Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press11410.17650/1726-9776-2013-9-3-30-36DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почкиUSE OF A COMBINATION OF АVASTIN AND LOW-DOSE INTERFERON- α IN THE FIRST-LINE TREATMENT OF METASTATIC RENAL-CELL CANCERПРИМЕНЕНИЕ КОМБИНАЦИИ АВАСТИНА С НИЗКИМИ ДОЗАМИ ИНТЕРФЕРОНА α В ПЕРВОЙ ЛИНИИ ЛЕЧЕНИЯ МЕТАСТАТИЧЕСКОГО ПОЧЕЧНО-КЛЕТОЧНОГО РАКАKalpinskyA. S.КалпинскийА. С.
Russian Federation

Department of Urology with Course of Urologic Oncology

кафедра урологии с курсом онкоурологии

dr.kalpinskiy@rambler.ruAlekseyevB. Ya.АлексеевБ. Я.
Russian Federation

Department of Urology with Course of Urologic Oncology

кафедра урологии с курсом онкоурологии

dr.kalpinskiy@rambler.ruKaprinA. D.КапринА. Д.
Russian Federation

Department of Urology with Course of Urologic Oncology

кафедра урологии с курсом онкоурологии

dr.kalpinskiy@rambler.ruP.A. Herzen Moscow Oncology Research InstituteМНИОИ им. П.А. ГерценаPeoples’ Friendship University of Russia, MoscowФПК МР РУДН, Москва300920139330362707201427072014https://oncourology.abvpress.ru/oncur/article/view/114

metastatic renal-cell cancertargeted therapyangiogenesis inhibitorsbevacizumabAvastinметастатический почечно-клеточный рактаргетная терапияингибиторы ангиогенезабевацизумабАвастин1. Keane T., Gillatt D., Evans C.P., Tubaro A. Current and future trends in treatment of renal cancer. Eur Urol 2007;Suppl 6:374–84.Keane T., Gillatt D., Evans C.P., Tubaro A. Current and future trends in treatment of renal cancer. Eur Urol 2007;Suppl 6:374–84.2. Cohen H., McGovern F. Renal Cell carcinoma. N Engl J Med 2005;353:3477–90.Cohen H., McGovern F. Renal Cell carcinoma. N Engl J Med 2005;353:3477–90.3. Злокачественные новообразования в России в 2011 году. Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М., 2013.Злокачественные новообразования в России в 2011 году. Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М., 2013.4. Flanigan R.C., Mickisch G., Sylvester R. et al. Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol 2004;171:1071–6.Flanigan R.C., Mickisch G., Sylvester R. et al. Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol 2004;171:1071–6.5. De Mulder P.H.M., Patard J.J., Szczylik C. et al. Current status of targeted therapy in metastatic renal cell carcinoma. Eur Urol 2007;Suppl 6:665–71.De Mulder P.H.M., Patard J.J., Szczylik C. et al. Current status of targeted therapy in metastatic renal cell carcinoma. Eur Urol 2007;Suppl 6:665–71.6. Ljungberg B., Hanbury D.C., Kuczyk M.A. et al. Guidelines on renal cell cancer. European Association of Urology 2013.Ljungberg B., Hanbury D.C., Kuczyk M.A. et al. Guidelines on renal cell cancer. European Association of Urology 2013.7. Patard J.-J. Tyrosine kinase inhibitors in clinical practice: patient selection. Eur Urol Suppl 2008;7:601–9.Patard J.-J. Tyrosine kinase inhibitors in clinical practice: patient selection. Eur Urol Suppl 2008;7:601–9.8. Motzer R.J., Hutson T.E., Tomczak P., et al.Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115–24.Motzer R.J., Hutson T.E., Tomczak P., et al.Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115–24.9. Escudier B., Eisen T., Stadler W. et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356:125–34.Escudier B., Eisen T., Stadler W. et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356:125–34.10. Hudes G., Carducci M., Tomczak P. et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271–81.Hudes G., Carducci M., Tomczak P. et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271–81.11. Motzer R.J., Escudier B., Oudard S. et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449–56.Motzer R.J., Escudier B., Oudard S. et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449–56.12. Escudier B., Pluzanska A., Koralewski P. et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet 2007;370:2103–11.Escudier B., Pluzanska A., Koralewski P. et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet 2007;370:2103–11.13. Avastin prescribing information. Available at http://www.gene.com/gene/products/information/oncology/avastin/insert.jsp. Accessed 7 Dec. 2006.Avastin prescribing information. Available at http://www.gene.com/gene/products/information/oncology/avastin/insert.jsp. Accessed 7 Dec. 2006.14. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: kidney cancer [v.1.2009]. Available at http://www.nccn.org/professionals/physician_ gls/PDF/kidney.pdf.National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: kidney cancer [v.1.2009]. Available at http://www.nccn.org/professionals/physician_ gls/PDF/kidney.pdf.15. Patard J.-J. New Treatment Options for Renal Cell Cancer – Critical Evaluation. Eur. Urol. 2008;Suppl 7:443–6.Patard J.-J. New Treatment Options for Renal Cell Cancer – Critical Evaluation. Eur. Urol. 2008;Suppl 7:443–6.16. Mulders P. Continued progress in treatment of advanced renal cell carcinoma: an update on the role of Sunitinib. Eur Urol 2008;Suppl 7:579584.Mulders P. Continued progress in treatment of advanced renal cell carcinoma: an update on the role of Sunitinib. Eur Urol 2008;Suppl 7:579584.17. Patard J.-J., Rioux-Leclercq N., Fergelot P. Understanding the importance of smart drugs in renal cell carcinoma. Eur Urol 2006;49:633–43.Patard J.-J., Rioux-Leclercq N., Fergelot P. Understanding the importance of smart drugs in renal cell carcinoma. Eur Urol 2006;49:633–43.18. Yang J.C., Haworth L., Sherry R.M. et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427–34.Yang J.C., Haworth L., Sherry R.M. et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427–34.19. Hainsworth J.D., Sosman J.A., Spigel D.R. et al. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J Clin Oncol 2005;23:7889–96.Hainsworth J.D., Sosman J.A., Spigel D.R. et al. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J Clin Oncol 2005;23:7889–96.20. Bukowski R.M., Kabbinavar F.F., Figlin R.A. et al. Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer. J Clin Oncol 2007;25:4536–41.Bukowski R.M., Kabbinavar F.F., Figlin R.A. et al. Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer. J Clin Oncol 2007;25:4536–41.21. Escudier B.J., Ravaud A., Bracarda S. Efficacy and safety of first-line bevacizumab (BEV) plus interferon-α2a (IFN) in subgroups of patients (pts) with metastatic renal cell carcinoma (mRCC). 2008 Genitourinary Cancers Symposium. Abstract № 358.Escudier B.J., Ravaud A., Bracarda S. Efficacy and safety of first-line bevacizumab (BEV) plus interferon-α2a (IFN) in subgroups of patients (pts) with metastatic renal cell carcinoma (mRCC). 2008 Genitourinary Cancers Symposium. Abstract № 358.22. Escudier B.J., Bellmunt J., Negrier S. et al. Final results of the phase III, randomized, double-blind AVOREN trial of first-line bevacizumab (BEV) + interferon-α2a (IFN) in metastatic renal cell carcinoma (mRCC). J Clin Oncol 2009 (suppl);27:15 (abstr 5020).Escudier B.J., Bellmunt J., Negrier S. et al. Final results of the phase III, randomized, double-blind AVOREN trial of first-line bevacizumab (BEV) + interferon-α2a (IFN) in metastatic renal cell carcinoma (mRCC). J Clin Oncol 2009 (suppl);27:15 (abstr 5020).23. Escudier B., Bellmunt J., Négrier S. et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final Analysis of Overall Survival. J Clin Oncol 2010;1;28(13):2144–50.Escudier B., Bellmunt J., Négrier S. et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final Analysis of Overall Survival. J Clin Oncol 2010;1;28(13):2144–50.24. Rini B.I., Halabi S., Rosenberg J.E. et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008;26:5422–8.Rini B.I., Halabi S., Rosenberg J.E. et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008;26:5422–8.25. Rini B.I., Halabi S., Rosenberg J. et al. Phase III trial of bevacizumab plus interferonalpha versus interferon-alpha monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 2010;28:2137–43.Rini B.I., Halabi S., Rosenberg J. et al. Phase III trial of bevacizumab plus interferonalpha versus interferon-alpha monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 2010;28:2137–43.26. Hutson T.E., Figlin R.A., Kuhn J.G., Motzer R.J. Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. The Oncologist 2008;13(10):1084–96.Hutson T.E., Figlin R.A., Kuhn J.G., Motzer R.J. Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. The Oncologist 2008;13(10):1084–96.27. Ravaud A. Treatment-associated adverse event management in the advanced renal cell carcinoma patient treated with targeted therapies. The Oncologist 2011;16 (suppl 2):32–44.Ravaud A. Treatment-associated adverse event management in the advanced renal cell carcinoma patient treated with targeted therapies. The Oncologist 2011;16 (suppl 2):32–44.28. Melichar B., Koralewski P., Ravaud A., Pluzanska A. et al. First-line bevacizumab combined with reduced dose interferon-a2a is active in patients with metastatic renal cell carcinoma. Ann Oncol 2008;19:1470–6.Melichar B., Koralewski P., Ravaud A., Pluzanska A. et al. First-line bevacizumab combined with reduced dose interferon-a2a is active in patients with metastatic renal cell carcinoma. Ann Oncol 2008;19:1470–6.29. Melichar B., Bracarda S., Matveev V. et al. BEVLiN: Prospective study of the safety and efficacy of first-line bevacizumab (BEV) plus low-dose interferon-α2a (IFN) in patients (pts) with metastatic renal cell carcinoma (mRCC). 2011 ASCO Annual Meeting: А 4546.Melichar B., Bracarda S., Matveev V. et al. BEVLiN: Prospective study of the safety and efficacy of first-line bevacizumab (BEV) plus low-dose interferon-α2a (IFN) in patients (pts) with metastatic renal cell carcinoma (mRCC). 2011 ASCO Annual Meeting: А 4546.30. Melichar B., Bracarda S., Matveev V. et al. A multinational phase II trial of bevacizumab with low-dose interferon-α2a as first-line treatment of metastatic renal cell carcinoma: BEVLiN. Ann Oncol 2013;24(9):2396–402.Melichar B., Bracarda S., Matveev V. et al. A multinational phase II trial of bevacizumab with low-dose interferon-α2a as first-line treatment of metastatic renal cell carcinoma: BEVLiN. Ann Oncol 2013;24(9):2396–402.