A new alternating regimen in metastatic renal cell carcinoma presented through a clinical case

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Abstract

In the article a new alternating regimen which includes alternation between interferon (INF) immunotherapy and target therapy (sunitinib) is described through a clinical case. Mentions of this type of regimen weren’t found in the literature. As a result of the regimen, treatment efficacy increased due to decreased development of resistance to targeted therapy, cumulative toxicity decreased, synergy between immunotherapy and targeted therapy was achieved, and the cost of the treatment was reduced by 50 %. Considering the above, other alternating regimens can be of interest for researchers: INF/targeted therapies (INF/axitinib, et al.), checkpoint inhibitors/targeted therapies. At the same time, randomized phase II trial ROPETAR showed that alternation of targeted therapies (pazopanib/everolimus) does not increase treatment efficacy or decrease toxicity in comparison with sequential dosing.

About the authors

M. S. Sayapina

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Author for correspondence.
Email: maria.sayapina@mail.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

S. V. Shiryaev

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Email: maria.sayapina@mail.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

A. S. Krylov

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Email: maria.sayapina@mail.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

A. D. Ryzhkov

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

23 Kashirskoe Shosse, Moscow 115478

D. A. Titov

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

23 Kashirskoe Shosse, Moscow 115478

D. A. Nosov

Central Clinical Hospital, Administration of President of Russia

Email: nosov@mail.ru
15 Marshala Timoshenko St., Moscow 121359 Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-36986 от  21.07.2009.