APHIG: a new multiparameter index for prostate cancer

N. S. Sergeeva; Сергеева Н. С.; T. E. Skachkova; Скачкова Т. Е.; B. Ya. Alekseev; Алексеев Б. Я.; E. F. Yurkov; Юрков Е. Ф.; S. A. Pirogov; Пирогов С. А.; V. G. Gitis; Гитис В. Г.; N. V. Marshutina; Маршутина Н. В.; A. D. Kaprin; Каприн А. Д.

doi:10.17650/1726-9776-2016-12-4-94-103

APHIG: a new multiparameter index for prostate cancer

Authors: Sergeeva N.S.¹^,2, Skachkova T.E.², Alekseev B.Y.¹, Yurkov E.F.³, Pirogov S.A.³, Gitis V.G.³, Marshutina N.V.¹, Kaprin A.D.¹
Affiliations:
1. P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
2. N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
3. Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences
Issue: Vol 12, No 4 (2016)
Pages: 94-103
Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCER
Published: 30.12.2016
URL: https://oncourology.abvpress.ru/oncur/article/view/587
DOI: https://doi.org/10.17650/1726-9776-2016-12-4-94-103
ID: 587

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Abstract

Serum of 336 patients with primary prostate cancer (PC) with baseline total prostate-specific antigen level (totPSA) < 30.0 ng/ml was tested for free PSA (freePSA) and [-2]proPSA; %freePSA, %[-2]proPSA, prostate health index (phi), and a new index APHIG calculated using lab tests and taking into account age, T stage and Gleason score from biopsy were evaluated. Obtained data was compared to tumor stage (pTNM) and malignancy grade according to the Gleason score based on the final histological report after prostatectomy. APHIG has statistically significant benefits compared to PSA-associated markers for differentiation of clinically significant subgroups of PC: pT2c/pT3a/pT3b; local indolent PC/local aggressive/locally advanced/PC with regional metastases; total Gleason score 5–6/7(3 + 4)/7(4 + 3).

Keywords

indolent and aggressive prostate cancer, prostate-specific antigen, totPSA, freePSA, [-2]proPSA, prostate health index

About the authors

N. S. Sergeeva

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: prognoz.01@mail.ru

3 2nd Botkinskiy Proezd, Moscow 125284;

1 Ostrovityanovа St., Moscow 117997

Russian Federation

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