Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press112010.17650/1726-9776-2007-3-3-43-45DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак мочевого пузыряAdjuvant intravesicular chemotherapy for superficial bladder carcinomaАдъювантная внутрипузырная химиотерапия поверхностного рака мочевого пузыряRusakovI. G.РусаковИ. Г.
Russian Federation
BystrovA. A.БыстровА. А.
Russian Federation
TeplovA. A.ТепловА. А.
Russian Federation
PerepechinD. V.ПерепечинД. В.
Russian Federation
P.A. Herzen Moscow Research Oncological InstituteМосковский научно-исследовательский онкологический институт им. П.А. Герцена300920073343451602202016022020https://oncourology.abvpress.ru/oncur/article/view/1120

The paper presents the results of using Vero-Mitomycin in patients with superficial bladder carcinoma (SBC). The study included 23 SBC patients over 18 years of age, with invasion levels of pTa, pT1, and differentiation grades of G1—2, ECOG 0 or 1, who were treated at the Department of Oncourology, P.A. Herzen Moscow Research Oncological Institute. The patients were given 6 intravesicular instillations of Vero-Mitomycin in a single dose of 40 mg. During a follow-up, a recurrence developed in 9 (39.1%) patients, a tumorous process progressed in none patient. There were recurrences at 12—16 months. The acute cystitis syndrome was revealed in 2 patients (after 4 and 6 instillations of the drug). Hematological toxicity was not observed. Thus, Vero-Mitomycin is one of the drugs of choice for the first-line intravesicular chemotherapy in patients with low and moderate risk SBC. Intravesicular chemotherapy with Vero-Mitomycin is an effective and low-toxic preventive method against recurrent SBC.

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