Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press170710.17650/1726-9776-2024-20-1-94-102DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак мочевого пузыряPhytosanitary products from agriculture associated with the development of bladder cancer among farm owners and farm workers: a systematic reviewФитосанитарные продукты, ассоциированные с риском развития рака мочевого пузыря у работников сельскохозяйственных предприятий: систематический обзорhttps://orcid.org/0000-0002-0368-5899BelcaidN.
Morocco

Noureddine Belcaid.

Fez

Fez

drbelcaidnoureddine@gmail.comDassarI.
Morocco
AbdellaouiA.AbdellaouiА.
Morocco

Abdelfettah Abdellaoui.

Fez

Fez

abdellaouia@yahoo.frTalebM.
Morocco

Fez

Engineering, Electrochemistry, Modeling and Environment LaboratoryFaculty of Sciences Dhar El MahrazSidi Mohamed Ben Abdellah UniversityMinistry of Agriculture, Maritime Fisheries, Rural Development and Water and Forests18052024201941021907202309042024https://oncourology.abvpress.ru/oncur/article/view/1707

Context. Increased bladder cancer prevalence among farm owners and farm workers has been linked to high use of phytosanitary agents in agricultural activities. These results suggested that exposure to phytosanitary products and the risk of bladder cancer may be related.

Objective. Examining the connection between phytosanitary products and the risk of bladder cancer was the goal of the current systematic review and meta-analysis.

Methods. Through PubMed, Scopus, Science Direct, and Web of Science, a thorough literature searches of works updated to 2022 was carried out. The estimates of odd ratio (OR) with 95 % confidence intervals for the highest versus the lowest exposure to pesticide were compiled using fixed- or random-effect models. A prevalence meta-analysis was performed using Cochrane Revman Software.

Results. According to the pooled OR estimates, exposure to phytosanitary conditions was linked to a higher risk of bladder cancer (OR 1.59; 95 % confidence interval 0.51–5.02). Results in the cohort and case–control groups both showed a connection.

Conclusion. According to the majority of studies, exposure to phytosanitary agents and the risk of bladder cancer are directly correlated. According to certain research, smoking may increase the risk of bladder cancer.

Введение. В последние годы наблюдается рост выявляемости рака мочевого пузыря у работников сельскохозяйственных предприятий, отмеченный также с широким использованием фитосанитарных продуктов в агрокультурной деятельности. Предположительно, существует связь между воздействием фитосанитарных продуктов и риском развития рака мочевого пузыря.

Цель – провести систематический обзор литературы и метаанализ в целях изучения взаимосвязи между фитосанитарными продуктами и риском развития рака мочевого пузыря.

Методы. Проведен поиск статей, опубликованных до 2022 г. включительно, в базах данных PubMed, Scopus, Science Direct и Web of Science. Оценку отношения шансов (ОШ) с 95 % доверительными интервалами для самого высокого и низкого уровней контакта с пестицидами проводили с использованием моделей с фиксированными и случайными эффектами. Метаанализ частоты встречаемости выполнен с помощью программного обеспечения Cochrane Revman.

Результаты. Согласно объединенным оценкам ОШ, контакт с фитосанитарными продуктами был связан с повышенным риском рака мочевого пузыря (ОШ 1,59; 95 % ДИ 0,51–5,02). Результаты в когортных группах и группах «случай–контроль» показали наличие ассоциации.

Заключение. Согласно данным большинства исследований, взаимодействие с фитосанитарными агентами напрямую коррелирует с повышенным риском развития рака мочевого пузыря. Результаты некоторых исследований показывают, что курение может повышать этот риск.

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