Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press18210.17650/1726-9776-2011-7-4-12-15LECTUREЛЕКЦИЯINTERMITTENT HORMONE THERAPY IN PATIENTS WITH PROSTATE CANCERИНТЕРМИТТИРУЮЩАЯ ГОРМОНАЛЬНАЯ ТЕРАПИЯ У БОЛЬНЫХ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫAlekseyevB. Ya.АлексеевБ. Я.
Russian Federation
byalekseev@mail.ruNyushkoK. M.НюшкоК. М.
Russian Federation
byalekseev@mail.ruP.A. Herzen Moscow Oncology Research Institute, MoscowМНИОИ им. П.А. Герцена, Москва301220117412153007201430072014https://oncourology.abvpress.ru/oncur/article/view/182

Prostate cancer (PC) is a topical problem of oncourology because of the steady rise in morbidity worldwide. Despite the introduction of a diagnostic technique using prostate-specific antigen, the detection rate of the disease in its late stages remains high. Hormone therapy (HT) is considered to be a basic treatment in patients with metastatic PC. At the same time continuous HT is associated with the risk of developing side effects and can lower quality of life in the patients. Intermittent HT makes it possible to substantially reduce the cost of the performed therapy and to improve quality of life, without decreasing the efficiency of HT. The paper presents a review of clinical trials demonstrating the efficiency of intermittent HT, including the use of luteinizing hormone-releasing hormone analogues, in patients with PC.

Рак предстательной железы (РПЖ) представляет актуальную проблему онкоурологии по причине неуклонного роста показателей заболеваемости во всем мире. Несмотря на внедрение метода диагностики с помощью простатспецифического антигена, выявляемость данного заболевания на поздних стадиях остается высокой. Гормональная терапия (ГТ) считается основным методом лечения больных метастатическим РПЖ. В то же время постоянная ГТ ассоциирована с риском развития побочных эффектов и может снизить качество жизни больных. Метод интермиттирующей (прерывистой) ГТ позволяет существенно снизить стоимость проводимого лечения, улучшить качество жизни больных без снижения эффективности гормонального воздействия. В статье представлен обзор клинических исследований, продемонстрировавших эффективность и безопасность интермиттирующей ГТ у больных РПЖ, в том числе с использованием аналогов лютеинизирующего гормона рилизинг-гормона.

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