Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press113310.17650/1726-9776-2007-3-4-21-25DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почкиPrognostic value of expression of thymidine phosphorylase, Bcl-2, and Ki-67 in renal cancer T1-2N0M0Прогностическое значение экспрессии тимидинфосфорилазы, Bcl-2 и Ki-67 при раке почки Т1—2N0M0GutorovS. L.ГуторовС. Л.
Russian Federation

Department of Chemotherapy and Combined Treatments for Malignancies

Moscow

Отделение химиотерапии и комбинированных методов лечения злокачественных опухолей

Москва

StepanovaYe. V.СтепановаЕ. В.
Russian Federation

Department of Chemotherapy and Combined Treatments for Malignancies

Moscow

Отделение химиотерапии и комбинированных методов лечения злокачественных опухолей

Москва

VishnevskayaYa. V.ВишневскаяЯ. В.
Russian Federation

Department of Chemotherapy and Combined Treatments for Malignancies

Moscow

Отделение химиотерапии и комбинированных методов лечения злокачественных опухолей

Москва

ChernoglazovaYe. V.ЧерноглазоваЕ. В.
Russian Federation

Department of Chemotherapy and Combined Treatments for Malignancies

Moscow

Отделение химиотерапии и комбинированных методов лечения злокачественных опухолей

Москва

SokolovaI. N.СоколоваИ. Н.
Russian Federation

Department of Chemotherapy and Combined Treatments for Malignancies

Moscow

Отделение химиотерапии и комбинированных методов лечения злокачественных опухолей

Москва

MatveevV. B.МатвеевВ. Б.
Russian Federation

Department of Chemotherapy and Combined Treatments for Malignancies

Moscow

Отделение химиотерапии и комбинированных методов лечения злокачественных опухолей

Москва

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesРОНЦ им. Н.Н. Блохина РАМН301220073421251602202016022020https://oncourology.abvpress.ru/oncur/article/view/1133

The incidence of the relapse following radical nephrectomy for renal cancer is as high as 20—30%. The traditional predictors (including the histological type of a tumor) are insufficient to predict the likelihood of the relapse. The authors studied the expression of a number of molecular markers including thymidine phosphorylase (TP), Bcl-2, and Ki-67 and their prognostic value in patients with renal cancer (T1—2N0M0). The risk of progression significantly increased in higher grade of the tumor and in cases of TP hyperexpression. The favorable prognostic factors may include the absence of PT expression on the tumor cells.

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