Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press124410.17650/1726-9776-2006-2-1-38-40DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак предстательной железыStrontium-89 Chloride in Combined Treatment of Hormone Resistant Prostatic CancerСтронций-89-хлорид в комплексном лечении гормонорезистентного рака предстательной железыKaprinA. D.КапринА. Д.
Russian Federation

Moscow

Москва

SmirnovYu. N.СмирновЮ. Н.
Russian Federation

Moscow

Москва

GafanovR. A.ГафановР. А.
Russian Federation

Moscow

Москва

KostinA. A.КостинА. А.
Russian Federation

Moscow

Москва

Russian National Center of Roentgenology and RadiologyФГУ РНЦРР300320062138402102202021022020https://oncourology.abvpress.ru/oncur/article/view/1244

Hormone resistant phase of prostatic cancer develops after 16-24 months of hormone therapy of metastatic prostatic cancer. Radiopharmaceutical method of treatment is essential for pain control in multiple metastases in the bones; we mean the use of beta-emission isotope strontium-89 chloride (metastrone). Total systems radiotherapy by strontium-89 chloride was carried out as stage III of multiple modality treatment in 90 patients with metastatic hormone-resistant prostatic cancer (HRPC) within the framework of randomized study. Before radiopharmaceutical therapy 18% patients complained of pronounced pain syndrome, 50% presented with moderate pain syndrome, and pathological fractures were diagnosed in 12% patients. Therapy with strontium-89 chloride led to stabilization of the pain syndrome during therapy in 72.7% and to its progress in 27.3% patients. This therapy was well tolerated in general. It can be used as a stage in combined treatment of HRPC patients.

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