Hospital-acquired (nosocomial, intrahospital) infections are a principal cause of severe complications and death in cancer diseases in the postoperative period. A current infection-controlling system that notifies all cases of nosocomial infections in the patients of the hospital, including those with urinary tract cancer, has been in existence in Moscow City Cancer Hospital Sixty-Two since 2001. The paper presents the data of the authors' own follow-ups (in 2005—2006), which reflect the incidence of postoperative nosocomial urinary tract infections (PNUTI) in urological cancer patients depending on the site of a tumor, the scope of surgical intervention, the etiological agents of PNUTI, and their susceptibility to antibiotics. By using the results of the study, the authors have developed and proposed algorithms of efficient antibiotic therapy for PNUTI in patients with cancer of the kidney, urinary bladder, and prostate.