HISTOSPECTROPHOTOMETRICAL AND IMMUNOHISTOCHEMISTRICAL RESEARCH OF RENAL INTRATUBULAR NEOPLASIA IN PERITUMOUROUS ZONE OF A RENAL CARCINOMA

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Abstract

In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations.

About the authors

T. M. Cherdantseva

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Author for correspondence.
Email: drakon@agmu.ru
Russian Federation

I. P. Bobrov

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Email: drakon@agmu.ru
Russian Federation

V. V. Klimachev

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Email: drakon@agmu.ru
Russian Federation

V. M. Brjuhanov

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Email: drakon@agmu.ru
Russian Federation

A. F. Lazarev

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Email: drakon@agmu.ru
Russian Federation

A. M. Avdalyan

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Email: drakon@agmu.ru
Russian Federation

V. Ya. Gervald

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Email: drakon@agmu.ru
Russian Federation

E. I. Sechenev

The Altay state of medical university; The Altay branch GU «The Russian oncological centre of N.N. Blohina» of the Russian Academy of Medical Science, Barnaul

Email: drakon@agmu.ru
Russian Federation

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