Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press161810.17650/1726-9776-2023-19-2-94-100CLINICAL CASEКЛИНИЧЕСКИЙ СЛУЧАЙNeuroendocrine prostate cancerНейроэндокринный рак предстательной железыSafinaS. Z.СафинаС. З.
Russian Federation

29 Sibirskiy Trakt St., Kazan 420029, Russia 

Кандидат медицинских наук, заведующая отделением химиотерапии №3

 Россия, 420029 Казань, ул. Сибирский тракт, 29 

1967125@rambler.ruhttps://orcid.org/0000-0001-8570-99212245-6327IsyangulovaA. Z.ИсянгуловаА. З.
Russian Federation

Alina Zulfatovna Isyangulova 

29 Sibirskiy Trakt St., Kazan 420029, Russia 

Алина Зульфатовна Исянгулова - кандидат медицинских наук, врач-онколог

 Россия, 420029 Казань, ул. Сибирский тракт, 29 

a.isyangulova@rambler.ruRepublican Clinical Oncology Dispensary of the Ministry of Health of the Tatarstan Republic named after prof. M.Z. SigalГАУЗ «Республиканский клинический онкологический диспансер Минздрава Республики Татарстан им. проф. М.З. Сигала»14082023192941000909202206062023https://oncourology.abvpress.ru/oncur/article/view/1618

In Russia, prostate cancer is a common disease with fast increasing incidence. In the vast majority of prostate cancer patients receiving hormone therapy, on average 18–36 months after the start of treatment refractoriness to androgen ablation develops. In 15–20 % of patients, signs of neuroendocrine differentiation may develop.Neuroendocrine prostate cancer is an aggressive variant of castration-resistant prostate cancer with poor prognosis and low survival.Due to the rarity of these types of tumors, specific diagnostic and treatment algorithms have not been developed. As a rule, they are similar to the methods for other malignant forms of prostate cancer and neuroendocrine tumors.

Рак предстательной железы в России является распространенной патологией с высокими показателями темпов роста заболеваемости. У абсолютного большинства больных раком предстательной железы, получающих гормональную терапию, в среднем через 18–36 мес после начала лечения развивается рефрактерность к андрогенной аблации. У 15–20 % пациентов могут развиться признаки нейроэндокринной дифференцировки.Нейроэндокринный рак предстательной железы – агрессивный вариант кастрационно-резистентного рака предстательной железы с плохим прогнозом и низкой выживаемостью.Ввиду редкости этих видов опухолей специфические алгоритмы диагностики и лечения не разработаны. Как правило, они аналогичны методам других злокачественных форм рака предстательной железы и нейроэндокринных опухолей.

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