Email this article THE CLINICAL AND MORPHOLOGICAL FEATURES OF LATENT PROSTATE CANCER
- Authors: Fedosenko K.V.1, Karlov P.A.1
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Affiliations:
- City Clinical Cancer Dispensary, Saint Petersburg
- Issue: Vol 5, No 3 (2009)
- Pages: 40-43
- Section: PROSTATE CANCER
- Published: 30.09.2009
- URL: https://oncourology.abvpress.ru/oncur/article/view/260
- DOI: https://doi.org/10.17650/1726-9776-2009-5-3-40-43
- ID: 260
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Abstract
The purpose of the study was to provide a retrospective clinicomorphological assessment of the results of examining 70 patients with occult prostate cancer (PC). The findings show it expedient to identify latent prostate cancer as a special clinicomorphological form having a relatively good prognosis. According to the data, surgical or medical antiandrogen blockade had not caused a significant increase in the survival time up to 9 years in these patients and the cause of death was the development of intercurrent diseases rather than tumor progression. Latent cancer is characterized by the following signs:
— detection of only single foci of malignization among a great deal of study tissue pieces) (a tumor in 1—3 out of 20—30 tissue fragments);
— a Gleason score not more than 4;
— detection of Ki-67 in more than 10% of tumor cells;
— the activity of nucleolar organizers up to 3.8;
— a strong reaction to androgen receptors in the majority of tumor cells;
— no p53 hyperexpression;
— a slight or moderate lymphoid or monocytic cell infiltration of the tissues adjacent to the tumor.
The planning of PC management should involve in-depth morphological and molecular genetic analyses.
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About the authors
K. V. Fedosenko
City Clinical Cancer Dispensary, Saint Petersburg
Author for correspondence.
Email: fkvhome@mail.ru
Russian Federation
P. A. Karlov
City Clinical Cancer Dispensary, Saint Petersburg
Email: fkvhome@mail.ru
Russian Federation
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