Radiation-induced lower urinary tract events are currently a topical problem despite technological progress and improvement of small pelvic radiotherapy procedures. New preventive treatments for this pathology are constantly developed. The present investigation dealt with ozone therapy used in this nosological entity. It was based on the study of the pathogenesis and morphological changes in the urinary bladder wall during small pelvic radiotherapy in combination with intravesicular ozonized solution. Based on the results of use of this procedure in 40 patients receiving teleradiotherapy applied to the small pelvis, the authors developed an ozone therapy regimen. A pronounced beneficial effect of intravesicular ozone therapy was achieved in a high proportion of patients. The findings were compared with those of the control group of patients receiving no ozone therapy. They were based on a follow-up diagnostic monitoring. The findings give grounds to recommend ozone therapy for the treatment of radiation therapy-induced lower urinary tract events as one of the components of combined therapy for radiation complications.