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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">124</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2011-7-2-12-17</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE ROLE OF CHRONIC PROSTATITIS IN THE PATHOGENESIS OF PROSTATE CANCER</article-title><trans-title-group xml:lang="ru"><trans-title>РОЛЬ ХРОНИЧЕСКОГО ПРОСТАТИТА В ПАТОГЕНЕЗЕ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pere</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Переверзев</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="UA">Ukraine</country></address><email>tala70@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kharkiv medical academy of postgraduate education</institution></aff><aff><institution xml:lang="ru">Харьковская медицинская академия последипломного образования, г. Харьков</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2011</year></pub-date><volume>7</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>12</fpage><lpage>17</lpage><history><date date-type="received" iso-8601-date="2014-07-27"><day>27</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-27"><day>27</day><month>07</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/124">https://oncourology.abvpress.ru/oncur/article/view/124</self-uri><abstract xml:lang="en"><p>The review of current insights into the role of the previous inflammation in the prostate gland and the development of prostate cancer are presented. The consecutive changes of cellular structures are characterized by proliferative inflammatory atrophy and prostatic intraepithelial neoplasia.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен обзор современных взглядов на роль предшествующего воспаления в простате в развитии рака предстательной железы. Последовательные изменения клеточных структур характеризуются пролиферативной воспалительной атрофией и простатической интраэпителиальной неоплазией.</p></trans-abstract><kwd-group xml:lang="en"><kwd>prostatitis</kwd><kwd>inflammation</kwd><kwd>prostate cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>простатит</kwd><kwd>воспаление</kwd><kwd>рак предстательной железы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. De Mazzo A.M., Platz E.A., Sutchiffe A. Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007;7:256–69.</mixed-citation><mixed-citation xml:lang="ru">De Mazzo A.M., Platz E.A., Sutchiffe A. Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007;7:256–69.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Wagenlehner F.M., Elkahwaji J.E., Algaba F. et al. The role of inflammation and infection in the pathogenesis of prostate carcinoma. BJU Int 2007;100(4):733–7.</mixed-citation><mixed-citation xml:lang="ru">Wagenlehner F.M., Elkahwaji J.E., Algaba F. et al. The role of inflammation and infection in the pathogenesis of prostate carcinoma. BJU Int 2007;100(4):733–7.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Аляев Ю.Г., Народицкий Б.С., Гудков А.В., Винаров А.З. и др. Возможна ли роль микоплазменной инфекции в патогенезе рака предстательной железы. В сб.: Материалы IV конгресса РООУ. М., 2009; с. 23.</mixed-citation><mixed-citation xml:lang="ru">Аляев Ю.Г., Народицкий Б.С., Гудков А.В., Винаров А.З. и др. Возможна ли роль микоплазменной инфекции в патогенезе рака предстательной железы. В сб.: Материалы IV конгресса РООУ. М., 2009; с. 23.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Roberts R.O., Bergstralh E.J., Bass S.E. et al. Prostatitis as a risk factor for prostate cancer. Epidemiology 2004;15:93–9.</mixed-citation><mixed-citation xml:lang="ru">Roberts R.O., Bergstralh E.J., Bass S.E. et al. Prostatitis as a risk factor for prostate cancer. Epidemiology 2004;15:93–9.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Bastian P.J., Nuhn P., Stadler T.C. et al. Prostatitis und Prostatakarzinom. Urologe 2010;49:636–8.</mixed-citation><mixed-citation xml:lang="ru">Bastian P.J., Nuhn P., Stadler T.C. et al. Prostatitis und Prostatakarzinom. Urologe 2010;49:636–8.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Daniels N.A., Ewing S.K., Zmuda J.M. Correlates and prevalence of prostatitis in a large community-based cohort of older men. Urology 2005; 66(5):964–70.</mixed-citation><mixed-citation xml:lang="ru">Daniels N.A., Ewing S.K., Zmuda J.M. Correlates and prevalence of prostatitis in a large community-based cohort of older men. Urology 2005; 66(5):964–70.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Dennis L.K., Lynch C.F., Torner JC. Epidemiologic association between prostatitis and prostate cancer. Urology 2002;60(1):78–83.</mixed-citation><mixed-citation xml:lang="ru">Dennis L.K., Lynch C.F., Torner JC. Epidemiologic association between prostatitis and prostate cancer. Urology 2002;60(1):78–83.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. MacLennan G.T., Eisenberg R., Fleshman R.L. The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study. J Urol 2006;176(3):1012–6.</mixed-citation><mixed-citation xml:lang="ru">MacLennan G.T., Eisenberg R., Fleshman R.L. The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study. J Urol 2006;176(3):1012–6.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Vinarov A.Z., Pshikhachev A.M., Varshavskij V.A., Stoilov S.V. Clinicallchronic prostatitis, and what is morphologically? 25 EAU Congress, 2010, abstr.368.</mixed-citation><mixed-citation xml:lang="ru">Vinarov A.Z., Pshikhachev A.M., Varshavskij V.A., Stoilov S.V. Clinicallchronic prostatitis, and what is morphologically? 25 EAU Congress, 2010, abstr.368.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Wittschieber D., Schenkenberg S., Dietel M., Erbersdobler A. Die Bedeutung der chronischer Prostatitis fur die Pathogenese des Prostatakarzinoms. Urologe A 2010;49(8):947–51.</mixed-citation><mixed-citation xml:lang="ru">Wittschieber D., Schenkenberg S., Dietel M., Erbersdobler A. Die Bedeutung der chronischer Prostatitis fur die Pathogenese des Prostatakarzinoms. Urologe A 2010;49(8):947–51.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Maitland N.J., Collins A.T. Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection? J Cell Biochem 2008;105(4):931–9.</mixed-citation><mixed-citation xml:lang="ru">Maitland N.J., Collins A.T. Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection? J Cell Biochem 2008;105(4):931–9.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Vasto S., Carruba G., Candore G. et al. Inflammation and prostate cancer. Future Oncol 2008;4(5):637–45.</mixed-citation><mixed-citation xml:lang="ru">Vasto S., Carruba G., Candore G. et al. Inflammation and prostate cancer. Future Oncol 2008;4(5):637–45.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Klein E.A., Silverman R. Inflammation, infection, and prostate cancer. Curr Opin Urol 2008;18(3):315–9.</mixed-citation><mixed-citation xml:lang="ru">Klein E.A., Silverman R. Inflammation, infection, and prostate cancer. Curr Opin Urol 2008;18(3):315–9.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Palapattu G.S., Sutcliffe S., Bastian P.J. et al. Prostate carcinogenesis and inflammation: emerging insights. Cancerogenesis 2004;26:1170–81.</mixed-citation><mixed-citation xml:lang="ru">Palapattu G.S., Sutcliffe S., Bastian P.J. et al. Prostate carcinogenesis and inflammation: emerging insights. Cancerogenesis 2004;26:1170–81.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. De Marzo A.M., Marchi V.L., Epstein J.I., Nelson W.G. Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol 1999;155(6):1985–92.</mixed-citation><mixed-citation xml:lang="ru">De Marzo A.M., Marchi V.L., Epstein J.I., Nelson W.G. Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol 1999;155(6):1985–92.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Taylor M.L., Mainous A.G., Wells B.J. Prostate cancer and sexually transmitted diseases: a meta-analysis. Fam Med 2005; 7(7):506–12.</mixed-citation><mixed-citation xml:lang="ru">Taylor M.L., Mainous A.G., Wells B.J. Prostate cancer and sexually transmitted diseases: a meta-analysis. Fam Med 2005; 7(7):506–12.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Naber K., Lobel B., Weidner W. Further insights into endocrine disease the enigma of prostatitis. The International prostate health Council. Sant Malo, France, 2004;20–4.</mixed-citation><mixed-citation xml:lang="ru">Naber K., Lobel B., Weidner W. Further insights into endocrine disease the enigma of prostatitis. The International prostate health Council. Sant Malo, France, 2004;20–4.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Singh A., Purohit A., Ghilchik M.W. The regulation of aromatase activity in breast bibroblasts: the role of interleukin and prostaglandin E2. Endocr Relat Cancer 1999;6:139–47.</mixed-citation><mixed-citation xml:lang="ru">Singh A., Purohit A., Ghilchik M.W. The regulation of aromatase activity in breast bibroblasts: the role of interleukin and prostaglandin E2. Endocr Relat Cancer 1999;6:139–47.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Shah R., Mucci N.R., Amin A. et al. Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander? Am J Pathol 2001;158(5):1767–73.</mixed-citation><mixed-citation xml:lang="ru">Shah R., Mucci N.R., Amin A. et al. Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander? Am J Pathol 2001;158(5):1767–73.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Haverkamp J., Charbonneau B., Ratliff T.L. Prostate inflammation and its potential impact on prostate cancer: a current review. J Cell Biochem 2008;103(5):1344–53.</mixed-citation><mixed-citation xml:lang="ru">Haverkamp J., Charbonneau B., Ratliff T.L. Prostate inflammation and its potential impact on prostate cancer: a current review. J Cell Biochem 2008;103(5):1344–53.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Bastian P.J., Yegnasubramanian S., Palapattur G.S. Molecular biomarker in prostate cancer: the role of CpG island hypermethylation. Eur Urol 2004;46:698–708.</mixed-citation><mixed-citation xml:lang="ru">Bastian P.J., Yegnasubramanian S., Palapattur G.S. Molecular biomarker in prostate cancer: the role of CpG island hypermethylation. Eur Urol 2004;46:698–708.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Nakayama M., Bennett C.J., Hicks J.L. et al. Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am J Pathol 2003;163(3):923–33.</mixed-citation><mixed-citation xml:lang="ru">Nakayama M., Bennett C.J., Hicks J.L. et al. Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am J Pathol 2003;163(3):923–33.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Zheng S.L., Augustsson-Bälter K., Chang B. et al. Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the Cаncer Prostate in Sweden Study. Cancer Res 2004; 15;64(8):2918–22.</mixed-citation><mixed-citation xml:lang="ru">Zheng S.L., Augustsson-Bälter K., Chang B. et al. Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the Cаncer Prostate in Sweden Study. Cancer Res 2004; 15;64(8):2918–22.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Bardia A., Platz E.A., Yegnasubramanian S. et al. Anti-inflammatory drugs, antioxidants, and prostate cancer prevention. Curr Opin Pharmacol 2009;9(4):419–26.</mixed-citation><mixed-citation xml:lang="ru">Bardia A., Platz E.A., Yegnasubramanian S. et al. Anti-inflammatory drugs, antioxidants, and prostate cancer prevention. Curr Opin Pharmacol 2009;9(4):419–26.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. De Marzo A.M., Nelson W.G., Meeker A.K., Coffey D.S. Stem cell features of benign and malignant prostate epithelial cells. J Urol 1998;160:2381–92.</mixed-citation><mixed-citation xml:lang="ru">De Marzo A.M., Nelson W.G., Meeker A.K., Coffey D.S. Stem cell features of benign and malignant prostate epithelial cells. J Urol 1998;160:2381–92.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Bostwick D.G., Alexander E.E., Singh R. et al. Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer 2000;89(1):123–34.</mixed-citation><mixed-citation xml:lang="ru">Bostwick D.G., Alexander E.E., Singh R. et al. Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer 2000;89(1):123–34.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Kirby R.S. A randomized, doubleblind crossover study of tamsulosin and controlled-release doxazosin in patients with benign prostatic hyperplasia. BJU Int 2003;91(1):41–4.</mixed-citation><mixed-citation xml:lang="ru">Kirby R.S. A randomized, doubleblind crossover study of tamsulosin and controlled-release doxazosin in patients with benign prostatic hyperplasia. BJU Int 2003;91(1):41–4.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
