ANALYSIS OF COMPLICATIONS DUE TO INTRATISSUE RADIOTHERAPY USING CONSTANT SOURCES IN PATIENTS WITH PROSTATE CANCER

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Abstract

Brachytherapy is a standard treatment for localized advanced prostate cancer (PC). Complications due to interstitial radiotherapy using permanent sources were analyzed in 149 patients. The incidence of early grade 3 radiation urethritis was 7.4 % and that of rectitis was 3.4%. Late radiation urethritis and rectitis were recorded in 3.4 and 0.7 %, respectively. Sexual function 12 months later was preserved in 86.6 % of the patients. Studies established no statistically significant factors that influenced the frequency of complications. The patients with a prostate volume of > 50 cm3, a preoperative international prostate symptom score of > 15, a urine flow rate of < 15 ml/min, and urethral and
rectal radiation doses of > 210 and > 180 Gy, respectively, tended to have more common radiation reactions. Thus, brachytherapy is a reasonably safe treatment for PC.

About the authors

A. V. Petrovsky

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Author for correspondence.
Email: alexpetrovsky@hotmail.com
Russian Federation

B. V. Bukharkin

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Email: alexpetrovsky@hotmail.com
Russian Federation

V. N. Sholokhov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Email: alexpetrovsky@hotmail.com
Russian Federation

D. A. Roshchin

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Email: alexpetrovsky@hotmail.com
Russian Federation

V. B. Matveyev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Email: alexpetrovsky@hotmail.com
Russian Federation

M. I. Nechushkin

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Email: alexpetrovsky@hotmail.com
Russian Federation

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