Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press16610.17650/1726-9776-2012-8-1-88-93DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫPRIMARY TESTICULAR NON-HODGKIN’S LYMPHOMASПЕРВИЧНЫЕ НЕХОДЖКИНСКИЕ ЛИМФОМЫ ЯИЧКАSotnikovaO. P.СотниковаО. П.
Russian Federation
olga100va@yandex.ruSorokinE. N.СорокинЕ. Н.
Russian Federation
olga100va@yandex.ruPoddubnayaI. V.ПоддубнаяИ. В.
Russian Federation
olga100va@yandex.ruRussian Medical Academy of Postgraduate EducationРМАПОN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБУ РОНЦ им. Н.Н. Блохина РАМН, Москва300320128188932907201429072014https://oncourology.abvpress.ru/oncur/article/view/166

Primary testis lymphoma is a rare disease, that accounts for 7 % of all testis neoplasms, 1−2 % of all extranodal lymphomas. In our investigation 62 patients with primary lymphoma of testis were observed. 34 patients (55 %) receved polychemotherapy by antracyclins ± rituximab. 16 patients (25,6 %) were treated by radiochemotherapy. Early appearing recurrence was in 20 cases (57 %) with dissemination in 8 cases. Late recurrence — in 15 (43 %) with dissemination in 5 cases.

Неходжкинские лимфомы (НХЛ) яичка составляют не более 7 % всех злокачественных опухолей яичка и 1−2 % всех экстранодальных НХЛ. Мы описали 62 случая лимфомы яичка. Химиотерапию (ХТ) на основе антрациклинсодержащих (CHOP) режимов ± ритуксимаб получили 34 (55 %) больных. Сочетание ХТ и лучевой терапии применяли у 16 (25,6 %) пациентов. Ранний рецидив наблюдался у 20 (57 %) больных, из них генерализованный — в 8 случаях. Поздний рецидив отмечен у 15 (43 %) пациентов, из них диссеминация процесса наблюдалась только у 5 больных.

primary Non-Hodgkin's testis lymphomapolychemotherapyнеходжкинские лимфомыхимиотерапияяичко1. Bacon C.M., Ye H., Diss T.C. et al. Primary follicular lymphoma of the testis and epididymis in adults. Am J Surg Pathol 2007;31:1050–8.Bacon C.M., Ye H., Diss T.C. et al. Primary follicular lymphoma of the testis and epididymis in adults. Am J Surg Pathol 2007;31:1050–8.2. Streubel B., Scheucher B., Valencak J. et al. Molecular cytogenetic evidence of t(14;18) (IGH;BCL2) in a substantial proportion of primary cutaneous follicle center lymphomas Am J Surg Pathol 2006;30:529–36.Streubel B., Scheucher B., Valencak J. et al. Molecular cytogenetic evidence of t(14;18) (IGH;BCL2) in a substantial proportion of primary cutaneous follicle center lymphomas Am J Surg Pathol 2006;30:529–36.3. Henson J.W. Intraocular lymphoma: Lymphoma of the Nervous System. In: J.W. Henson, T.T. Batchelor. Boston, MA: Butterworth-Heinemann, 2004; p.183– 8.Henson J.W. Intraocular lymphoma: Lymphoma of the Nervous System. In: J.W. Henson, T.T. Batchelor. Boston, MA: Butterworth-Heinemann, 2004; p.183– 8.4. Libra M., Gasparotto D., Gloghini A. et al. Hepatitis C virus (HCV) I hepatitis C virus (HCV) infection and lymphoproliferative disorders. Front Biosci 2005;10:2460–71.Libra M., Gasparotto D., Gloghini A. et al. Hepatitis C virus (HCV) I hepatitis C virus (HCV) infection and lymphoproliferative disorders. Front Biosci 2005;10:2460–71.5. Ming-kun C., Ding-zuan Z., Zi-ke Q. et al. Analysis of clinical and pathological feature of testicular diffuse large B cell lymphoma (a report of 21 cases). J Pract Oncol 2009;51:20.Ming-kun C., Ding-zuan Z., Zi-ke Q. et al. Analysis of clinical and pathological feature of testicular diffuse large B cell lymphoma (a report of 21 cases). J Pract Oncol 2009;51:20.6. Quartuccio L., De Re V., Fabris M. et al. Atypical lymphoproliferation progressing into B-cell lymphoma in rheumatoid arthritis treated with different biological agents: clinical course and molecular characterization. Haematologica 2006;91:691–4.Quartuccio L., De Re V., Fabris M. et al. Atypical lymphoproliferation progressing into B-cell lymphoma in rheumatoid arthritis treated with different biological agents: clinical course and molecular characterization. Haematologica 2006;91:691–4.7. Willemze R., Jansen P.M., Cerroni L. et al. Subcutaneus panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneus Lymphoma Group Study of 83 cases. Blood 2008;111(2):838–45.Willemze R., Jansen P.M., Cerroni L. et al. Subcutaneus panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneus Lymphoma Group Study of 83 cases. Blood 2008;111(2):838–45.8. Abrey L.E., Ben-Porat L., Panageas K.S. et al. Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. J Clin Oncol 2006;24:5711–5.Abrey L.E., Ben-Porat L., Panageas K.S. et al. Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. J Clin Oncol 2006;24:5711–5.9. Morales P., Torres J., Perez-Enguix D. et al. Lymphoproliferative disease after lung and heart-lung transplantation: first description in Spain. Translant Proc 2005; 37(9):4059–63.Morales P., Torres J., Perez-Enguix D. et al. Lymphoproliferative disease after lung and heart-lung transplantation: first description in Spain. Translant Proc 2005; 37(9):4059–63.10. Zucca E., Conconi A., Mughal T.I. et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group. Primary testicular DLCL. 2007; p. 20–6.Zucca E., Conconi A., Mughal T.I. et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group. Primary testicular DLCL. 2007; p. 20–6.11. Van Oers M.H., Klasa R., Marcus R. et al. Rituximab maintenance improves clinical outcome of relapse/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase III intergroup trial. Blood 2006;108(10): 3295–301.Van Oers M.H., Klasa R., Marcus R. et al. Rituximab maintenance improves clinical outcome of relapse/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase III intergroup trial. Blood 2006;108(10): 3295–301.12. Stafford S.L., Kozelsky T.F., Garrity J.A. et al. Orbital lymphoma: radiotherapy outcome and complications. Radiother Oncol 2001;59(2):139–44.Stafford S.L., Kozelsky T.F., Garrity J.A. et al. Orbital lymphoma: radiotherapy outcome and complications. Radiother Oncol 2001;59(2):139–44.13. Jay C., Nemunaitis J., Chen P. et al. miRNA profiling for diagnosis and prognosis of human cancer DNA Cell. Biology 2007; 26:293–300.Jay C., Nemunaitis J., Chen P. et al. miRNA profiling for diagnosis and prognosis of human cancer DNA Cell. Biology 2007; 26:293–300.14. Linzhu Z., Shusen W., Yan H. et al. A retrospective clinical analysis of 30 patients with primary testicular non-hodgkin lymphoma. Chinese J Clin Oncol 2007; 11.Linzhu Z., Shusen W., Yan H. et al. A retrospective clinical analysis of 30 patients with primary testicular non-hodgkin lymphoma. Chinese J Clin Oncol 2007; 11.15. Heroid M., Haas A., Srock S. et al. Rituximab added to first-line mitoxantrone, chlorambucil and prednisolone chemotherapy followed by interferon maintenance prolongs survival in patients with advanced follicular lymphoma: East German Study Group Hematology and Oncology Study. J Clin Oncol 2007; 25(15):1986– 92.Heroid M., Haas A., Srock S. et al. Rituximab added to first-line mitoxantrone, chlorambucil and prednisolone chemotherapy followed by interferon maintenance prolongs survival in patients with advanced follicular lymphoma: East German Study Group Hematology and Oncology Study. J Clin Oncol 2007; 25(15):1986– 92.16. Seymour J.F., Solomon B., Wolf M.M. et al. Primary large-cell non-Hodgkin’s lymphoma of the testis: A retrospective analysis of patterns of failure and prognostic factors. Clin Lymphoma 2001;2:109–15.Seymour J.F., Solomon B., Wolf M.M. et al. Primary large-cell non-Hodgkin’s lymphoma of the testis: A retrospective analysis of patterns of failure and prognostic factors. Clin Lymphoma 2001;2:109–15.17. Lawrie C.H. MicroRNAs and haematology: small molecules, big function. Brit J Haematol 2007;137:503–12.Lawrie C.H. MicroRNAs and haematology: small molecules, big function. Brit J Haematol 2007;137:503–12.18. Ковригина А.М., Пробатова Н.А. Лимфома Ходжкина и крупноклеточные лимфомы. М.: МИА, 2007; c. 153–62.Ковригина А.М., Пробатова Н.А. Лимфома Ходжкина и крупноклеточные лимфомы. М.: МИА, 2007; c. 153–62.19. Менделеева Л.П., Савченко В.Г. Трансплантация гемопоэтических клеток в Российской Федерации (Отчет меж регионального Регистра трансплантации гемопоэтических клеток за 1996 — 2006 гг.). Гематол и трансфузиол 2007;52(6):31–5.Менделеева Л.П., Савченко В.Г. Трансплантация гемопоэтических клеток в Российской Федерации (Отчет меж регионального Регистра трансплантации гемопоэтических клеток за 1996 — 2006 гг.). Гематол и трансфузиол 2007;52(6):31–5.20. Lawrie C.H., Soneji S., Marafioti T. et al. Microrna expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. Intl J Cancer 2007; 121:1156 –61.Lawrie C.H., Soneji S., Marafioti T. et al. Microrna expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. Intl J Cancer 2007; 121:1156 –61.21. Signorelli M., Maneo A., Cammarota G. et al. Conservative management in primary genital lymphomas: the role of chemotherapy. Gynecol Oncol 2007;104:416–21.Signorelli M., Maneo A., Cammarota G. et al. Conservative management in primary genital lymphomas: the role of chemotherapy. Gynecol Oncol 2007;104:416–21.22. Никитин Е.А. Патогенез В-клеточных лимфатических опухолей. В кн.: Е.А. Никитин, А.В. Баранова. Клиническая онкогематология (ред. М.А. Волковой). М.: Медицина, 2007; с. 645–79.Никитин Е.А. Патогенез В-клеточных лимфатических опухолей. В кн.: Е.А. Никитин, А.В. Баранова. Клиническая онкогематология (ред. М.А. Волковой). М.: Медицина, 2007; с. 645–79.23. Levy O., Deangelis L.M., Filippa D.A. et al. Bcl-6 predicts improved prognosis in primary central nervous system lymphoma. Cancer 2008;112:151–6.Levy O., Deangelis L.M., Filippa D.A. et al. Bcl-6 predicts improved prognosis in primary central nervous system lymphoma. Cancer 2008;112:151–6.24. Yoshida S., Nakamura N., Sasaki Y. et al. Primary breast diffuse large B cell lymphoma shows a non-germinal center B-cell phenotype. Modern Pathol 2005;18:398–405.Yoshida S., Nakamura N., Sasaki Y. et al. Primary breast diffuse large B cell lymphoma shows a non-germinal center B-cell phenotype. Modern Pathol 2005;18:398–405.25. Franklin J., Lunt M., Bunn D. et al. Incidence of lymphoma in a large primarycare derived cohort of inflammatory polyarthritis. Ann Rheum Dis 2006; 65:617–22.Franklin J., Lunt M., Bunn D. et al. Incidence of lymphoma in a large primarycare derived cohort of inflammatory polyarthritis. Ann Rheum Dis 2006; 65:617–22.26. Fabris M., Quartuccio L., Sacco S. et al. B-Lymphocyte stimulator (BLyS) up-regulation in mixed cryoglobulinaemia syndrome and hepatitis-C virus infection. Rheumatology 2007;46:37–43.Fabris M., Quartuccio L., Sacco S. et al. B-Lymphocyte stimulator (BLyS) up-regulation in mixed cryoglobulinaemia syndrome and hepatitis-C virus infection. Rheumatology 2007;46:37–43.27. Jung Jun H., Seog Kim W., Hyun Yang J. Orbital infiltration as the first site of relapse of primary testicular T-cell lymphoma. Canc Res Treatmt 2007:39(1):40 –43.Jung Jun H., Seog Kim W., Hyun Yang J. Orbital infiltration as the first site of relapse of primary testicular T-cell lymphoma. Canc Res Treatmt 2007:39(1):40 –43.28. Rubenstein J.L., JFridlyand., Shen A. et al. Gene expression and angiotropism in primary CNS lymphoma. Blood 2006;107:3716–23.Rubenstein J.L., JFridlyand., Shen A. et al. Gene expression and angiotropism in primary CNS lymphoma. Blood 2006;107:3716–23.