Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press116110.17650/1726-9776-2006-2-3-5-11LECTUREЛЕКЦИЯRadiotherapy in patients with bladder cancerЛучевая терапия больных раком мочевого пузыряTkachevS. I.ТкачевС. И.
Russian Federation
FigurinK. M.ФигуринК. М.
Russian Federation
MedvedevS. V.МедведевС. В.
Russian Federation
Moscow N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesГУ РОНЦ им. Н.Н. Блохина РАМН30092006235111802202018022020https://oncourology.abvpress.ru/oncur/article/view/1161

Radiotherapy alone ranks below radical cystectomy in results; but the latter of multimodality organ-preserving therapy are comparable with those of radical cystectomy in patients with the same stage of the disease and of the same age. The development of current radiotherapy technologies, the advent of new effective chemotherapy regimens, and the integration of these methods with organ-preserving surgery offer hope to longer survival and urinary bladder preservation in patients with invasive bladder cancer.

.

1. Давыдов М.И., Аксель Е.М. Злокачественные новообразования в России и странах СНГ в 2003 г. М.; 2005.Давыдов М.И., Аксель Е.М. Злокачественные новообразования в России и странах СНГ в 2003 г. М.; 2005.2. Weef-Messing V., Menon R.S., Hop W.C.J. Cancer of the urinary bladder category T2, T3 (NxM0) treated by interstitial radium implant: Second report. Int J Radiat Oncol Biol Phys 1983; 9: 481–5.Weef-Messing V., Menon R.S., Hop W.C.J. Cancer of the urinary bladder category T2, T3 (NxM0) treated by interstitial radium implant: Second report. Int J Radiat Oncol Biol Phys 1983; 9: 481–5.3. Michaelson D., Zietman A. Invasive bladder cancer: The role of bladder–preserving therapy. ASCO 2003; 457–65.Michaelson D., Zietman A. Invasive bladder cancer: The role of bladder–preserving therapy. ASCO 2003; 457–65.4. Sternberg C.N. The treatment of advanced bladder cancer. Ann Oncol 1995;6:113–26.Sternberg C.N. The treatment of advanced bladder cancer. Ann Oncol 1995;6:113–26.5. Wang C.C. Clinical Radiation Oncology. Indications, Technigues, and Results. Littleton; 1988. p. 273.Wang C.C. Clinical Radiation Oncology. Indications, Technigues, and Results. Littleton; 1988. p. 273.6. Freiha F. Open bladder surgery. In Walsh P., ed Campbells Urologi, 6th ed. Philadelphia: W.B. Saunders; 1992; 2750.Freiha F. Open bladder surgery. In Walsh P., ed Campbells Urologi, 6th ed. Philadelphia: W.B. Saunders; 1992; 2750.7. Herr H. Extent of surgery and pathology evaluation has an impact on bladder out-comes after radical cystectomy. Urology 2003; 61: 105.Herr H. Extent of surgery and pathology evaluation has an impact on bladder out-comes after radical cystectomy. Urology 2003; 61: 105.8. Ярмоненко С.П., Вайнсон А.А. Радиобиология человека и животных. М.; 2004.Ярмоненко С.П., Вайнсон А.А. Радиобиология человека и животных. М.; 2004.9. Stein J.P., Skinner D.G., Montie J.E. Radical cystectomy and pelvic lymphadenectomy in the tritment of infiltrativ bladder cancer. Droller MJ 2001: 267–304.Stein J.P., Skinner D.G., Montie J.E. Radical cystectomy and pelvic lymphadenectomy in the tritment of infiltrativ bladder cancer. Droller MJ 2001: 267–304.10. Mure L. P., Smaaland R., Dahl O. Organ motion, setup variation and tritment margins in radical radiotherapy of urinary bladder cancer. Radiother Oncol 2003; 69: 291–305.Mure L. P., Smaaland R., Dahl O. Organ motion, setup variation and tritment margins in radical radiotherapy of urinary bladder cancer. Radiother Oncol 2003; 69: 291–305.11. Clifford K.S., Perez K.A., Brady L.W. Radiation oncology management decisions. 2-nd edition. Philadelphia USA; 2002.Clifford K.S., Perez K.A., Brady L.W. Radiation oncology management decisions. 2-nd edition. Philadelphia USA; 2002.12. 50 доклад МКРЕ; 1993.50 доклад МКРЕ; 1993.13. Petrovich Z., Stein J.P., Jozsef G., Formenti S.C. Principles and Practice of radiation oncology, 4th ed. Philadelphia, USA; 2004.Petrovich Z., Stein J.P., Jozsef G., Formenti S.C. Principles and Practice of radiation oncology, 4th ed. Philadelphia, USA; 2004.14. Cole D., Durrant R., Roberts J. et al. A pilot study of accelerated fractionation in the radiotherapy of invasive carcinoma of the bladder. Br J Radiol 1992;65(777):792–8.Cole D., Durrant R., Roberts J. et al. A pilot study of accelerated fractionation in the radiotherapy of invasive carcinoma of the bladder. Br J Radiol 1992;65(777):792–8.15. Moonen L., vd Voet H., de Nijs R. et al. Muscle-invasive bladder cancer treated with external beam radiation: influence of total dose, overall treatment time, and treatment interruption on local control. Int J Rad Oncol Biol Phys 1998;42(3):525–30.Moonen L., vd Voet H., de Nijs R. et al. Muscle-invasive bladder cancer treated with external beam radiation: influence of total dose, overall treatment time, and treatment interruption on local control. Int J Rad Oncol Biol Phys 1998;42(3):525–30.16. Edsmyr F., Andersson L., Esposti P.L. et al. Irradiation therapy with multiple small fractions per day in urinary bladder cancer. Radiother Oncol 1985; 4(3), 197–203.Edsmyr F., Andersson L., Esposti P.L. et al. Irradiation therapy with multiple small fractions per day in urinary bladder cancer. Radiother Oncol 1985; 4(3), 197–203.17. Голдобенко Г.В., Матвеев Б.П., Шипилов В.И. Лучевое лечение рака мочевого пузыря при различных режимах фракционирования. Мед радиол 1991; (5): 41–8.Голдобенко Г.В., Матвеев Б.П., Шипилов В.И. Лучевое лечение рака мочевого пузыря при различных режимах фракционирования. Мед радиол 1991; (5): 41–8.18. Emami B., Lyman J., Brown A. et al. Tolerance of normal tissue to therapeutic radiation. Int J Radiat Oncol Biol Phys 1991; 21(1): 109–22.Emami B., Lyman J., Brown A. et al. Tolerance of normal tissue to therapeutic radiation. Int J Radiat Oncol Biol Phys 1991; 21(1): 109–22.19. Milosevic M.F., Gospodarowicz M.K. The Urinal Bladder. Radiation Oncology: Rational, Technigue, and Results, 8-th ed. Eds. By COX J.D. and Ang K.K. Mosby, 2002. p. 575–602.Milosevic M.F., Gospodarowicz M.K. The Urinal Bladder. Radiation Oncology: Rational, Technigue, and Results, 8-th ed. Eds. By COX J.D. and Ang K.K. Mosby, 2002. p. 575–602.20. Zietman A.L., Shipley W.U., Kaufman D.S. et al. Organ-conserving approaches to muscle-invasive bladder cancer: future alternatives to radical cystectomy. Ann Med 2000; 32(1): 34–42.Zietman A.L., Shipley W.U., Kaufman D.S. et al. Organ-conserving approaches to muscle-invasive bladder cancer: future alternatives to radical cystectomy. Ann Med 2000; 32(1): 34–42.21. Miralbell R., Nouet P., Rouzaund M. et al. Radiotherapy of bladder cancer: relevance of bladder volume changes in planning boost treatment. Int J Radiat Oncol Biol Phys 1998; 41: 741–6.Miralbell R., Nouet P., Rouzaund M. et al. Radiotherapy of bladder cancer: relevance of bladder volume changes in planning boost treatment. Int J Radiat Oncol Biol Phys 1998; 41: 741–6.22. Polak A., Zagars G.K., Swanson D.A. Muscle-invasive bladder cancer treat with external beam radiotherapy. Int I Radiat Oncol Biol Phys 1994;30:267–77.Polak A., Zagars G.K., Swanson D.A. Muscle-invasive bladder cancer treat with external beam radiotherapy. Int I Radiat Oncol Biol Phys 1994;30:267–77.23. Матвеев Б.П., Фигурин К.М., Токтомушев А.Т. Результаты органосохраняющей терапии инвазивного рака мочевого пузыря. Урология 2002;(3):3–5.Матвеев Б.П., Фигурин К.М., Токтомушев А.Т. Результаты органосохраняющей терапии инвазивного рака мочевого пузыря. Урология 2002;(3):3–5.24. Токтомушев А.Т. Возможности и перспективы органосохраняющего лечения инвазивного рака мочевого пузыря. Автореф. дис… докт. мед. наук. М.; 2000.Токтомушев А.Т. Возможности и перспективы органосохраняющего лечения инвазивного рака мочевого пузыря. Автореф. дис… докт. мед. наук. М.; 2000.25. Чернышев И.В. Консервативное лечение местнораспространенного рака мочевого пузыря. Автореф. дис… канд. мед. наук. М.; 1998.Чернышев И.В. Консервативное лечение местнораспространенного рака мочевого пузыря. Автореф. дис… канд. мед. наук. М.; 1998.26. Shipley W.U., Kaufman D.S., Zehr E. et al. Selective bladder preservation by combined modality protocol treatment: longterm outcomes of 190 patients with invasive bladder cancer. Urology 2002; 60: 62–8.Shipley W.U., Kaufman D.S., Zehr E. et al. Selective bladder preservation by combined modality protocol treatment: longterm outcomes of 190 patients with invasive bladder cancer. Urology 2002; 60: 62–8.27. Roedel C., Grabenbauer G.G., Kuhn R. et al. Organ preservation in patients with invasive bladder cancer: initial results of an intensified protocol of transurethral surgery and radiation therapy plus concurrent cisplatin and 5-fluorouracil. Int J Rad Oncol Biol Phys 2002; 52(5): 1303–9.Roedel C., Grabenbauer G.G., Kuhn R. et al. Organ preservation in patients with invasive bladder cancer: initial results of an intensified protocol of transurethral surgery and radiation therapy plus concurrent cisplatin and 5-fluorouracil. Int J Rad Oncol Biol Phys 2002; 52(5): 1303–9.28. Попов А.М. Органосохранное лечение инвазивного рака мочевого пузыря. Автореф. дис… канд. мед. наук. Обнинск; 2004.Попов А.М. Органосохранное лечение инвазивного рака мочевого пузыря. Автореф. дис… канд. мед. наук. Обнинск; 2004.