Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press1410.17650/1726-9776-2014-10-1-44-48PROSTATE CANCERРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫTHE PRETREATMENT PROSTATE-SPECIFIC ANTIGEN DOUBLING TIME: CLINICAL AND PROGNOSTIC VALUES IN PATIENTS WITH PROSTATE CANCERИСХОДНОЕ ВРЕМЯ УДВОЕНИЯ ПРОСТАТСПЕЦИФИЧЕСКОГО АНТИГЕНА: КЛИНИЧЕСКОЕ И ПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ У БОЛЬНЫХ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫZharinovG. M.ЖариновГ. М.
Russian Federation
urologbogomolov@gmail.comBogomolovO. A.БогомоловО. А.
Russian Federation
urologbogomolov@gmail.comRussian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian, St. PetersburgФГБУ РНЦРХТ Минздрава России, Санкт-Петербург3003201410144482407201424072014https://oncourology.abvpress.ru/oncur/article/view/14

The purpose of the study – to estimate the clinical and prognostic values of the pretreatment prostate specific antigen (PSA) doubling time (PSADT) in patients with prostate cancer.

Materials and methods. Pretreatment PSADT and follow-up information was compiled on 912 men who were treated with external beam radiation therapy (RT). PSADT   were compared with the clinical tumor category, Gleason score, PSA level at diagnosis, as well as the age and level of education of patients. The pretreatment PSADT also were compared with survival rates of patients.

Results. In the current study the correlation between the PSADT and the degree of tumor progression was shown. PSADT decreased with the increase of clinical tumor stage, Gleason score and PSA level at diagnosis. Moreover, in the study the prognostic value of PSADT was confirmed. The statistically and clinically significant associations between the PSADT and all-cause mortality in the setting of PSA failure following have been described.

 

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