Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press121510.17650/1726-9776-2005-1-2-40-45DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫPrimary multiple prostate and bladder cancer in patients undergone radical cystoprostatectomyПервично-множественный рак мочевого пузыря и предстательной железы у больных, перенесших радикальную цистэктомиюAlekseevB. Ya.АлексеевБ. Я.
Russian Federation

Москва

RusakovI. G.РусаковИ. Г.
Russian Federation

Москва

FrankG. A.ФранкГ. А.
Russian Federation

Москва

AndreevaYu. Yu.АндрееваЮ. Ю.
Russian Federation

Москва

NyushkoK. M.НюшкоК. М.
Russian Federation

Москва

МНИОИ им. П.А. Герцена300620051240452002202020022020https://oncourology.abvpress.ru/oncur/article/view/1215

Objective: The morbidity of multiple urological malignances is steadily grown. Incidental prostate cancer in patients with bladder cancer seems to be fairly often. This is one of the reasons of that the question of partial sparing of prostate in patients undergone radical cystoprostatectomy is still discussable. Purpose: The present study is designed to evaluate the incidence of simultaneous prostate and bladder cancer in patients undergoing radical cystoprostatectomy in Moscow Scientific Research Institute of Oncology.

Materials and methods: From 1994 to 2005, 113 men (mean age 59,5 years), with no evidence of prostatic malignancy on preoperative clinical and biochemical assessment, underwent cystoprostatectomy for TCC of the bladder in our institute. The bladder was adequately sampled and the entire prostate sectioned at 5-mm intervals and examined histologically, in order to identify unsuspected prostatic cancer (PCa).

Results: 10 out of 113 patients (8,8%) were found to have PCa. Four (3,5%) had cr. in situ, five (4,4%) had high grade prostatic intraepithelial neoplasia (PIN). All tumors were clinically significant, except cr. in situ and PIN. Almost all tumors (7,9%) were organ confined (pT2a—T2c), except one (0,9%), which was locale advanced (pT3a). Glaeson score was 2—4 in 5 (26,3%) and 5—7 in 5 (26,3%).

Conclusions: Incidental PCa is quite a common finding in cystoprostatectomy specimens of bladder cancer patients. This demands careful and complete excision of the prostate in patients with muscular-invasive bladder cancer.

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1. Inci O., Kaya E., Alagol B., Atakan I.H. et al. Multiple primary malignant neoplasms in urologic patients // Int. Urol. Nephrol. — 2004; 36(1):1—4.Inci O., Kaya E., Alagol B., Atakan I.H. et al. Multiple primary malignant neoplasms in urologic patients // Int. Urol. Nephrol. — 2004; 36(1):1—4.2. Сельчук В.Ю. Первично-множественные злокачественные опухоли (клиника, лечение, закономерности развития). Дисс... докт. мед. наук. — М., 1994.Сельчук В.Ю. Первично-множественные злокачественные опухоли (клиника, лечение, закономерности развития). Дисс... докт. мед. наук. — М., 1994.3. Chun T.Y. Coincidence of bladder and prostate cancer // J. Urol. — 1997; Jan;157(1):65—67.Chun T.Y. Coincidence of bladder and prostate cancer // J. Urol. — 1997; Jan;157(1):65—67.4. Mydlo J.H., Gerstein M. Patients with urologic cancer and other nonurologic malignancies: analysis of a sample and review of the literature. // Urology. — 2001; Dec;58(6):864—869.Mydlo J.H., Gerstein M. Patients with urologic cancer and other nonurologic malignancies: analysis of a sample and review of the literature. // Urology. — 2001; Dec;58(6):864—869.5. Nakata S., Takahashi H., Takezawa Y. et al. Clinical features of multiple primary cancers including prostate cancer. Hinyokika Kiyo. — 2000; Jun;46(6):385—391.Nakata S., Takahashi H., Takezawa Y. et al. Clinical features of multiple primary cancers including prostate cancer. Hinyokika Kiyo. — 2000; Jun;46(6):385—391.6. Ray P., Guinan P., Sharifi R. et al. Prostate cancer and the multiple primary malignant neoplasm syndrome // Prostate. — 1983;4(5):513—522.Ray P., Guinan P., Sharifi R. et al. Prostate cancer and the multiple primary malignant neoplasm syndrome // Prostate. — 1983;4(5):513—522.7. Галлеев Р.Х. Цистэктомия и илеоцистопластика у больных раком мочевого пузыря. Дисс... докт. мед. наук. — Казань., 1993.Галлеев Р.Х. Цистэктомия и илеоцистопластика у больных раком мочевого пузыря. Дисс... докт. мед. наук. — Казань., 1993.8. Ситдыков Э.Н. Замещение мочевого пузыря изолированной кишечной петлей при раке мочевого пузыря. Дисс... докт. мед. наук. — Казань., 1970.Ситдыков Э.Н. Замещение мочевого пузыря изолированной кишечной петлей при раке мочевого пузыря. Дисс... докт. мед. наук. — Казань., 1970.9. Colombo R., Bertini R., Salonia A. et al. Nerve and seminal sparing radical cystectomy with orthotopic urinary diversion for select patients with superficial bladder cancer: an innovative surgical approach // J. Urol. — 2001; Jan;165(1):51—55; discussion 55.Colombo R., Bertini R., Salonia A. et al. Nerve and seminal sparing radical cystectomy with orthotopic urinary diversion for select patients with superficial bladder cancer: an innovative surgical approach // J. Urol. — 2001; Jan;165(1):51—55; discussion 55.10. Nieuwenhuijzen J.A., Meinhardt W., Horenblas S. Clinical outcomes after sexuality preserving cystectomy and neobladder (prostate sparing cystectomy) in 44 patients // J. Urol. — 2005; Apr;173(4):1314—1317.Nieuwenhuijzen J.A., Meinhardt W., Horenblas S. Clinical outcomes after sexuality preserving cystectomy and neobladder (prostate sparing cystectomy) in 44 patients // J. Urol. — 2005; Apr;173(4):1314—1317.11. Revelo M.P., Cookson M.S., Chang S.S. et al. Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible apical sparing surgery // J. Urol. — 2004; Feb;171(2 Pt 1):646—651.Revelo M.P., Cookson M.S., Chang S.S. et al. Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible apical sparing surgery // J. Urol. — 2004; Feb;171(2 Pt 1):646—651.12. Terrone C., Cracco C., Scarpa R.M., Rossetti S.R. Supra-ampullar cystectomy with preservation of sexual function and ileal orthotopic reservoir for bladder tumor: twenty years of experience // Eur. Urol. — 2004; Aug;46(2):264-269; discussion 269—270.Terrone C., Cracco C., Scarpa R.M., Rossetti S.R. Supra-ampullar cystectomy with preservation of sexual function and ileal orthotopic reservoir for bladder tumor: twenty years of experience // Eur. Urol. — 2004; Aug;46(2):264-269; discussion 269—270.13. Vallancien G., Abou E.l., Fettouh H. et al. Cystectomy with prostate sparing for bladder cancer in 100 patients: 10-year experience. // J. Urol. — 2002; Dec;168(6):2413—2417.Vallancien G., Abou E.l., Fettouh H. et al. Cystectomy with prostate sparing for bladder cancer in 100 patients: 10-year experience. // J. Urol. — 2002; Dec;168(6):2413—2417.14. Zhou F.J., Qin Z.K., Han H. et al. Radical cystectomy with sparing partial prostate for invasive bladder cancer // Ai Zheng. — 2003; Oct;22(10):1066—1069.Zhou F.J., Qin Z.K., Han H. et al. Radical cystectomy with sparing partial prostate for invasive bladder cancer // Ai Zheng. — 2003; Oct;22(10):1066—1069.15. Зисман И. Ф. Клинические аспекты первичной множественности злокачественных новообразований. — Кишинев., 1978.Зисман И. Ф. Клинические аспекты первичной множественности злокачественных новообразований. — Кишинев., 1978.16. Переверзев А.С., Петров С.Б. — Опухоли мочевого пузыря. — Дисс... докт. мед. наук. — Харьков., 2002.Переверзев А.С., Петров С.Б. — Опухоли мочевого пузыря. — Дисс... докт. мед. наук. — Харьков., 2002.17. Bittorf B., Kessler H., Merkel S. et al. Multiple primary malignancies: An epidemiological and pedigree analysis of 57 patients with at least three tumours // Eur. J. Surg. Oncol. — 2001; Apr;27(3):302—313.Bittorf B., Kessler H., Merkel S. et al. Multiple primary malignancies: An epidemiological and pedigree analysis of 57 patients with at least three tumours // Eur. J. Surg. Oncol. — 2001; Apr;27(3):302—313.18. Kinoshita Y., Singh A., Rovito P.M. Jr. et al. Double primary cancers of the prostate and bladder: a literature review // Clin. Prostate Cancer. — 2004; Sep;3(2):83—86.Kinoshita Y., Singh A., Rovito P.M. Jr. et al. Double primary cancers of the prostate and bladder: a literature review // Clin. Prostate Cancer. — 2004; Sep;3(2):83—86.19. Wang C.Y., Jones R.F., Debiec-Rychter M. et al. Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a case-comparison study // Anticancer Res. — 2002; Nov-Dec;22(6B):3529—3535.Wang C.Y., Jones R.F., Debiec-Rychter M. et al. Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a case-comparison study // Anticancer Res. — 2002; Nov-Dec;22(6B):3529—3535.20. Abbas F., Biyabani S.R., Pervez S. Incidental prostate cancer: the importance of complete prostatic removal at cystoprostatectomy for bladder cancer // Urol. Int. — 2000;64(1):52—54.Abbas F., Biyabani S.R., Pervez S. Incidental prostate cancer: the importance of complete prostatic removal at cystoprostatectomy for bladder cancer // Urol. Int. — 2000;64(1):52—54.21. Abbas F., Hochberg D., Civantos F., Soloway M. Incidental prostatic adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer // Eur. Urol. — 1996;30(3):322—326.Abbas F., Hochberg D., Civantos F., Soloway M. Incidental prostatic adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer // Eur. Urol. — 1996;30(3):322—326.22. Angulo J.C., Hontoria J., Dehaini A. et al. Secondary neoplasm in patients with bladder carcinoma. A case-control study. // Actas. Urol. Esp. — 1996; Sep;20(8):720—724.Angulo J.C., Hontoria J., Dehaini A. et al. Secondary neoplasm in patients with bladder carcinoma. A case-control study. // Actas. Urol. Esp. — 1996; Sep;20(8):720—724.23. Bonnal J.L., Irani J., Maidenberg M. et al. Management of bladder cancer associated with prostate cancer // Prog. Urol. — 2003; Dec;13(6):1286—1289.Bonnal J.L., Irani J., Maidenberg M. et al. Management of bladder cancer associated with prostate cancer // Prog. Urol. — 2003; Dec;13(6):1286—1289.24. Demandante C.G., Troyer D.A., Miles T.P. Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. // Am. J. Clin. Oncol. — 2003; Feb;26(1):79—83.Demandante C.G., Troyer D.A., Miles T.P. Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. // Am. J. Clin. Oncol. — 2003; Feb;26(1):79—83.25. Konski A., Rubin P., DiSantangnese P.A. et al. Simultaneous presentation of adenocarcinoma of prostate and transitional cell carcinoma of bladder // Urology. — 1991; Mar;37(3):202—206.Konski A., Rubin P., DiSantangnese P.A. et al. Simultaneous presentation of adenocarcinoma of prostate and transitional cell carcinoma of bladder // Urology. — 1991; Mar;37(3):202—206.26. Kotake T., Kiyohara H. Multiple primary cancers (MPC) associated with bladder cancer: an analysis of the clinical and autopsy cases in Japan // Jpn. J. Clin.Oncol. — 1985; Apr;15 Suppl; 1:201—210.Kotake T., Kiyohara H. Multiple primary cancers (MPC) associated with bladder cancer: an analysis of the clinical and autopsy cases in Japan // Jpn. J. Clin.Oncol. — 1985; Apr;15 Suppl; 1:201—210.27. Reese J.H., Freiha F.S., Gelb A.B. et al. Transitional cell carcinoma of the prostate in patients undergoing radical cystoprostatectomy // J. Urol. — 1992; Jan;147(1):92—95.Reese J.H., Freiha F.S., Gelb A.B. et al. Transitional cell carcinoma of the prostate in patients undergoing radical cystoprostatectomy // J. Urol. — 1992; Jan;147(1):92—95.28. Sanchez-Chapado M., Olmedilla G., Cabeza M. et al. Prevalence of prostate cancer and prostatic intraepithelial neoplasia in Caucasian Mediterranean males: an autopsy study // Prostate. — 2003; Feb. 15;54(3):238—247.Sanchez-Chapado M., Olmedilla G., Cabeza M. et al. Prevalence of prostate cancer and prostatic intraepithelial neoplasia in Caucasian Mediterranean males: an autopsy study // Prostate. — 2003; Feb. 15;54(3):238—247.29. Satoh H., Momma T., Saito S., Hirose S. A case of synchronous triple primary carcinomas of the kidney, bladder and prostate. — Hinyokika Kiyo. — 2003; May;49(5):261—264.Satoh H., Momma T., Saito S., Hirose S. A case of synchronous triple primary carcinomas of the kidney, bladder and prostate. — Hinyokika Kiyo. — 2003; May;49(5):261—264.30. Takada T., Honda M., Momohara C. et al. Synchronous triple urogenital cancer (renal cancer, bladder cancer, prostatic cancer): a case report. — Hinyokika Kiyo. — 2002; Apr;48(4):239—242.Takada T., Honda M., Momohara C. et al. Synchronous triple urogenital cancer (renal cancer, bladder cancer, prostatic cancer): a case report. — Hinyokika Kiyo. — 2002; Apr;48(4):239—242.31. Vallejo Herrador J., Sanchez de la Muela P., Diz Rodriguez R. et al. Synchronous primary urologic triple neoplasia. Report of a new case and review of the literature // Actas Urol. Esp. — 2002; Jan;26(1):57—59.Vallejo Herrador J., Sanchez de la Muela P., Diz Rodriguez R. et al. Synchronous primary urologic triple neoplasia. Report of a new case and review of the literature // Actas Urol. Esp. — 2002; Jan;26(1):57—59.32. Ward J.F., Bartsch G., Sebo T.J. et al. Pathologic characterization of prostate cancers with a very low serum prostate specific antigen (0-2 ng/mL) incidental to cystoprostatectomy: is PSA a useful indicator of clinical significance? // Urol. Oncol. — 2004; Jan-Feb;22(1):40—47.Ward J.F., Bartsch G., Sebo T.J. et al. Pathologic characterization of prostate cancers with a very low serum prostate specific antigen (0-2 ng/mL) incidental to cystoprostatectomy: is PSA a useful indicator of clinical significance? // Urol. Oncol. — 2004; Jan-Feb;22(1):40—47.33. Pritchett T.R., Moreno J., Warner N.E., Lieskovsky G. et al. Unsuspected prostatic adenocarcinoma in patients who have undergone radical cystoprostatectomy for transitional cell carcinoma of the bladder // J. Urol. — 1988; Jun;139(6):1214—1216.Pritchett T.R., Moreno J., Warner N.E., Lieskovsky G. et al. Unsuspected prostatic adenocarcinoma in patients who have undergone radical cystoprostatectomy for transitional cell carcinoma of the bladder // J. Urol. — 1988; Jun;139(6):1214—1216.34. Hind A., Ventura L., Leocata P. et al. Histopathological study of 110 cystectomy specimens for bladder cancer by an original mapping method // J. Exp. Clin. Cancer. Res. — 1998; Mar;17(1):59—64.Hind A., Ventura L., Leocata P. et al. Histopathological study of 110 cystectomy specimens for bladder cancer by an original mapping method // J. Exp. Clin. Cancer. Res. — 1998; Mar;17(1):59—64.35. Попова Т.Н. Диагностика первично-множественных синхронных злокачественных новообразований // Российский онкологический журнал. — 2002. — № 5. — С. 11.Попова Т.Н. Диагностика первично-множественных синхронных злокачественных новообразований // Российский онкологический журнал. — 2002. — № 5. — С. 11.36. Ornstein D.K., Rao G.S., Smith D.S. et al. The impact of systematic prostate biopsy on prostate cancer incidence in men with symptomatic benign prostatic hyperplasia undergoing transurethral resection of the prostate // J. Urol. — 1997; Mar;157(3):880—883; discussion 883—884.Ornstein D.K., Rao G.S., Smith D.S. et al. The impact of systematic prostate biopsy on prostate cancer incidence in men with symptomatic benign prostatic hyperplasia undergoing transurethral resection of the prostate // J. Urol. — 1997; Mar;157(3):880—883; discussion 883—884.37. Niesel T., Breul J., Hartung R. Diagnostic value of additional systematic prostate biopsies in patients undergoing transurethral resection of the prostate // Urology. — 1997; Jun;49(6):869—873; discussion 873—874.Niesel T., Breul J., Hartung R. Diagnostic value of additional systematic prostate biopsies in patients undergoing transurethral resection of the prostate // Urology. — 1997; Jun;49(6):869—873; discussion 873—874.38. Tombal B., De Visccher L., Cosyns J.P. et al. Assessing the risk of unsuspected prostate cancer in patients with benign prostatic hypertrophy: a 13-year retrospective study of the incidence and natural history of T1a-T1b prostate cancers // B.J.U. Int. — 1999; Dec;84(9):1015—1020.Tombal B., De Visccher L., Cosyns J.P. et al. Assessing the risk of unsuspected prostate cancer in patients with benign prostatic hypertrophy: a 13-year retrospective study of the incidence and natural history of T1a-T1b prostate cancers // B.J.U. Int. — 1999; Dec;84(9):1015—1020.39. Minardi D., Galosi A.B., Dell’Atti L. et al. Production of serum-free and total prostate-specific antigen due to prostatic intraepithelial neoplasia. // Scand. J. Urol. Nephrol. — 2002;36(5):323—329.Minardi D., Galosi A.B., Dell’Atti L. et al. Production of serum-free and total prostate-specific antigen due to prostatic intraepithelial neoplasia. // Scand. J. Urol. Nephrol. — 2002;36(5):323—329.40. Monda J.M., Barry M.J., Oesterling J.E. Prostate specific antigen cannot distinguish stage T1a (A1) prostate cancer from benign prostatic hyperplasia // J. Urol. — 1994 May;151(5):1291—1295.Monda J.M., Barry M.J., Oesterling J.E. Prostate specific antigen cannot distinguish stage T1a (A1) prostate cancer from benign prostatic hyperplasia // J. Urol. — 1994 May;151(5):1291—1295.41. Bostwick D.G, Cooner W.H., Denis L. et al. The association of benign prostatic hyperplasia and cancer of the prostate // Cancer. — 1992; Jul, 1;70(1 Suppl):291—301.Bostwick D.G, Cooner W.H., Denis L. et al. The association of benign prostatic hyperplasia and cancer of the prostate // Cancer. — 1992; Jul, 1;70(1 Suppl):291—301.42. Moutzouris G., Barbatis C., Plastiras D. et al. Incidence and histological findings of unsuspected prostatic adenocarcinoma in radical cystoprostatectomy for transitional cell carcinoma of the bladder. // Scand. J. Urol. Nephrol. — 1999. Feb;33(1):27—30.Moutzouris G., Barbatis C., Plastiras D. et al. Incidence and histological findings of unsuspected prostatic adenocarcinoma in radical cystoprostatectomy for transitional cell carcinoma of the bladder. // Scand. J. Urol. Nephrol. — 1999. Feb;33(1):27—30.43. Oka H., Kobayashi S., Kobayashi T. et al. Multiple primary cancers limited to the urological field. — Hinyokika Kiyo. — 2001; Jun;47(6):405—409.Oka H., Kobayashi S., Kobayashi T. et al. Multiple primary cancers limited to the urological field. — Hinyokika Kiyo. — 2001; Jun;47(6):405—409.44. Ozdamar A.S., Gultekin E.Y., Gokalp A. Multiple primary tumours of the urogenital system: our cases and a review of the literature // Int. Urol. Nephrol. — 1997;29(5):511—515.Ozdamar A.S., Gultekin E.Y., Gokalp A. Multiple primary tumours of the urogenital system: our cases and a review of the literature // Int. Urol. Nephrol. — 1997;29(5):511—515.45. Nixon R.G., Chang S.S., Lafleur B.J. et al. Carcinoma in situ and tumor multifocality predict the risk of prostatic urethral involvement at radical cystectomy in men with transitional cell carcinoma of the bladder // J. Urol. — 2002; Feb;167(2 Pt 1):502—505.Nixon R.G., Chang S.S., Lafleur B.J. et al. Carcinoma in situ and tumor multifocality predict the risk of prostatic urethral involvement at radical cystectomy in men with transitional cell carcinoma of the bladder // J. Urol. — 2002; Feb;167(2 Pt 1):502—505.46. Barz H., Barz D. The prevalence of single and synchronous multiple tumours in autopsy series and its dependence on age // Arch. Geschwulstforsch. — 1977;47(5):428—436.Barz H., Barz D. The prevalence of single and synchronous multiple tumours in autopsy series and its dependence on age // Arch. Geschwulstforsch. — 1977;47(5):428—436.47. Burke W.J., McLaughlin J.R., Chung H.D. et al. Occurrence of cancer in Alzheimer and elderly control patients: an epidemiologic necropsy study. — Alzheimer Dis Assoc Disord. — 1994. — Spring; 8(1): 22—28.Burke W.J., McLaughlin J.R., Chung H.D. et al. Occurrence of cancer in Alzheimer and elderly control patients: an epidemiologic necropsy study. — Alzheimer Dis Assoc Disord. — 1994. — Spring; 8(1): 22—28.48. Kawaharada M., Satoh Y. Clinical usefulness of the autopsy in elderly patients // Nippon Ronen Igakkai Zasshi. — 1998; Dec; 35(12): 891—897.Kawaharada M., Satoh Y. Clinical usefulness of the autopsy in elderly patients // Nippon Ronen Igakkai Zasshi. — 1998; Dec; 35(12): 891—897.49. Merminod T., Zulian G.B. Multiple malignant tumours in the elderly // Crit. Rev. Oncol. Hematol. — 2002; Sep;43(3):227—230.Merminod T., Zulian G.B. Multiple malignant tumours in the elderly // Crit. Rev. Oncol. Hematol. — 2002; Sep;43(3):227—230.50. Stemmermann G.N., Nomura A.M., Chyou P.H., Yatani R. A prospective comparison of prostate cancer at autopsy and as a clinical event: the Hawaii Japanese experience // Cancer Epidemiol Biomarkers Prev. — 1992; Mar-Apr; 1(3): 189—193.Stemmermann G.N., Nomura A.M., Chyou P.H., Yatani R. A prospective comparison of prostate cancer at autopsy and as a clinical event: the Hawaii Japanese experience // Cancer Epidemiol Biomarkers Prev. — 1992; Mar-Apr; 1(3): 189—193.