<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1172</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2006-2-3-54-58</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical value of chromosomal genetic changes in urothelial cells in urinary bladder cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническое значение молекулярно-генетических изменений в клетках уротелия при раке мочевого пузыря</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bashkatov</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Башкатов</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nemtsova</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Немцова</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karyakin</surname><given-names>O. B.</given-names></name><name xml:lang="ru"><surname>Карякин</surname><given-names>О. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГУ МРНЦ РАМН, Обнинск</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">НИИ молекулярной медицины ММА им. И.М. Сеченова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="ru">Медико-генетический научный центр РАМН</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff id="aff4"><institution>ГУ МРНЦ РАМН, Обнинск</institution></aff><pub-date date-type="pub" iso-8601-date="2006-09-30" publication-format="electronic"><day>30</day><month>09</month><year>2006</year></pub-date><volume>2</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>54</fpage><lpage>58</lpage><history><date date-type="received" iso-8601-date="2020-02-18"><day>18</day><month>02</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-02-18"><day>18</day><month>02</month><year>2020</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/1172">https://oncourology.abvpress.ru/oncur/article/view/1172</self-uri><abstract xml:lang="en"><p>.</p></abstract><trans-abstract xml:lang="ru"><p>.</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Давыдов М.И., Аксель Е.М. Злокачественные новообразования в России и странах СНГ в 2003 г. М.; 2005.</mixed-citation><mixed-citation xml:lang="ru">Давыдов М.И., Аксель Е.М. Злокачественные новообразования в России и странах СНГ в 2003 г. М.; 2005.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Millan-Rodrigez F.,Chechile-Toniolo R. Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J Urol 2000; 163:68–7.</mixed-citation><mixed-citation xml:lang="ru">Millan-Rodrigez F.,Chechile-Toniolo R. Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J Urol 2000; 163:68–7.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Vet J.A., Bringuier P.P., Schaafsma H.E. et al. Comparison of P53 protein overexpression with P53 mutation in bladder cancer: clinical and biologic aspects. Lab Invest 1995;73(6):837–43.</mixed-citation><mixed-citation xml:lang="ru">Vet J.A., Bringuier P.P., Schaafsma H.E. et al. Comparison of P53 protein overexpression with P53 mutation in bladder cancer: clinical and biologic aspects. Lab Invest 1995;73(6):837–43.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Лопаткин Н.А., Мартов Б.М. и соавт. Современные подходы в лечении поверхностного рака мочевого пузыря. В кн.: Рак мочевого пузыря. Материалы 4-й Всероссийской научной конференции с участием стран СНГ. М.; 2002. с. 50–1.</mixed-citation><mixed-citation xml:lang="ru">Лопаткин Н.А., Мартов Б.М. и соавт. Современные подходы в лечении поверхностного рака мочевого пузыря. В кн.: Рак мочевого пузыря. Материалы 4-й Всероссийской научной конференции с участием стран СНГ. М.; 2002. с. 50–1.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Allard P., Bernard P., Fradet Y. еt al. The early clinical course of primary Ta and T1 bladder cancer. Europ Urol 1998;8(1):692–8.</mixed-citation><mixed-citation xml:lang="ru">Allard P., Bernard P., Fradet Y. еt al. The early clinical course of primary Ta and T1 bladder cancer. Europ Urol 1998;8(1):692–8.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Fleming F. et. al. Urinary bladder. In: Cancer staging manual. Philadelphia, Lippincot-Raven;1997. p. 241–24.</mixed-citation><mixed-citation xml:lang="ru">Fleming F. et. al. Urinary bladder. In: Cancer staging manual. Philadelphia, Lippincot-Raven;1997. p. 241–24.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Malmstrom P., BuschC., Norlen B.J. Recurrences, progression and survial in bladder cancer. Scand J Urol Nephrol 1987;21(2):185.</mixed-citation><mixed-citation xml:lang="ru">Malmstrom P., BuschC., Norlen B.J. Recurrences, progression and survial in bladder cancer. Scand J Urol Nephrol 1987;21(2):185.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Kurt K. et al. The nature history and prognosis of tread superficial bladder cancer. EORTC GU Group. Prog Clin Biol Res 1992;378:1.</mixed-citation><mixed-citation xml:lang="ru">Kurt K. et al. The nature history and prognosis of tread superficial bladder cancer. EORTC GU Group. Prog Clin Biol Res 1992;378:1.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Holmang S., Hedelin H., Anderstrom C., Johansson S.L. The relationship among multiple recurrences, progression and prognosis of patients with stages Ta and T1 transitional cell cancer of bladder followed for at least 20 years. J Urol 1995;153(16);1823–6; discussion 1826–7.</mixed-citation><mixed-citation xml:lang="ru">Holmang S., Hedelin H., Anderstrom C., Johansson S.L. The relationship among multiple recurrences, progression and prognosis of patients with stages Ta and T1 transitional cell cancer of bladder followed for at least 20 years. J Urol 1995;153(16);1823–6; discussion 1826–7.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Witjes J.A., Kiemeney L.A., Schaafsma H.E., Debruyn F.M. The influence of review pathology on study outcome of a randomized multicentre superficial bladder cancer trial. Members of the Dutch Sought East cooperative Urological Group. Br J Urol 1994; 73(2): 172–6.</mixed-citation><mixed-citation xml:lang="ru">Witjes J.A., Kiemeney L.A., Schaafsma H.E., Debruyn F.M. The influence of review pathology on study outcome of a randomized multicentre superficial bladder cancer trial. Members of the Dutch Sought East cooperative Urological Group. Br J Urol 1994; 73(2): 172–6.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Placer J. et al. Clinical utility of a multiprobe FISH assay in voided urine specimens for detection of bladder cancer and its recurrences, compared with urinary cytology. Eur Urol 2002;42:547–52.</mixed-citation><mixed-citation xml:lang="ru">Placer J. et al. Clinical utility of a multiprobe FISH assay in voided urine specimens for detection of bladder cancer and its recurrences, compared with urinary cytology. Eur Urol 2002;42:547–52.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Vogelstein B., Kinzler K.W. Cancer genes and the pathways they control. Nature Med 2004; 10: 789–99.</mixed-citation><mixed-citation xml:lang="ru">Vogelstein B., Kinzler K.W. Cancer genes and the pathways they control. Nature Med 2004; 10: 789–99.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Spruk C.H. 3 rd., Ohneseit P.F., Gonzalez-Zulueta M. et al. Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res 1994; 54(3):784–8.</mixed-citation><mixed-citation xml:lang="ru">Spruk C.H. 3 rd., Ohneseit P.F., Gonzalez-Zulueta M. et al. Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res 1994; 54(3):784–8.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Dalbagni S., Presti J.C. Jr., Reuter V.E. et al. Molecular genetic alterations of chromosome 17 and p53 nuclear overexpression in human bladder cancer. Diags Mol Pathol 1993; 2(1):4–13.</mixed-citation><mixed-citation xml:lang="ru">Dalbagni S., Presti J.C. Jr., Reuter V.E. et al. Molecular genetic alterations of chromosome 17 and p53 nuclear overexpression in human bladder cancer. Diags Mol Pathol 1993; 2(1):4–13.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. von Knobloch R. et al. Allelic imbalance at chromosomes 5q,8p and 17p as progression markers for bladder cancer. Aktuel Urol 2000, 31: 83–6.</mixed-citation><mixed-citation xml:lang="ru">von Knobloch R. et al. Allelic imbalance at chromosomes 5q,8p and 17p as progression markers for bladder cancer. Aktuel Urol 2000, 31: 83–6.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Vogelstein B., Kinzler K.W. The genetic basis of human cancerl. McGraw-Hill Medical Pablishing Division; 2002. p. 697–702.</mixed-citation><mixed-citation xml:lang="ru">Vogelstein B., Kinzler K.W. The genetic basis of human cancerl. McGraw-Hill Medical Pablishing Division; 2002. p. 697–702.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Cairns P., Polascik T.J., Eby Y. et al. Frequence of homozygous deletions at p16/CDKN2 in primary human tumors. Nat Genet 1995;11(2):210–2.</mixed-citation><mixed-citation xml:lang="ru">Cairns P., Polascik T.J., Eby Y. et al. Frequence of homozygous deletions at p16/CDKN2 in primary human tumors. Nat Genet 1995;11(2):210–2.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Prat E., Bernues M., Caballin M.R. et al. Detection of chromosomal imbalances in papillary bladder tumors by comparative genomic hybridization. Urology 2001; 57(5):986–92.</mixed-citation><mixed-citation xml:lang="ru">Prat E., Bernues M., Caballin M.R. et al. Detection of chromosomal imbalances in papillary bladder tumors by comparative genomic hybridization. Urology 2001; 57(5):986–92.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. van Rhijn B.W. Lurkin I., Radvanyi F. et al. The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate. Cancer Res 2001; 61(14),1265–8.</mixed-citation><mixed-citation xml:lang="ru">van Rhijn B.W. Lurkin I., Radvanyi F. et al. The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate. Cancer Res 2001; 61(14),1265–8.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Billerey C., Chopin D., Aubriot-Lorton M.H. et al. Frequent FGFR3 mutation in papillary non-invasive bladder (pTa) tumors. Am J Pathol 2001;158(6):1955–9.</mixed-citation><mixed-citation xml:lang="ru">Billerey C., Chopin D., Aubriot-Lorton M.H. et al. Frequent FGFR3 mutation in papillary non-invasive bladder (pTa) tumors. Am J Pathol 2001;158(6):1955–9.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Esrig D., Elmajian D., Groshen S. et al. Accumulation of nuclear p53 and tumor progression in bladder cancer. N Engl J Med 1994;331(19):1259–64.</mixed-citation><mixed-citation xml:lang="ru">Esrig D., Elmajian D., Groshen S. et al. Accumulation of nuclear p53 and tumor progression in bladder cancer. N Engl J Med 1994;331(19):1259–64.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Esrig D., Spruck C.H. 3 rd, Nichols P.W. et al. p53 nuclear protein accumulation correlates with mutation in the p53 gene, tumor grade, and stage in bladder cancer. Am J Pathol 1993;143(5):1389–97.</mixed-citation><mixed-citation xml:lang="ru">Esrig D., Spruck C.H. 3 rd, Nichols P.W. et al. p53 nuclear protein accumulation correlates with mutation in the p53 gene, tumor grade, and stage in bladder cancer. Am J Pathol 1993;143(5):1389–97.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Cordon-Cardo C., Dalbagni G., Saez G.T. et al. P53 mutation in human bladder cancer: Genotypic vs phenotypic patterns. Int J Cancer 1994;56(3):347–53.</mixed-citation><mixed-citation xml:lang="ru">Cordon-Cardo C., Dalbagni G., Saez G.T. et al. P53 mutation in human bladder cancer: Genotypic vs phenotypic patterns. Int J Cancer 1994;56(3):347–53.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Sarkis A.S., Dalbagni G., Cordon-Cardo C. et al. Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: A marker for disease progression. J Natl Cancer Inst 1993;85(1): 53–9.</mixed-citation><mixed-citation xml:lang="ru">Sarkis A.S., Dalbagni G., Cordon-Cardo C. et al. Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: A marker for disease progression. J Natl Cancer Inst 1993;85(1): 53–9.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Bakkar A. Wallerand H., Radvanyi F. et al. FGFR3 and TP53 gene mutation two distinct pathways in urothelial cell carcinoma of the bladder. Cancer Res 2003; 63 (23):8108–12.</mixed-citation><mixed-citation xml:lang="ru">Bakkar A. Wallerand H., Radvanyi F. et al. FGFR3 and TP53 gene mutation two distinct pathways in urothelial cell carcinoma of the bladder. Cancer Res 2003; 63 (23):8108–12.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Hartmann A., Schlake G., Zaak D. et al. Occurrence of chromosome 9 and p53 alteration in multifocal displasia and carcinoma in situ of human urinary bladder. Cancer Res 2002;62:809–18.</mixed-citation><mixed-citation xml:lang="ru">Hartmann A., Schlake G., Zaak D. et al. Occurrence of chromosome 9 and p53 alteration in multifocal displasia and carcinoma in situ of human urinary bladder. Cancer Res 2002;62:809–18.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Belinsky S.A., Nikula K.J., Palmisano W.A. et al. Aberrant methylation of p16 (INK4a) is an early event in lung cancer and potential biomarker for early diagnosis. Proc Natl Acad Sci USA 1998,95(20):11891–6.</mixed-citation><mixed-citation xml:lang="ru">Belinsky S.A., Nikula K.J., Palmisano W.A. et al. Aberrant methylation of p16 (INK4a) is an early event in lung cancer and potential biomarker for early diagnosis. Proc Natl Acad Sci USA 1998,95(20):11891–6.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Obermann E.C., Meyer S., Hellge D. et al Fluorescence in situ hybridization detects frequent chromosome 9 deletions and aneuploidy in histologically normal urothelium of bladder cancer patients. Oncol Rep 2004; 11(4): 745–51.</mixed-citation><mixed-citation xml:lang="ru">Obermann E.C., Meyer S., Hellge D. et al Fluorescence in situ hybridization detects frequent chromosome 9 deletions and aneuploidy in histologically normal urothelium of bladder cancer patients. Oncol Rep 2004; 11(4): 745–51.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Perl A.K., Wilgenbus P., Dahl U. et al. A casual role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998;392(6672):190–3.</mixed-citation><mixed-citation xml:lang="ru">Perl A.K., Wilgenbus P., Dahl U. et al. A casual role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998;392(6672):190–3.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Shariat S.F., Matsumoto K., Casella R. et al. Urinary levels of soluble e-cadherin in the detection of transitional cell carcinoma of the urinary bladder. Eur Urol 2005;48(1):69–76.</mixed-citation><mixed-citation xml:lang="ru">Shariat S.F., Matsumoto K., Casella R. et al. Urinary levels of soluble e-cadherin in the detection of transitional cell carcinoma of the urinary bladder. Eur Urol 2005;48(1):69–76.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Michael W.Y. et al. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin Cancer Res 2002; 8:464–70.</mixed-citation><mixed-citation xml:lang="ru">Michael W.Y. et al. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin Cancer Res 2002; 8:464–70.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Domingues G. et al. p14ARF promoter hypermethylation in plasma DNA as indicator of disease reccurence in bladder cancer patients. Clin Cancer Res 2002; 8:980–5.</mixed-citation><mixed-citation xml:lang="ru">Domingues G. et al. p14ARF promoter hypermethylation in plasma DNA as indicator of disease reccurence in bladder cancer patients. Clin Cancer Res 2002; 8:980–5.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
