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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1033</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2008-4-1-25-28</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почки</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Sunitinib efficacy in patients with disseminated renal cell carcinoma</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность сунитиниба у больных диссеминированным почечно-клеточным раком</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karyakin</surname><given-names>O. B.</given-names></name><name xml:lang="ru"><surname>Карякин</surname><given-names>О. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Obninsk</p></bio><bio xml:lang="ru"><p>Обнинск</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Obninsk</p></bio><bio xml:lang="ru"><p>Обнинск</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Public institution, medical radiological research center, Russian Academy of Medical Sciences</institution></aff><aff><institution xml:lang="ru">ГУ МРНЦ РАМН</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2008-03-30" publication-format="electronic"><day>30</day><month>03</month><year>2008</year></pub-date><volume>4</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>25</fpage><lpage>28</lpage><history><date date-type="received" iso-8601-date="2020-02-13"><day>13</day><month>02</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-02-13"><day>13</day><month>02</month><year>2020</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/1033">https://oncourology.abvpress.ru/oncur/article/view/1033</self-uri><abstract xml:lang="en"><p>Renal cell carcinoma belongs to a category of chemoresistant tumors. An overall life span of the patients with the disseminated form of disease amounts 10—12 months. Molecular biology development has brought to appearance of the novel kind of systemic treatment — «target» therapy. Use of the given group drugs allows improving the efficacy of the treatment of disseminated renal cancer. According to the guidelines of the European association of urology (EAU), sunitinib is approved as the first line therapy in patients with the favorable and doubtful prognosis.</p></abstract><trans-abstract xml:lang="ru"><p>.</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2005 году (заболеваемость и смертность). М.; 2007.</mixed-citation><mixed-citation xml:lang="ru">Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2005 году (заболеваемость и смертность). М.; 2007.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Novick A.C., Campbell S.C. Renal tumors. In: P.C. Walsh, A.B. Retik, E.D. Vaughan et al. Campbell`s Urology. Philadelphia, WB Saunders; 2002. p. 2672—731.</mixed-citation><mixed-citation xml:lang="ru">Novick A.C., Campbell S.C. Renal tumors. In: P.C. Walsh, A.B. Retik, E.D. Vaughan et al. Campbell`s Urology. Philadelphia, WB Saunders; 2002. p. 2672—731.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Guida M., Colucci G. Immunotherapy for metastatic renal cell carcinoma: is it a therapeutic option yet? Ann Oncol 2007;(Suppl 6):149—52.</mixed-citation><mixed-citation xml:lang="ru">Guida M., Colucci G. Immunotherapy for metastatic renal cell carcinoma: is it a therapeutic option yet? Ann Oncol 2007;(Suppl 6):149—52.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Chow L.Q.M., Eckhardt S.G. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007;25(7):884—96.</mixed-citation><mixed-citation xml:lang="ru">Chow L.Q.M., Eckhardt S.G. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007;25(7):884—96.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Motzer R.J., Mazumdar M., Bacik J. et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999;17:2530—40.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Mazumdar M., Bacik J. et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999;17:2530—40.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. De Mulder P., Patard J.-J., Szczylik C. et al. Current status of targeted therapy in metastatic renal cell carcinoma. Eur Urol 2007;6(10):665—71.</mixed-citation><mixed-citation xml:lang="ru">De Mulder P., Patard J.-J., Szczylik C. et al. Current status of targeted therapy in metastatic renal cell carcinoma. Eur Urol 2007;6(10):665—71.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Motzer R.J., Michaelson M.D., Redman B.G. et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and plateletderived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24(1):16—24.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Michaelson M.D., Redman B.G. et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and plateletderived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24(1):16—24.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Motzer R.J., Rini B.I., Bukowski R.M. et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006;295(21):2516—24.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Rini B.I., Bukowski R.M. et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006;295(21):2516—24.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Rosenberg J.E., Motzer R.J., Michaelson M.D. et al. Sunitinib therapy for patients (pts) with metastatic renal cell carcinoma (mRCC): Updated results of two phase II trials and prognostic factor analysis for survival. ASCO 2007;abstr 5095.</mixed-citation><mixed-citation xml:lang="ru">Rosenberg J.E., Motzer R.J., Michaelson M.D. et al. Sunitinib therapy for patients (pts) with metastatic renal cell carcinoma (mRCC): Updated results of two phase II trials and prognostic factor analysis for survival. ASCO 2007;abstr 5095.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Motzer R.J., Hutson T.E., Tomczak P. et al. Sunitinib versus interferon-alfa in metastatic renal cell carcinoma. N Engl J Med 2007;356(2):115—24.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Hutson T.E., Tomczak P. et al. Sunitinib versus interferon-alfa in metastatic renal cell carcinoma. N Engl J Med 2007;356(2):115—24.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Motzer R.J., Figlin R.A., Hutson T.E. et al. Sunitinib versus interferon-alfa (IFN-α) as first-line treatment of metastatic renal cell carcinoma (mRCC): Updated results and analysis of prognostic factors. ASCO 2007;abstr 5024.</mixed-citation><mixed-citation xml:lang="ru">Motzer R.J., Figlin R.A., Hutson T.E. et al. Sunitinib versus interferon-alfa (IFN-α) as first-line treatment of metastatic renal cell carcinoma (mRCC): Updated results and analysis of prognostic factors. ASCO 2007;abstr 5024.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Gore M.E., Porta C., Oudard S. et al. Sunitinib in metastatic renal cell carcinoma (mRCC): Preliminary assesment of toxicity in an expanded access trial with subpopulation analysis. ASCO 2007;abstr 5010.</mixed-citation><mixed-citation xml:lang="ru">Gore M.E., Porta C., Oudard S. et al. Sunitinib in metastatic renal cell carcinoma (mRCC): Preliminary assesment of toxicity in an expanded access trial with subpopulation analysis. ASCO 2007;abstr 5010.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Remak E., Mullins C.D., Akobundu E. et al. Economic evaluations of sunitinib versus interferon-alfa (IFN ) in first-line metastatic renal cell carcinoma (mRCC). ASCO 2007;abstr 6607.</mixed-citation><mixed-citation xml:lang="ru">Remak E., Mullins C.D., Akobundu E. et al. Economic evaluations of sunitinib versus interferon-alfa (IFN ) in first-line metastatic renal cell carcinoma (mRCC). ASCO 2007;abstr 6607.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Feldman D.R., Kondagunta G.V., Ronnen E.A. et al. Phase I trial of bevacisumab plus sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO 2007;abstr 5099.</mixed-citation><mixed-citation xml:lang="ru">Feldman D.R., Kondagunta G.V., Ronnen E.A. et al. Phase I trial of bevacisumab plus sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO 2007;abstr 5099.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Kondagunta G.V., Hudes G.R., Figlin R. et al. Sunitinib malate (SU) plus interferon (IFN) in first line metastatic renal cell cancer (mRCC): Results of a dose-finding study. ASCO 2007;abstr 5101.</mixed-citation><mixed-citation xml:lang="ru">Kondagunta G.V., Hudes G.R., Figlin R. et al. Sunitinib malate (SU) plus interferon (IFN) in first line metastatic renal cell cancer (mRCC): Results of a dose-finding study. ASCO 2007;abstr 5101.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Patel P.H., Kondagunta G.V., Redman B.G. et al. Phase I/II study of sunitinib malate in combination with gefitinib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO 2007;abstr 5097.</mixed-citation><mixed-citation xml:lang="ru">Patel P.H., Kondagunta G.V., Redman B.G. et al. Phase I/II study of sunitinib malate in combination with gefitinib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO 2007;abstr 5097.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. George D.J., Michaelson M.D., Rosenberg J.E. et al. Phase II trial of sunitinib in bevacisumab-refractory metastatic renal cell carcinoma (mRCC): Updated results and analysis of circulating biomarkers. ASCO 2007;abstr 5035.</mixed-citation><mixed-citation xml:lang="ru">George D.J., Michaelson M.D., Rosenberg J.E. et al. Phase II trial of sunitinib in bevacisumab-refractory metastatic renal cell carcinoma (mRCC): Updated results and analysis of circulating biomarkers. ASCO 2007;abstr 5035.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Sablin M.P., Bouaita L., Balleyguier C. et al. Sequential use of sorafenib and sunitinib in renal cancer: Retrospective analysis in 90 patients. ASCO 2007;abstr 5038.</mixed-citation><mixed-citation xml:lang="ru">Sablin M.P., Bouaita L., Balleyguier C. et al. Sequential use of sorafenib and sunitinib in renal cancer: Retrospective analysis in 90 patients. ASCO 2007;abstr 5038.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Dham A., Dudek A.Z. Sequential therapy with sorafenib and sunitinib in renal cell carcinoma. ASCO 2007;abstr 5106.</mixed-citation><mixed-citation xml:lang="ru">Dham A., Dudek A.Z. Sequential therapy with sorafenib and sunitinib in renal cell carcinoma. ASCO 2007;abstr 5106.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Plantade A., Choueiri T., Escudier B. et al. Treatment outcome for metastatic papillary and chromophobe renal cell carcinoma (RCC) patients treated with tyrosine-kinase inhibitors (TKIs) sunitinib and sorafenib. ASCO 2007;abstr 5037.</mixed-citation><mixed-citation xml:lang="ru">Plantade A., Choueiri T., Escudier B. et al. Treatment outcome for metastatic papillary and chromophobe renal cell carcinoma (RCC) patients treated with tyrosine-kinase inhibitors (TKIs) sunitinib and sorafenib. ASCO 2007;abstr 5037.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Hutson T.E., Figlin R.A. Evolving role of novel targeted agents in renal cell carcinoma. Oncology 2007;21:1175—80.</mixed-citation><mixed-citation xml:lang="ru">Hutson T.E., Figlin R.A. Evolving role of novel targeted agents in renal cell carcinoma. Oncology 2007;21:1175—80.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Escudier B., Koralewski P., Pluzanska A. et al. A randomized, controlled, doubleblind phase III study (AVOREN) of bevacizumab/interferon-2a vs placebo/interferon-2a as first-line therapy in metastatic renal cell carcinoma. J Clin Oncol 2007;25(18S):abstr 3.</mixed-citation><mixed-citation xml:lang="ru">Escudier B., Koralewski P., Pluzanska A. et al. A randomized, controlled, doubleblind phase III study (AVOREN) of bevacizumab/interferon-2a vs placebo/interferon-2a as first-line therapy in metastatic renal cell carcinoma. J Clin Oncol 2007;25(18S):abstr 3.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
