Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press142310.17650/1726-9776-2022-18-3-107-115REVIEWОБЗОРMolecular-genetic and cytogenetic characteristics of sporadic kidney cancer: literature reviewМолекулярно-генетические и цитогенетические характеристики спорадического рака почки: обзор литературыhttps://orcid.org/0000-0003-2767-7153PopovS. V.ПоповС. В.
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Чугунная, 46

https://orcid.org/0000-0001-9935-0243GuseynovR. G.ГусейновР. Г.
Russian Federation

Ruslan Guseynovich Guseynov

Department of Hospital Surgery, Saint Petersburg State University

46 Chugunnaya St., Saint Petersburg 194044;7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034

Руслан Гусейнович Гусейнов

Кафедра госпитальной хирургии ФГБОУ ВО «Санкт-Петербургский государственный университет»

194044 Санкт-Петербург, ул. Чугунная, 46;199034 Санкт-Петербург, Университетская набережная, 7–9

rusfa@yandex.ruhttps://orcid.org/0000-0002-6664-2861SkryabinO. N.СкрябинО. Н.
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Чугунная, 46

https://orcid.org/0000-0002-7656-4473PerepelitsaV. V.ПерепелицаВ. В.
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Чугунная, 46

https://orcid.org/0000-0003-3062-5119DavydovA. V.ДавыдовА. В.
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Чугунная, 46

https://orcid.org/0000-0001-7580-6197BarkhitdinovR. S.БархитдиновР. С.
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Чугунная, 46

https://orcid.org/0000-0003-3676-6246KatuninA. S.КатунинА. С.
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Чугунная, 46

https://orcid.org/0000-0001-5792-1589MirzabekovM. M.МирзабековМ. М.
Russian Federation

46 Chugunnaya St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Чугунная, 46

St. Luka’s Clinical HospitalСПб ГБУЗ Клиническая больница Святителя ЛукиSaint Petersburg State UniversityФГБОУ ВО «Санкт-Петербургский государственный университет»101220221831071150303202129052022https://oncourology.abvpress.ru/oncur/article/view/1423

To compile this literature review, we studied at least 100 publications devoted to the genetic basis of clear cell, papillary, and chromophobic sporadic kidney cancer pathogenesis. Each of them considered the role of somatic gene and chromosomal mutations in the initiation, promotion, and tumor progression of sporadic renal cell carcinoma, emphasized the importance of determining the mutagenic profile of renal cell carcinoma for the future fate of patients.

Источниками для данного обзора литературы послужили не менее 100 публикаций, посвященных генетическим основам патогенеза светлоклеточного, папиллярного и хромофобного спорадического рака почки, в которых рассматривалась роль соматических генных и хромосомных мутаций в инициации, промоции и опухолевой прогрессии спорадического почечно-клеточного рака и подчеркивалась значимость определения мутагенного профиля почечно-клеточного рака для прогноза для пациентов.

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