Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press144210.17650/1726-9776-2021-17-1-108-119DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак мочевого пузыряEfficacy and safety of adjuvant therapy with nivolumab or placebo in high-risk patients with muscle-invasive urothelial carcinoma after radical surgery: review of the first results of the randomized phase III trial CheckMate 274Эффективность и безопасность адъювантной терапии ниволумабом или плацебо у больных мышечно-инвазивным уротелиальным раком группы высокого риска прогрессирования после радикального хирургического лечения: обзор первых результатов рандомизированного исследования III фазы CheckMate 274https://orcid.org/0000-0001-7754-6624VolkovaM. I.ВолковаМ. И.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

Волкова Мария Игоревна.

115478 Москва, Каширское шоссе, 24.

mivolkova@rambler.ruhttps://orcid.org/0000-0003-0389-564XOlshanskayaA. S.ОльшанскаяА. С.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478; 1 Ostrovityanova St., Moscow 117997.

115478 Москва, Каширское шоссе, 24; 117997 Москва, ул. Островитянова, 1.

https://orcid.org/0000-0002-0694-7911KalininS. A.КалининС. А.
Russian Federation

1 Ostrovityanova St., Moscow 117997.

117997 Москва, ул. Островитянова, 1.

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaНациональный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава РоссииN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России060520211711081190505202105052021https://oncourology.abvpress.ru/oncur/article/view/1442

This article analyzes first results of the randomized phase III clinical trial CheckMate 274 that has demonstrated the advantage of adjuvant immunotherapy with nivolumab, a PD-1 inhibitor, over placebo in high-risk patients with muscle-invasive urothelial carcinoma after radical surgery

Данная публикация посвящена обзору первых результатов рандомизированного клинического исследования III фазы CheckMate 274, продемонстрировавших преимущество адъювантной иммунотерапии ингибитором PD-1 ниволумабом по сравнению с плацебо у больных мышечно-инвазивным уротелиальным раком группы высокого риска прогрессирования после радикального хирургического лечения.

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