Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press17510.17650/1726-9776-2013-9-1-50-54PROSTATE CANCERРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫTERTIARY GLEASON GRADE ANDULTRASENSITIVE PROSTATE-SPECIFIC ANTIGEN LEVELS AS PROGNOSTIC FACTOR OF PROSTATE CANCER RECURRENCEТРЕТИЧНЫЙ ПОКАЗАТЕЛЬ ГЛИСОНА И СВЕРХМАЛЫЕ ЗНАЧЕНИЯ ПРОСТАТСПЕЦИФИЧЕСКОГО АНТИГЕНА КАК ФАКТОРЫ ПРОГНОЗА РЕЦИДИВА РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫOgnerubovaI. N.ОгнерубоваИ. Н.
Russian Federation

Chair of Oncology

Кафедра онкологии

ognerubova-irina@mail.ruRussian Medical Academy for Postgraduate Traning, MoscowГБОУ ДПО РМАПО Минздрава России, Москва300320139150543007201430072014https://oncourology.abvpress.ru/oncur/article/view/175

In the literature devoted to studying of prognostic factors of biochemical recurrence, the important place is taken away to discussion of ultra-sensitive PSA assays. Some researches have shown that the main value of ultrasensitive prostate-specific antigen (USPSA) level can be identification the patients of high risk group for progression and, as consequence, early revealing of disease recurrence. Subject of special studying is presence and definition of a tertiary Gleason grade (TGG) pattern in radical prostatectomy specimens. In the literature appears more and more the data that the TGG is associated with adverse pathology characteristics and a higher risk of biochemical recurrence.

В литературе, посвященной изучению факторов прогноза биохимического рецидива, значительное место отводится обсуждению ультрачувствительных методов количественного определения сывороточного простатического специфического антигена (ПСА). Несколько исследований показали, что главной ценностью сверхмалых значений ПСА могут быть выделение пациентов группы высокого риска прогрессирования и, как следствие, раннее выявление рецидива заболевания. Кроме этого, предметом специального изучения является присутствие и определение третичного показателя Глисона в образцах опухоли предстательной железы, полученных после радикальной простатэктомии. В литературе появляется все больше данных о том, что третичный показатель связан с неблагоприятными патоморфологическими характеристиками и более высоким риском биохимического рецидива.

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