Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press118510.17650/1726-9776-2006-2-2-54-58DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак предстательной железыCurrent hormonal therapy for disseminated prostate cancerСовременная гормонотерапия распространенных форм рака предстательной железыRusakovI. G.РусаковИ. Г.
Russian Federation
BystrovA. A.БыстровА. А.
Russian Federation
AmosovF. R.АмосовФ. Р.
Russian Federation
P.A. Herzen Moscow Cancer Research InstituteМНИОИ им. П.А. ГерценаCity Clinical Hospital No. 62, MoscowГКБ № 62, МоскваMoscow City Cancer DispensaryМосковский городской онкологический диспансер300620062254581802202018022020https://oncourology.abvpress.ru/oncur/article/view/1185

Prostate cancer (PC) is one of the most common malignancies in males. Hormonal therapy (HT) is the method of choice in treating disseminated PC. LHRH agonists are used for therapy of disseminated and metastatic PC; a number of studies have shown the advantages of adjuvant and neoadjuvant HT for its locally advanced process over radiotherapy (RT) alone and radical prostatectomy (RPE). Diferelin (tryptorelin) that has been used for over 20 years is one of the most studied LHRH agonists. The efficiency of HT with diferelin is comparable with that of bilateral orchiectomy, the quality of life being much higher in the patients receiving this drug. The efficiency of intermittent diferelin HT is shown to be the same as that of continuous HT, by considerably improving the quality of life. Diferelin may be used for evaluation of the hormonal sensitivity of a tumor and for choice of an efficient treatment policy. Comparison of diferelin with other LHRH agonists has yielded comparable results in the trend of prostate-specific antigen levels and testosterone concentrations to decrease.

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