Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press1910.17650/1726-9776-2014-10-1-53-57PROSTATE CANCERРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫHIGH-RISK PROSTATE CANCER: THE ONCOLOGICAL EFFICIENCY OF RADICAL PROSTATECTOMYРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ ВЫСОКОГО РИСКА: ОНКОЛОГИЧЕСКАЯ ЭФФЕКТИВНОСТЬ РАДИКАЛЬНОЙ ПРОСТАТЭКТОМИИVeliyevE. I.ВелиевЕ. И.
Russian Federation

Кафедра урологии и хирургической андрологии

rmapo@yandex.ruSokolovE. A.СоколовЕ. А.
Russian Federation

Кафедра урологии и хирургической андрологии

rmapo@yandex.ruLoranO. B.ЛоранО. Б.
Russian Federation

Кафедра урологии и хирургической андрологии

rmapo@yandex.ruPetrovS. B.ПетровС. Б.
Russian Federation
rmapo@yandex.ruDepartment of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, MoscowГБОУ ДПО РМАПО Минздрава России, МоскваA. M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations of Russia, Saint PetersburgФГБУ «Всероссийский центр экстренной и радиационной медицины им. А. М. Никифорова» МЧС России, Санкт-Петербург3003201410153572407201424072014https://oncourology.abvpress.ru/oncur/article/view/19

Patients with high-risk prostate cancer (PC) make up a heterogeneous population who has a substantially varying benefit from surgical treatment. The long-term oncological results of radical prostatectomy (RPE) were studied in 446 high D’Amico-risk PC patients. Overall 5- and 10-year relapse-free survival (RFS) rates were 65 and 62 %; overall 10- and 15-year cancer-specific survival (CSS) rates were 92.6 and 82.6 %. Patients with the completely removed tumor located in the histologic specimen (HS) benefited most greatly from RPE. In the HS located and unlocated tumor groups, 5-year RFS rates were 79.6 and 32.7 %; 10-year CSS rates were equal to 100 and 78.6 %. The number of preoperative high risk factors had a significant impact on outcomes. In the 1, 2, and 3 risk factor groups, 5-year RFS rates were 76.7, 39, and 35.3 % and 10-year CSS rates were equal to 97.8, 85.4, and 64.2 %, respectively.

 

Больные раком предстательной железы (РПЖ) высокого риска представляют собой неоднородную популяцию с существенно различающейся эффективностью оперативного лечения. Изучены отдаленные онкологические результаты радикальной простатэктомии (РПЭ) у 446 пациентов с РПЖ высокого риска по D’Amico. Общая 5- и 10-летняя безрецидивная выживаемость (БРВ) составила 65 и 62 %, общая 10- и 15-летняя раковоспецифическая выживаемость (РСВ) – 92,6 и 82,6 %. Наибольшую пользу от РПЭ получают пациенты с полностью удаленной, локализованной в гистологическом препарате (ГП) опухолью. В группе с локализованным в ГП и нелокализованным в ГП заболеванием 5-летняя БРВ составила соответственно 79,6 и 32,7 %, 10-летняя РСВ  – 100 и 78,6 %. Существенное влияние на исходы оказывает количество предоперационных факторов высокого риска. Пятилетняя БРВ составила 76,7; 39,0 и 35,3 % в группах с 1, 2 и 3 факторами риска, 10-летняя РСВ – соответственно 97,8; 85,4 и 64,2 %.

 

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