladder cancer. J Urol2004;172:888—93.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">25. Joudi F.N., Smith B.J., O’Donnell M.A. et al. Final results from anational multicenter phase II trial of com-bination bacillus Calmette-Gue’rin plusinterferon alpha-2B for reducing recur-rence of superficial bladder cancer. UrolOncol 2006;24:344—8.</mixed-citation><mixed-citation xml:lang="ru">Joudi F.N., Smith B.J., O’Donnell M.A. et al. Final results from anational multicenter phase II trial of com-bination bacillus Calmette-Gue’rin plusinterferon alpha-2B for reducing recur-rence of superficial bladder cancer. UrolOncol 2006;24:344—8.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">26. O’Donnell M.A., DeWolf W.C.Bacillus Calmette-Guerin immunotherapyfor superficial bladder cancer. Newprospects for an old warhorse. Surg OncolClin N Amer 1995;4:189—92.</mixed-citation><mixed-citation xml:lang="ru">O’Donnell M.A., DeWolf W.C.Bacillus Calmette-Guerin immunotherapyfor superficial bladder cancer. Newprospects for an old warhorse. Surg OncolClin N Amer 1995;4:189—92.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">27. Keeley F.X. A comparison of the localimmune response to intravesical alpha-interferon and bacillus Calmette-Guerin(BCG) in patients with superficial bladdercancer. J Urol 1994;151:473. Аbstr 983.</mixed-citation><mixed-citation xml:lang="ru">Keeley F.X. A comparison of the localimmune response to intravesical alpha-interferon and bacillus Calmette-Guerin(BCG) in patients with superficial bladdercancer. J Urol 1994;151:473. Аbstr 983.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">28. Borden E.C., Groveman D.S., Nasu T.et al. Antiproliferative activities of interfer-ons against human bladder carcinoma celllines in vitro. J Urol 1984;132:800—4.</mixed-citation><mixed-citation xml:lang="ru">Borden E.C., Groveman D.S., Nasu T.et al. Antiproliferative activities of interfer-ons against human bladder carcinoma celllines in vitro. J Urol 1984;132:800—4.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">29. Fuchsberger N., Kubes M., Kontsek P.et al. In vitro antiproliferative effect ofinterferon alpha in solid tumors: a potentialpredictive test. Neoplasma 1993;40:293—6.</mixed-citation><mixed-citation xml:lang="ru">Fuchsberger N., Kubes M., Kontsek P.et al. In vitro antiproliferative effect ofinterferon alpha in solid tumors: a potentialpredictive test. Neoplasma 1993;40:293—6.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">30. Hawkyard S., James K., Prescott S. et al. The effects of recombinant humaninterferon-gamma on a panel of humanbladder cancer cell lines. J Urol1991;145:1078—82.</mixed-citation><mixed-citation xml:lang="ru">Hawkyard S., James K., Prescott S. et al. The effects of recombinant humaninterferon-gamma on a panel of humanbladder cancer cell lines. J Urol1991;145:1078—82.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">31. Stricker P., Pryor K., Nicholson T. et al. Bacillus Calmette-Guerin plus intrav-esical in-terferon alpha-2b in patients withsuperficial bladder cancer. Urology1996;48:957—61.</mixed-citation><mixed-citation xml:lang="ru">Stricker P., Pryor K., Nicholson T. et al. Bacillus Calmette-Guerin plus intrav-esical in-terferon alpha-2b in patients withsuperficial bladder cancer. Urology1996;48:957—61.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
