Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press10710.17650/1726-9776-2011-7-1-66-72PROSTATE CANCERРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫROLE OF DEGARELIX (FIRMAGON) IN THE TREATMENT OF DISSEMINATED PROSTATE CANCER: CAN THE QUALITY OF CASTRATION THERAPY BE IMPROVED?РОЛЬ ДЕГАРЕЛИКСА (ФИРМАГОН) В ЛЕЧЕНИИ РАСПРОСТРАНЕННОГО РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ: МОЖНО ЛИ УЛУЧШИТЬ КАЧЕСТВО КАСТРАЦИОННОЙ ТЕРАПИИ?MatveevV. B.МатвеевВ. Б.
Russian Federation
mivolkova@rambler.ruVolkovaM. I.ВолковаМ. И.
Russian Federation
mivolkova@rambler.ruDepartment of Urology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowОтделение урологии РОНЦ им. Н.Н. Блохина РАМН, Москва300320117166722707201427072014https://oncourology.abvpress.ru/oncur/article/view/107

Degarelix (Firmagon) (Ferring Pharmaceuticals) is a new gonadotropin-releasing hormone (GnRH) antagonist permitted and approved for use in the treatment of hormone-dependent prostate cancer. It is recommended to administer the drug subcutaneously in the abdomen in a starting dose of 240 mg, followed by monthly maintenance doses of 80 mg. The Phase III randomized trial demonstrated that degarelix had advantages over the GnRH agonist leuprorelin in the reduction rates for testosterone to castration levels and for prostate-specific antigen (PSA) levels and in the absence of the initial increase and variations of androgen concentrations during treatment. A one-year follow-up showed that the risk of PSA recurrence and death with leuprorelin was significantly higher than that with degarelix. There was a significant reduction in the risk of PSA recurrence in patients switched from leuproprorelin to degarelix. The rates of adverse reactions and treatment discontinuation in the degarelix treatment group do not differ from that in the leuprorelin group. Long-term follow-up studies are required to draw final conclusions.

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