INTRAVESICAL THERAPY FOR BLADDER CANCER: STATE-OF-THE ART

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Abstract

Intravesical chemo/immunotherapy is a constituent of combination treatment for bladder cancer and widely used after transurethral resection of the tumor. The goal of intravesical therapy is to reduce the risk of a recurrence and progression of the disease, by exerting a direct cytotoxic effect on malignancy. The unique properties of the bladder make it possible to constantly improve the existing local therapy options and to develop novel ones, such as intravesical electrophoresis, local hyperthermia, gene therapy, and the use of penetrants and magnetic particles. The given review combines the physicochemical and pharmacokinetic properties of drugs, the histoarchitectonic features of the bladder, the present and future of intravesical therapy.

About the authors

V. V. Protoshchak

Department of Urology, S.M. Kirov Military Medical Academy

Author for correspondence.
Email: protoshakurology@mail.ru
Russian Federation

A. V. Kukushkin

Department of Urology, S.M. Kirov Military Medical Academy

Email: protoshakurology@mail.ru
Russian Federation

P. A. Babkin

Department of Urology, S.M. Kirov Military Medical Academy

Email: protoshakurology@mail.ru
Russian Federation

A. Yu. Shestayev

Department of Urology, S.M. Kirov Military Medical Academy

Email: protoshakurology@mail.ru
Russian Federation

N. D. Kubin

Department of Urology and Andrology, Saint Petersburg Medical Academy of Postgraduate Education, Saint Petersburg

Email: protoshakurology@mail.ru
Russian Federation

E. S. Shpilenya

Department of Urology and Andrology, Saint Petersburg Medical Academy of Postgraduate Education, Saint Petersburg

Email: protoshakurology@mail.ru
Russian Federation

A. I. Novikov

Department of Urology and Andrology, Saint Petersburg Medical Academy of Postgraduate Education, Saint Petersburg

Email: protoshakurology@mail.ru
Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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