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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1525</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2022-18-3-128-134</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL NOTES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The probability of developing a tumor in the small intestine neocyst</article-title><trans-title-group xml:lang="ru"><trans-title>Вероятность развития опухоли в тонкокишечном неоцисте</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5071-0604</contrib-id><name-alternatives><name xml:lang="en"><surname>Kеln</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Кельн</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Artem Aleksandrovich Kеln</bold></p><p><italic>54 Odesskaya St., Tyumen 625023;32 Barnaul’skaya St., Tyumen 625000;8/1 Yuriya Semovskykh St., Tyumen 625000</italic></p></bio><bio xml:lang="ru"><p><bold>Артем Александрович Кельн</bold></p><p><italic>625023 Тюмень, ул. Одесская, 54;625000 Тюмень, ул. Барнаульская, 32;</italic><italic>625000 Тюмень, ул. Юрия Семовских, 8/1</italic></p></bio><email>artyom-keln@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6079-0727</contrib-id><name-alternatives><name xml:lang="en"><surname>Petrosyan</surname><given-names>G. S.</given-names></name><name xml:lang="ru"><surname>Петросян</surname><given-names>Г. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>32 Barnaul’skaya St., Tyumen 625000;8/1 Yuriya Semovskykh St., Tyumen 625000</italic></p></bio><bio xml:lang="ru"><p><italic>625000 Тюмень, ул. Барнаульская, 32;625000 Тюмень, ул. Юрия Семовских, 8/1</italic></p></bio><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0818-8621</contrib-id><name-alternatives><name xml:lang="en"><surname>Kupchin</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Купчин</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>32 Barnaul’skaya St., Tyumen 625000;8/1 Yuriya Semovskykh St., Tyumen 625000</italic></p></bio><bio xml:lang="ru"><p><italic>625000 Тюмень, ул. Барнаульская, 32;625000 Тюмень, ул. Юрия Семовских, 8/1</italic></p></bio><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1671-1195</contrib-id><name-alternatives><name xml:lang="en"><surname>Lykov</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Лыков</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>32 Barnaul’skaya St., Tyumen 625000;8/1 Yuriya Semovskykh St., Tyumen 625000</italic></p></bio><bio xml:lang="ru"><p><italic>625000 Тюмень, ул. Барнаульская, 32;625000 Тюмень, ул. Юрия Семовских, 8/1</italic></p></bio><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4644-9861</contrib-id><name-alternatives><name xml:lang="en"><surname>Lebedev</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Лебедев</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>8/1 Yuriya Semovskykh St., Tyumen 625000</italic></p></bio><bio xml:lang="ru"><p><italic>625000 Тюмень, ул. Юрия Семовских, 8/1</italic></p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Volynkina</surname><given-names>L. V.</given-names></name><name xml:lang="ru"><surname>Волынкина</surname><given-names>Л. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>32 Barnaul’skaya St., Tyumen 625000</italic></p></bio><bio xml:lang="ru"><p><italic>625000 Тюмень, ул. Барнаульская, 32</italic></p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tyumen State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Multispecialty Clinical Medical Center “Medical City”</institution></aff><aff><institution xml:lang="ru">ГАУЗ ТО «Многопрофильный клинический медицинский центр «Медицинский город»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Regional Urological Center, “Neftyannik”</institution></aff><aff><institution xml:lang="ru">Областной урологический центр АО «Медико-санитарная часть «Нефтяник»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-10" publication-format="electronic"><day>10</day><month>12</month><year>2022</year></pub-date><volume>18</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>128</fpage><lpage>134</lpage><history><date date-type="received" iso-8601-date="2021-11-28"><day>28</day><month>11</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2022-03-03"><day>03</day><month>03</month><year>2022</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/1525">https://oncourology.abvpress.ru/oncur/article/view/1525</self-uri><abstract xml:lang="en"><p>In clinical practice and scientific literature, there is very little data on the occurrence of tumors in the urinary intestinal reservoirs in patients after radical cystectomy with cystoplasty. A characteristic feature of such tumors is a long latent period before the formation of a relapse from 4 to 32 years.</p><p>The article describes a clinical case of a 1951 patient with a tumor of a small intestinal neocyst. From the patient’s history, there is a long-term hematuria (for 2 years) after radical cystectomy with ileocystoplasty. The intensity of hematuria increased to the formation of profuse with the development of severe anemia. During the examination according to magnetic resonance imaging, computed tomography, ultrasound and invasive diagnostic examinations, no tumor was detected. The patient underwent a diagnostic laparotomy, a tumor was found in the area of ureteral-reservoir anastomosis of the small intestine neocyst. Resection of the small intestine reservoir and ureteral transplantation was performed. The morphological picture of the removed tumor is urothelial cancer of moderate differentiation.</p><p>Secondary tumors of the small intestinal urinary reservoirs are rare and have the structure of adenocarcinoma. The mechanisms of their occurrence have not been fully studied at the moment. Dynamic monitoring of patients after radical cystectomy and ileocystoplasty should be carried out in a specialized center.</p></abstract><trans-abstract xml:lang="ru"><p>В клинической практике и научной литературе крайне мало данных о случаях появления опухолей в мочевых кишечных резервуарах у пациентов после радикальной цистэктомии с цистопластикой. Характерной особенностью таких опухолей считается длительный латентный период до формирования рецидива – от 4 до 32 лет.</p><p>В статье описан клинический случай опухоли тонкокишечного неоциста. После радикальной цистэктомии с илеоцистопластикой у пациента в течение 2 лет отмечалась длительная гематурия. Интенсивность гематурии нарастала до формирования выраженной с развитием тяжелой формы анемии. По данным магнитно-резонансной томографии, компьютерной томографии, ультразвукового исследования и инвазивных диагностических обследований не была выявлена опухоль. Пациенту выполнена диагностическая лапаротомия, при которой обнаружена опухоль в области мочеточниково-резервуарного анастомоза тонкокишечного неоциста. Проведена операция резекции тонкокишечного резервуара и пересадки мочеточников. Морфологическая картина удаленной опухоли – уротелиальный рак умеренной степени дифференцировки.</p><p>Вторичные опухоли тонкокишечных мочевых резервуаров встречаются редко и имеют строение аденокарциномы. Механизмы их возникновения на настоящий момент не изучены в полном объеме. Динамическое наблюдение за пациентами после радикальной цистэктомии и илеоцистопластики должно осуществляться в специализированном центре.</p></trans-abstract><kwd-group xml:lang="en"><kwd>bladder cancer</kwd><kwd>radical cystectomy</kwd><kwd>ileocystoplasty</kwd><kwd>neocyst adenocarcinoma</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак мочевого пузыря</kwd><kwd>радикальная цистэктомия</kwd><kwd>илеоцистопластика</kwd><kwd>аденокарцинома неоциста</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The work was performed without external funding.</funding-statement><funding-statement xml:lang="ru">Работа выполнена без спонсорской поддержки.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Chemakina A.A., Keln A.A. Epidemiology of bladder cancer in Tyumen region in 2008–2018. Akademicheskiy zhurnal Zapadnoy Sibiri = Academic Journal of Western Siberia 2020;16(2):39–43. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Чемакина А.А., Кельн А.А. Эпидемиология рака мочевого пузыря в Тюменской области за период 2008–2018 гг. Академический журнал Западной Сибири 2020;16(2):39–43.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>Jaske G., Algaba F., Fossa S. et al. Recommendations from EAU Working Party on Muscle-Invasive and Metastatic Bladder cancer. Pocket Guidelines European Association of Urology, 2007. Pp. 19–20.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Pejcic T., Hadzi-Djokic J., Acimovic M. et al. Local recurrence of bladder cancer after cystectomy with orthotopic bladder substitution and ileal conduit. Acta Chir Iugosl 2007;54(4):63–7. DOI: 10.2298/aci0704063p</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Berberian G., Goeman L., Allory Y. et al. Adenocarcinoma of ileal neobladder 20 years after cystectomy. Urology 2006;68(6):1343e9–10. DOI: 10.1016/j.urology.2006.09.014</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Moore C.D., Iczkowski K.A., Blue K.M., Algood C.B. Urothelial carcinoma recurrence in ileal orthotopic neobladder: urethrectomy and creation of ileal conduit. Urology 2007;69(1):11–3. DOI: 10.1016/j.urology.2006.10.013</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Hautmann R.E., Volkmer B.G., Schumacher M.C. et al. Long-term results of standard procedures in urology: the ileal neobladder. World J Urol 2006;24(3):305–14. DOI: 10.1007/s00345-006-0105-z</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Oberneder R., Staudte S., Waidelich R. et al. Local recurrence in patients after radical cystectomy and orthotopic ileal neobladder: impact on function. Int Urol Nephrol 2003;35(2):175–9. DOI: 10.1023/b:urol.0000020303.37190.95</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Yossepowitch O., Dalbagni G., Golijanin D. et al. Orthotopic urinary diversion after cystectomy for bladder cancer: implications for cancer control and patterns of disease recurrence. J Urol 2003;169(1):177–81. DOI: 10.1097/01.ju.0000041411.03266.14</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Austen M., Kälble T. Secondary malignancies in different forms of urinary diversion using isolated gut. J Urol 2004;172(3):831–8. DOI: 10.1097/01.ju.0000134890.07434.8e</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Senkul T., Yildirim S., Işeri C. et al. Histopathologic changes in the mucosa of ileal orthotopic neobladder – findings in 24 patients followed up for 5 years. Scand J Urol Nephrol 2003;37(3):35–9. DOI: 10.1080/00365590310008046</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Aragona F., de Caro R., Parenti A. et al. Structural and ultrastructural changes in ileal neobladder mucosa: a 7-year follow-up. Br J Urol 1998;81(1):55–61. DOI: 10.1046/j.1464-410x.1998.00514.x</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Miyake H., Eto H., Takechi Y. et al. Increased urinary 8-hydroxy2’-deoxyguanosine excretion after ileal neobladder replacement. BJU Int 2003;91(7):657–60. DOI: 10.1046/j.1464-410x.2003.04176.x</mixed-citation></ref></ref-list></back></article>
