Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press109910.17650/1726-9776-2008-4-2-35-39DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак мочевого пузыряRole of the genetic factors in the formation of malignant neoplasia of urinary bladderРоль генетических факторов в формировании злокачественных новообразований мочевого пузыряPavlovV. N.ПавловВ. Н.
Russian Federation

Ufa city

IzmaylovaS. M.ИзмайловаС. М.
Russian Federation

Ufa city

IzmaylovA. A.ИзмайловА. А.
Russian Federation

Ufa city

ViktorovaT. V.ВиктороваТ. В.
Russian Federation

Ufa city

г. Уфа

Public education institution of the higher professional education Bashkir public medical universityГОУ ВПО Башкирский государственный медицинский университет РосздраваИgenetics and biochemistry institutionИнститут биохимии и генетики УНЦ РАН300620084235391502202015022020https://oncourology.abvpress.ru/oncur/article/view/1099

Malignant neoplasias are one of the most complicated medical and social problems. According to WHO data, about 3% of the all malignant neoplasias are comprised of bladder cancer (BC). According to numerous epidemiological studies, up to 90% of the all malignant neoplasias arise due to hostilities impacts and accumulation of genotoxic substances as well as carcinogens and mutagens. The main genetic factors are considered and their impact on the bladder malignant neoplasias formation is analysed in the article. The given data testify to the important role of the xenobiotics detoxication enzymes, gene methylation state, cytokines activity in the development of the tumor processes and specifically BC.

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