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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1891</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2025-21-2-138-144</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL NOTES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Ewing sarcoma: Clinical case and literature review</article-title><trans-title-group xml:lang="ru"><trans-title>Саркома Юинга почки: клинический случай и обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3095-0088</contrib-id><name-alternatives><name xml:lang="en"><surname>Zarenkova</surname><given-names>A. K.</given-names></name><name xml:lang="ru"><surname>Заренкова</surname><given-names>А. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Anastasiya Konstantinovna Zarenkova </bold></p><p><italic>24 Kashirskoe Shosse, Moscow 115522</italic></p></bio><bio xml:lang="ru"><p><bold>Анастасия Константиновна Заренкова, </bold>врач-онколог</p><p><italic>115522 Москва, Каширское шоссе, 24</italic></p></bio><email>nastua-zar@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8773-731X</contrib-id><name-alternatives><name xml:lang="en"><surname>Salimzyanov</surname><given-names>F. I.</given-names></name><name xml:lang="ru"><surname>Салимзянов</surname><given-names>Ф. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>24 Kashirskoe Shosse, Moscow 115522</italic></p></bio><bio xml:lang="ru"><p><bold>Фарит Иршатович Салимзянов, </bold>клинический ординатор</p><p><italic>115522 Москва, Каширское шоссе, 24</italic></p></bio><email>salimzyanov2996@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4754-2352</contrib-id><contrib-id contrib-id-type="spin">1128-1343</contrib-id><name-alternatives><name xml:lang="en"><surname>Abramov</surname><given-names>M. E.</given-names></name><name xml:lang="ru"><surname>Абрамов</surname><given-names>М. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>24 Kashirskoe Shosse, Moscow 115522</italic></p></bio><bio xml:lang="ru"><p><bold>Михаил Евгеньевич Абрамов, </bold>к.м.н., старший научный сотрудник онкологического отделения лекарственных методов лечения (химиотерапевтического) №4, врач-онколог</p><p><italic>115522 Москва, Каширское шоссе, 24</italic></p></bio><email>abramovm67@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7382-8568</contrib-id><name-alternatives><name xml:lang="en"><surname>Gileva</surname><given-names>M. S.</given-names></name><name xml:lang="ru"><surname>Гилева</surname><given-names>М. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>24 Kashirskoe Shosse, Moscow 115522</italic></p></bio><bio xml:lang="ru"><p><bold>Маргарита Сергеевна Гилева, </bold>клинический ординатор</p><p><italic>115522 Москва, Каширское шоссе, 24</italic></p></bio><email>gileva.rita@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4626-1295</contrib-id><name-alternatives><name xml:lang="en"><surname>Firsov</surname><given-names>K. A.</given-names></name><name xml:lang="ru"><surname>Фирсов</surname><given-names>К. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>24 Kashirskoe Shosse, Moscow 115522</italic></p></bio><bio xml:lang="ru"><p><bold>Константин Андреевич Фирсов, </bold>к.м.н., врач-онколог</p><p><italic>115522 Москва, Каширское шоссе, 24</italic></p></bio><email>leneror@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4443-9974</contrib-id><contrib-id contrib-id-type="spin">9536-3474</contrib-id><name-alternatives><name xml:lang="en"><surname>Rumyantsev</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Румянцев</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>24 Kashirskoe Shosse, Moscow 115522</italic></p></bio><bio xml:lang="ru"><p><bold>Алексей Александрович Румянцев, </bold>к.м.н., заведующий онкологического отделения лекарственных методов лечения (химиотерапевтическое) №4</p><p><italic>115522 Москва, Каширское шоссе, 24</italic></p></bio><email>alexeymma@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-08-06" publication-format="electronic"><day>06</day><month>08</month><year>2025</year></pub-date><volume>21</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>138</fpage><lpage>144</lpage><history><date date-type="received" iso-8601-date="2025-02-01"><day>01</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-05-30"><day>30</day><month>05</month><year>2025</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/1891">https://oncourology.abvpress.ru/oncur/article/view/1891</self-uri><abstract xml:lang="en"><p>This article presents a clinical case of treatment of a female patient with Ewing Sarcoma of the kidney. Currently, treatment standards haven’t yet been developed due to the rarity of this pathology. We describe our own experience of drug treatment of Ewing sarcoma of the kidney recurrence after surgery.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен клинический случай лечения пациентки с саркомой Юинга почки. В силу редкости этой патологии на настоящий момент стандартов лечения не разработано. Нами описан собственный опыт лекарственного лечения рецидива саркомы Юинга почки после хирургического этапа.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Ewing sarcoma</kwd><kwd>kidney</kwd><kwd>EWSR1-FLI1</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>саркома Юинга</kwd><kwd>почка</kwd><kwd>EWSR1-FLI1</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Seemayer T.A., Thelmo W.L., Bolande R.P. et al. Peripheral neuroectodermal tumors. Perspect Pediatr Pathol. 1975;2:151–72. PMID: 1129029.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Bing Z., Zhang P., Tomaszewski J.E. et al. Primary Ewing sarcoma/ primitive neuroectodermal tumor of the kidney. J Urol 2009;181(3):1341–2. DOI: 10.1016/j.juro.2008.12.029</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Strauss S.J., Frezza A.M., Abecassis N. et al. Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 2021;32(12):1520–36. DOI: 10.1016/j.annonc.2021.08.1995</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Geens L., Robays J.V., Geert V. et al. An unusual location of extraosseous Ewing’s sarcoma. Case Rep Oncol 2013;6(2): 293–302. DOI: 10.1159/000351836</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Xiao Y., Zhi Y., Cao G. et al. Primary Ewing’s sarcoma of the uterine cervix: a case report and review of the literature. J Cancer Res Clin Oncol 2024;150(5):267. DOI: 10.1007/s00432-024-05698-2</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Krouma M., Farah K., Choucha A. et al. Primary intradural Extraosseous Ewing’s sarcoma of the cauda equina: a case report and literature review. Neurochirurgie 2024;70(4):101562. DOI: 10.1016/j.neuchi.2024.101562</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Juan L., Jianqun Y., Fanglan L. Rare origin – Ewing’s sarcoma of the pleura: a case report and literature review. J Radiol Case Rep 2023;17(10):21–5. DOI: 10.3941/jrcr.v17i8.5187</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Rachapudi S., Srinivasan A., Gorman B. et al. Ewing’s sarcoma of the male external genitalia: a case report and review of the literature. BMC Urol 2022;22(1):121. DOI: 10.1186/s12894-022-01072-x</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Sethi P., Singh A., Srinivas B.H. et al. Practical approach in management of extraosseous Ewing’s sarcoma of head and neck: a case series and review of literature. Gulf J Oncolog 2022;1(39):79–88. PMID: 35695350.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Cheng L., Xu Y., Song H. et al. A rare entity of primary Ewing sarcoma in kidney. BMC Surg 2020;20(1):280. DOI: 10.1186/s12893-020-00948-9</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Esiashvili N., Goodman M., Marcus R.B. Jr. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: surveillance epidemiology and end results data. J Pediatr Hematol Oncol 2008;30(6):425–30. DOI: 10.1097/MPH.0b013e31816e22f3</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Tarek N., Said R., Andersen C.R. et al. Primary Ewing sarcoma/ primitive neuroectodermal tumor of the kidney: the MD Anderson Cancer Center experience. Cancers (Basel) 2020;12(10):2927. DOI: 10.3390/cancers12102927</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Risi E., Iacovelli R., Altavilla A. et al. Clinical and pathological features of primary neuroectodermal tumor/Ewing sarcoma of the kidney. Urology 2013;82(2):382–6. DOI: 10.1016/j.urology.2013.04.015</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Lalwani N., Prasad S.R., Vikram R. et al. Pediatric and adult primary sarcomas of the kidney: a cross-sectional imaging review. Acta Radiol 2011;52(4):448–57. DOI: 10.1258/ar.2011.100376</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Rossi S., Orvieto E., Furlanetto A. et al. Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody. Mod Pathol 2004;17(5):547–52. DOI: 10.1038/modpathol.3800065</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Sorensen P.H., Lessnick S.L., Lopez-Terrada D. et al. A second Ewing’s sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 1994;6(2):146–51. DOI: 10.1038/ng0294-146</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Galyfos G., Karantzikos G.A., Kavouras N. et al. Extraosseous Ewing sarcoma: diagnosis, prognosis and optimal management. Indian J Surg 2016;78(1):49–53. DOI: 10.1007/s12262-015-1399-0</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Das S., Aggarwal G., Gupta S. et al. Primary renal Ewing’s sarcoma in an adult: an enigma. Innov Surg Sci 2021;6(1):20200022. DOI: 10.1515/iss-2020-0022</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Kuczynski A.P., Gugelmin E.S., Netto R.A. Tumor primitivo neuroectodérmico de rim em criança [Primitive neuroectodermal tumor of the kidney in children]. J Pediatr (Rio J) 2001;77(1):49–51. DOI: 10.2223/jped.111</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Jimenez R.E., Folpe A.L., Lapham R.L. et al. Primary Ewing’s sarcoma/ primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol 2002;26(3):320–7. DOI: 10.1097/00000478-200203000-00005</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Bradford K., Nobori A., Johnson B. et al. Primary renal Ewing sarcoma in children and young adults. J Pediatr Hematol Oncol 2020;42(8):474–81. DOI: 10.1097/MPH.0000000000001804</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Abboud A., Masrouha K., Saliba M. et al. Extraskeletal Ewing sarcoma: diagnosis, management and prognosis. Oncol Lett 2021;21(5):354. DOI: 10.3892/ol.2021.12615</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Krasin M.J., Davidoff A.M., Rodriguez-Galindo C. et al. Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors. Cancer 2005;104(2):367–73. DOI: 10.1002/cncr.21160</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Krasin M.J., Rodriguez-Galindo C., Davidoff A.M. et al. Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumors. Pediatr Blood Cancer 2004;43(3):229–36. DOI: 10.1002/pbc.20095</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Laskar S., Sinha S., Chatterjee A. et al. Radiation therapy dose escalation in unresectable Ewing sarcoma: final results of a phase 3 randomized controlled trial. Int J Radiat Oncol Biol Phys 2022;113(5):996–1002. DOI: 10.1016/j.ijrobp.2022.04.024</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>El Weshi A., Allam A., Ajarim D. et al. Extraskeletal Ewing’s sarcoma family of tumours in adults: analysis of 57 patients from a single institution. Clin Oncol (R Coll Radiol) 2010;22(5):374–81. DOI: 10.1016/j.clon.2010.02.010</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Grier H.E., Krailo M.D., Tarbell N.J. et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003;348(8):694–701. DOI: 10.1056/NEJMoa020890</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Le Deley M.C., Paulussen M., Lewis I. et al. Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. J Clin Oncol 2014;32(23):2440–8. DOI: 10.1200/JCO.2013.54.4833</mixed-citation></ref></ref-list></back></article>
