Email this article PROGNOSTIC VALUE OF MATRIX METALLOPROTEINASE 9 IN RENAL CELL CARCINOMA
- Authors: Cherdantseva T.M.1,2, Bobrov I.P.1,2, Varlamov S.V.2, Myadelets M.N.1, Klimachev I.V.1, Avdalyan A.M.2, Ganov D.I.1,2, Lazarev A.F.1,2
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Affiliations:
- Altai State Medical University, Ministry of Health of Russia
- Altai Branch of the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
- Issue: Vol 14, No 3 (2018)
- Pages: 17-24
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER
- Published: 30.09.2018
- URL: https://oncourology.abvpress.ru/oncur/article/view/820
- DOI: https://doi.org/10.17650/1726-9776-2018-14-3-17-24
- ID: 820
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Abstract
Objective: to assess matrix metalloproteinase 9 (MMP-9) expression in renal cell carcinoma cells and cells of intratumoral inflammatory infiltrates depending on clinical and morphological characteristics and postoperative survival.
Materials and methods. We evaluated MMP-expression in 108 renal cancer tissue specimens. The intensity of immunohistochemical staining was estimated by measuring integral optical density in cytoplasm.
Results. We found that the integral optical density of MMP-9 immunostaining in tumor cells and cells of intratumoral inflammatory infiltrates correlates with important prognostic factors for renal cancer, including histological type of cancer, TNM stage, tumor size, Fuhrman nuclear grade, metastasis, and 5-year postoperative survival.
Conclusion. Integral optical density of MMP-9 immunostaining is an additional prognostic factor for renal cell carcinoma.
Keywords
About the authors
T. M. Cherdantseva
Altai State Medical University, Ministry of Health of Russia; Altai Branch of the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Author for correspondence.
Email: cherdan.morf@yandex.ru
ORCID iD: 0000-0002-7292-4996
40 Lenina St., Barnaul 656038; 77 Nikitina St., Barnaul 656049. Russian Federation
I. P. Bobrov
Altai State Medical University, Ministry of Health of Russia; Altai Branch of the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Email: Sergei_varlamov@mail.ru
40 Lenina St., Barnaul 656038; 77 Nikitina St., Barnaul 656049. Russian Federation
S. V. Varlamov
Altai Branch of the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Email: Sergei_varlamov@mail.ru
77 Nikitina St., Barnaul 656049. Russian Federation
M. N. Myadelets
Altai State Medical University, Ministry of Health of Russia
Email: Sergei_varlamov@mail.ru
40 Lenina St., Barnaul 656038. Russian Federation
I. V. Klimachev
Altai State Medical University, Ministry of Health of Russia
Email: Sergei_varlamov@mail.ru
40 Lenina St., Barnaul 656038. Russian Federation
A. M. Avdalyan
Altai Branch of the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Email: Sergei_varlamov@mail.ru
77 Nikitina St., Barnaul 656049. Russian Federation
D. I. Ganov
Altai State Medical University, Ministry of Health of Russia; Altai Branch of the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Email: Sergei_varlamov@mail.ru
40 Lenina St., Barnaul 656038; 77 Nikitina St., Barnaul 656049. Russian Federation
A. F. Lazarev
Altai State Medical University, Ministry of Health of Russia; Altai Branch of the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Email: Sergei_varlamov@mail.ru
40 Lenina St., Barnaul 656038; 77 Nikitina St., Barnaul 656049. Russian Federation
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