HUMAN PLASMA PROTEOME MAPPING IN HEALTH AND CLEAR CELL CARCINOMA OF THE KIDNEY

V. E. Shevchenko; Шевченко В. Е.; S. V. Kovalev; Ковалев С. В.; V. A. Yurchenko; Юрченко В. А.; V. B. Matveev; Матвеев В. Б.; D. G. Zaridze; Заридзе Д. Г.

doi:10.17650/1726-9776-2011-7-3-65-69

HUMAN PLASMA PROTEOME MAPPING IN HEALTH AND CLEAR CELL CARCINOMA OF THE KIDNEY

Authors: Shevchenko V.E.¹, Kovalev S.V.¹, Yurchenko V.A.¹, Matveev V.B.¹, Zaridze D.G.¹
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Issue: Vol 7, No 3 (2011)
Pages: 65-69
Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER
Published: 30.09.2011
URL: https://oncourology.abvpress.ru/oncur/article/view/236
DOI: https://doi.org/10.17650/1726-9776-2011-7-3-65-69
ID: 236

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Abstract

Plasma proteome from patients with renal cell carcinoma (RCC) and controls underwent mass spectrometric mapping. A total of 247 proteins were identified; the expression of 12 proteins of them increased on transition from the controls to patients with Stages I–II and III–IV RCC. There was decreased expression of 14 proteins in this series. Out of the 26 proteins showing a change in their expressions, 7 proteins belong to acute-phase ones, 3 proteins are associated with the intercellular matrix. These proteins can be potential markers for RCC.

Keywords

renal cell carcinoma, mass spectrometry, proteomic markers

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HUMAN PLASMA PROTEOME MAPPING IN HEALTH AND CLEAR CELL CARCINOMA OF THE KIDNEY

Full Text

Abstract

Keywords

About the authors

V. E. Shevchenko

S. V. Kovalev

V. A. Yurchenko

V. B. Matveev

D. G. Zaridze

References

Supplementary files