Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press10010.17650/1726-9776-2011-7-1-57-61PROSTATE CANCERРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫEFFICIENCY OF HORMONE THERAPY WITH LEIPRORELIN (LUCRIN DEPOT®) IN PATIENTS WITH PROSTATE CANCERЭФФЕКТИВНОСТЬ ГОРМОНАЛЬНОЙ ТЕРАПИИ ПРЕПАРАТОМ ЛЕЙПРОРЕЛИН (ЛЮКРИН ДЕПО®) У БОЛЬНЫХ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫAlekseevB. Ya.АлексеевБ. Я.
Russian Federation

Кафедра урологии с курсом онкоурологии

byalekseev@mail.ruKaprinA. D.КапринА. Д.
Russian Federation
byalekseev@mail.ruNyushkoK. M.НюшкоК. М.
Russian Federation
byalekseev@mail.ruDepartment of Oncourology, P.A. Herzen Moscow Oncology Research Institute Department of Urology with a Course of Oncourology, Faculty for Postgraduate Training of Medical Workers, Russian Peoples Friendship UniversityОтделение онкоурологии ФГУ МНИОИ им. П.А. Герцена Минздравсоцразвития РФ ФПК МР РУДНDepartment of Urology with a Course of Oncourology, Faculty for Postgraduate Training of Medical Workers, Russian Peoples Friendship University City Clinical Hospital Twenty, MoscowКафедра урологии с курсом онкоурологии ФПК МР РУДН 3ГКБ № 20, МоскваDepartment of Oncourology, P.A. Herzen Moscow Oncology Research InstituteОтделение онкоурологии ФГУ МНИОИ им. П.А. Герцена Минздравсоцразвития РФ300320117157612707201427072014https://oncourology.abvpress.ru/oncur/article/view/100

Prostate cancer (PC) is one of the most common cancers. Hormone therapy (HT) is the basic treatment for metastatic hormone-sensitive PC. HT with luteinizing-hormone-releasing hormone (LHRH) analogues is considered to be an effective method for hormone exposure as monotherapy and in combination with other drugs. Lucrin depot® is a potent and safe LHRH analogue whose efficacy has been proven by a number of clinical trials. This drug may be recommended as monotherapy or in combination with other hormonal agents in patients with PC if there are indications for androgen deprivation.

Рак предстательной железы (РПЖ) — одно из наиболее распространенных онкологических заболеваний. Гормональная терапия (ГТ) является основным методом терапии метастатического гормоночувствительного РПЖ. ГТ аналогами лютеинезирующего гонадотропин-рилизинг-гормона (ЛГРГ) считается эффективным методом гормонального воздействия, как в качестве самостоятельной терапии, так и в комбинации с другими препаратами. Люкрин депо® — действенный и безопасный аналог ЛГРГ, эффективность которого доказана рядом клинических исследований. Данный препарат может быть рекомендован в качестве самостоятельной терапии или в комбинации с другими гормональными препаратами у больных РПЖ при наличии показаний к проведению андрогенной депривации.

prostate cancerhormone therapyluteinizing-hormone-releasing hormone analoguesLucrin depot®рак предстательной железыгормональная терапияаналоги ЛГРГЛюкрин депо®1. Ries L.A.G., Kosary C.L., Hankey B.F. et al. (eds). SEER Cancer Statistics Review 1973–1995 Bethesda, MD: National Cancer Institute, 1998.Ries L.A.G., Kosary C.L., Hankey B.F. et al. (eds). SEER Cancer Statistics Review 1973–1995 Bethesda, MD: National Cancer Institute, 1998.2. Чиссов В.И., Старинский В.В., Петрова Г. В. Злокачественные новообразования в России в 2007 году. М., 2009.Чиссов В.И., Старинский В.В., Петрова Г. В. Злокачественные новообразования в России в 2007 году. М., 2009.3. Матвеев В.Б. Клиническая онкоурология. М., 2003; с. 525–70.Матвеев В.Б. Клиническая онкоурология. М., 2003; с. 525–70.4. Heidenreich A., Varga Z., Von Knobloch R. Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis. J Urol 2003;169(3):1090.Heidenreich A., Varga Z., Von Knobloch R. Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis. J Urol 2003;169(3):1090.5. Partin A.W., Kattan M.W., Subong E.N. et al. Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update. JAMA. 1997;277(18):1445–51.Partin A.W., Kattan M.W., Subong E.N. et al. Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update. JAMA. 1997;277(18):1445–51.6. Huggins C., Hoges C.V. Studies on prostate cancer. The effect of castration. Cancer Res 1941;385–402.Huggins C., Hoges C.V. Studies on prostate cancer. The effect of castration. Cancer Res 1941;385–402.7. Daneshgari F., Crawford E.D. Endocrine herapy of advanced carcinoma of the prostate. Cancer 1993;71:1089–97.Daneshgari F., Crawford E.D. Endocrine herapy of advanced carcinoma of the prostate. Cancer 1993;71:1089–97.8. Bolla M., Collette L., Blank L. et al. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial. Lancet. 2002;360(9327):103–8.Bolla M., Collette L., Blank L. et al. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial. Lancet. 2002;360(9327):103–8.9. Lawton C.A., Winter K., Murray K. et al. Updated results of the phase III Radiation Therapy Oncology Group (RTOG) trial 85-31 evaluating the potential benefit of androgen suppression following standard radiation therapy for unfavorable prognosis carcinoma of the prostate. Int J Radiat Oncol Biol Phys 2001;49(4):937–6.Lawton C.A., Winter K., Murray K. et al. Updated results of the phase III Radiation Therapy Oncology Group (RTOG) trial 85-31 evaluating the potential benefit of androgen suppression following standard radiation therapy for unfavorable prognosis carcinoma of the prostate. Int J Radiat Oncol Biol Phys 2001;49(4):937–6.10. Pilepich M.V., Winter K., John M.J. et al. Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate. Int J Radiat Oncol Biol Phys 200;50(5):1243–52.Pilepich M.V., Winter K., John M.J. et al. Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate. Int J Radiat Oncol Biol Phys 200;50(5):1243–52.11. Pilepich M.V., Winter K., Lawton C.A. et al. Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma – long-term results of phase III RTOG 85-31. Int J Radiat Oncol Biol Phys 2005;61(5):1285–90.Pilepich M.V., Winter K., Lawton C.A. et al. Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma – long-term results of phase III RTOG 85-31. Int J Radiat Oncol Biol Phys 2005;61(5):1285–90.12. Messing E.M., Manola J., Yao J. et al. Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy. Lancet Oncol 2006;7(6):472–9.Messing E.M., Manola J., Yao J. et al. Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy. Lancet Oncol 2006;7(6):472–9.13. Seruga B., Tannock I.F. Intermittent androgen blockade should be regarded as standard therapy in prostate cancer. Nat Clin Pract Oncol 2008;5(10):574–6.Seruga B., Tannock I.F. Intermittent androgen blockade should be regarded as standard therapy in prostate cancer. Nat Clin Pract Oncol 2008;5(10):574–6.14. Labrie F., Belanger A., Dupont A. et al. Science behind total androgen blockade: from gene to combination therapy. Clin Invest Med 1993;16(6):475–92.Labrie F., Belanger A., Dupont A. et al. Science behind total androgen blockade: from gene to combination therapy. Clin Invest Med 1993;16(6):475–92.15. Chrisp P., Sorkin E.M. Leuprorelin:a review of its pharmacology and therapeutic use in prostatic disorders. Drugs Aging 199;1:487–509.Chrisp P., Sorkin E.M. Leuprorelin:a review of its pharmacology and therapeutic use in prostatic disorders. Drugs Aging 199;1:487–509.16. Sharifi R., Ratanwong C., Jung A. et al. Therapeutic effects of leuprorelin microspheres in prostate cancer. Adv Drug Deliv Rev 1997;28:121–36. [PubMed]Sharifi R., Ratanwong C., Jung A. et al. Therapeutic effects of leuprorelin microspheres in prostate cancer. Adv Drug Deliv Rev 1997;28:121–36. [PubMed]17. Togushi H. Formulation study of leuprorelin acetate to improve clinical performance. Clin Ther 1992;14:121–30.Togushi H. Formulation study of leuprorelin acetate to improve clinical performance. Clin Ther 1992;14:121–30.18. Crawford E.D., Sartor O., Chu F. et al. A 12-month clinical study of LA-2585 (45.0 mg): a new 6-month subcutaneous delivery system for leuprolide acetate for the treatment of prostate cancer. J Urol 2006;175:533–6.Crawford E.D., Sartor O., Chu F. et al. A 12-month clinical study of LA-2585 (45.0 mg): a new 6-month subcutaneous delivery system for leuprolide acetate for the treatment of prostate cancer. J Urol 2006;175:533–6.19. Tunn U.W., Wiedey K. Safety and clinical efficacy of a new 6-month depot formulation of leuprorelin acetate in patients with prostate cancer in Europe. Prostate Cancer Prostatic Dis 2009;12(1):83–7.Tunn U.W., Wiedey K. Safety and clinical efficacy of a new 6-month depot formulation of leuprorelin acetate in patients with prostate cancer in Europe. Prostate Cancer Prostatic Dis 2009;12(1):83–7.20. Berges R., Bello U. Effect of a new leuprorelin formulation on testosterone levels in patients with advanced prostate cancer. Curr Med Res Opin 2006;22(4):649–55.Berges R., Bello U. Effect of a new leuprorelin formulation on testosterone levels in patients with advanced prostate cancer. Curr Med Res Opin 2006;22(4):649–55.21. Tunn U.W., Kurek R., Renneberg H. et al. Intermittent complete androgen blockade in PSA relapse after radical prostatectomy and incidental prostate cancer. Eur Urol 1999;35 (Suppl 1):27–31.Tunn U.W., Kurek R., Renneberg H. et al. Intermittent complete androgen blockade in PSA relapse after radical prostatectomy and incidental prostate cancer. Eur Urol 1999;35 (Suppl 1):27–31.22. Gleave M.E., Goldenberg S.L., Chin J.L. et al. Randomized comparative study of 3 versus 8-month neoadjuvant hormonal therapy before radical prostatectomy: biochemical and pathological effects. J Urol 2001 Aug;166(2):500–6.Gleave M.E., Goldenberg S.L., Chin J.L. et al. Randomized comparative study of 3 versus 8-month neoadjuvant hormonal therapy before radical prostatectomy: biochemical and pathological effects. J Urol 2001 Aug;166(2):500–6.23. Soloway M.S., Pareek K., Sharifi R. et al. Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results. J Urol 2002;167(1):112–6.Soloway M.S., Pareek K., Sharifi R. et al. Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results. J Urol 2002;167(1):112–6.24. Montgomery B.S., Borwell J.P., Higgins D.M. Does needle size matters? Patient experience with luteinizing hormone releasing hormone analogue. Prostate Cancer Prostatic Dis 2005;8:66–8.Montgomery B.S., Borwell J.P., Higgins D.M. Does needle size matters? Patient experience with luteinizing hormone releasing hormone analogue. Prostate Cancer Prostatic Dis 2005;8:66–8.25. Heyns C.F., Simonin M.P., Grosgurin P. et al. Comparative efficacy of triptorelin pamoate and leuprolide acetate in men with advanced prostate cancer. BJU Int 2003;92(3):226–31.Heyns C.F., Simonin M.P., Grosgurin P. et al. Comparative efficacy of triptorelin pamoate and leuprolide acetate in men with advanced prostate cancer. BJU Int 2003;92(3):226–31.