Cognizance and adherence to outpatient treatment in patients with prostate cancer after local treatment: multicenter study

Vladimir M. Perepukhov; Перепухов Владимир Максимович; K. M. Nyushko; Нюшко К. М.; B. Ya. Alekseev; Алексеев Б. Я.; I. M. Shevchuk; Шевчук И. М.; V. P. Aleshin; Алешин В. П.; N. D. Movchan; Мовчан Н. Д.; O. A. Mailyan; Маилян О. А.; R. L. Sugaipov; Сугаипов Р. Л.; F. Sh. Mangutov; Мангутов Ф. Ш.; V. A. Biryukov; Бирюков В. А.; E. O. Shchukina; Щукина Е. О.; A. Yu. Pavlov; Павлов А. Ю.; A. G. Dzidzaria; Дзидзария А. Г.; A. D. Tsibulskii; Цыбульский А. Д.; A. D. Fedotova; Федотова А. Д.; I. P. Moshurov; Мошуров И. П.; D. Yu. Kamenev; Каменев Д. Ю.; A. A. Zayniddinov; Зайниддинов А. А.; A. Yu. Cherkasova; Черкасова А. Ю.; A. A. Keln; Кельн А. А.; A. V. Ratobolskikh; Ратобольских А. В.; A. V. Kupchin; Купчин А. В.; N. Yu. Borodina; Бородина Н. Ю.; R. V. Nikitin; Никитин Р. В.; K. Yu. Kanukoev; Канукоев К. Ю.; N. D. Glushankova; Глушанкова Н. Д.; E. A. Kipriyanov; Киприянов Е. А.; A. A. Lozhkov; Ложков А. А.; V. V. Remizov; Ремизов В. В.; D. V. Tevs; Тевс Д. В.; R. Yu. Kovalenko; Коваленко Р. Ю.; E. V. Ozornin; Озорнин Е. В.

doi:10.17650/1726-9776-2025-21-4-47-58

Cognizance and adherence to outpatient treatment in patients with prostate cancer after local treatment: multicenter study

Authors: Perepukhov V.M.¹, Nyushko K.M.¹^,2, Alekseev B.Y.²^,1, Shevchuk I.M.¹, Aleshin V.P.¹, Movchan N.D.¹, Mailyan O.A.¹, Sugaipov R.L.¹, Mangutov F.S.¹, Biryukov V.A.¹, Shchukina E.O.¹, Pavlov A.Y.³, Dzidzaria A.G.³, Tsibulskii A.D.³, Fedotova A.D.³, Moshurov I.P.⁴, Kamenev D.Y.⁴, Zayniddinov A.A.⁴, Cherkasova A.Y.⁴, Keln A.A.⁵, Ratobolskikh A.V.⁵, Kupchin A.V.⁵, Borodina N.Y.⁵, Nikitin R.V.⁶, Kanukoev K.Y.⁷, Glushankova N.D.⁸, Kipriyanov E.A.⁸, Lozhkov A.A.⁸, Remizov V.V.⁹, Tevs D.V.¹⁰, Kovalenko R.Y.¹⁰, Ozornin E.V.¹⁰
Affiliations:
1. National Medical Research Radiological Center, Ministry of Health of Russia
2. Russian Biotechnological University
3. Russian Scientific Center of Roentgenoradiology, Ministry of Health of Russia
4. Voronezh Regional Scientific and Clinical Oncology Dispensary
5. Multidisciplinary Clinical Medical Center “Medical City”
6. Clinical Oncological Dispensary No. 1, Ministry of Health of Krasnodar District, Krasnodar
7. Oncology Dispensary, Ministry of Health of the Kabardino-Balkarian Republic, Nalchik
8. Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
9. Samara Regional Clinical Oncological Dispensary
10. Sverdlovsk Regional Clinical Hospital No. 1, Yekaterinburg
Issue: Vol 21, No 4 (2025)
Pages: 47-58
Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCER
Published: 27.02.2026
URL: https://oncourology.abvpress.ru/oncur/article/view/1976
DOI: https://doi.org/10.17650/1726-9776-2025-21-4-47-58
ID: 1976

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Abstract

Background. Prostate cancer is the most common cancer among men in Russia. Despite the successes of local treatment, the risk of biochemical recurrence (BR) persists and requires long-term monitoring of prostate-specific antigen (PSA). Patient compliance is a crucial factor of timely recurrence diagnosis.

Aim. To evaluate cognizance and adherence to outpatient treatment in patients with local and locally advanced prostate cancer after local treatment in Russia.

Materials and methods. Two-stage study was performed: survey of 22 oncologists from 18 centers and telephone survey of 2046 patients from 10 oncological centers who received local treatment in 2022. Original questionnaires were used. Statistical analysis was performed using the Statistica 10 software.

Results. The majority of patients (99.2 %) are informed about the necessity of PSA level monitoring. However, 36.8 % did not know threshold PSA levels, 18.7 % did not undergo examination in a timely manner, and 4.3 % weren’t informed on the timeframes of monitoring. BR was diagnosed in 11.43 % of patients. Among them, in 16.2 % clinical recurrence was detected due to late BR diagnostics and belated visit to an oncologist. However, no statistically significant correlation between cognizance level, examination regularity with development of clinical recurrence was found (p >0.05). In 39.3 % of cases, treatment of prostate cancer due to diagnosed BR was delayed.

Conclusion. Despite high general cognizance, significant deficit of practical knowledge and low adherence to regular monitoring were observed. To decrease the number of clinical recurrences developed due to delayed start of treatment after BR, comprehensive approach is necessary consisting of patient briefing and optimization of control methods at the medical facilities performing outpatient observation.

Keywords

prostate cancer, outpatient treatment, compliance, cognizance, examination, recurrence

About the authors

Vladimir M. Perepukhov

National Medical Research Radiological Center, Ministry of Health of Russia

Author for correspondence.
Email: alfarvp05@gmail.com
ORCID iD: 0000-0001-7280-2553

N.A. Lopatkin Research Institute of Urology and Interventional Radiology

Russian Federation, Build. 1, 51 3rd Parkovaya St., Moscow 105425

K. M. Nyushko

National Medical Research Radiological Center, Ministry of Health of Russia; Russian Biotechnological University

Email: alfarvp05@gmail.com
ORCID iD: 0000-0002-4171-6211

N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center, Ministry of Health of Russia; Medical Institute of Continuing Education, Russian Biotechnological University

Russian Federation, Build. 1, 51 3rd Parkovaya St., Moscow 105425; 11 Volokolamskoe Shosse, Moscow 125080

B. Ya. Alekseev

Russian Biotechnological University; National Medical Research Radiological Center, Ministry of Health of Russia

Email: alfarvp05@gmail.com
ORCID iD: 0000-0002-3398-4128

Medical Institute of Continuing Education, Russian Biotechnological University

Russian Federation, 11 Volokolamskoe Shosse, Moscow 125080; 3 2nd Botkinskiy Proezd, Moscow 125284

I. M. Shevchuk

National Medical Research Radiological Center, Ministry of Health of Russia

Email: alfarvp05@gmail.com
ORCID iD: 0000-0002-6877-0437

N.A. Lopatkin Research Institute of Urology and Interventional Radiology

Russian Federation, Build. 1, 51 3rd Parkovaya St., Moscow 105425

V. P. Aleshin

National Medical Research Radiological Center, Ministry of Health of Russia

Email: alfarvp05@gmail.com
ORCID iD: 0000-0002-0152-5525

N.A. Lopatkin Research Institute of Urology and Interventional Radiology

Russian Federation, Build. 1, 51 3rd Parkovaya St., Moscow 105425

N. D. Movchan

National Medical Research Radiological Center, Ministry of Health of Russia

Email: alfarvp05@gmail.com
ORCID iD: 0009-0008-5724-4555

N.A. Lopatkin Research Institute of Urology and Interventional Radiology

Russian Federation, Build. 1, 51 3rd Parkovaya St., Moscow 105425

A.F. Tsyb Medical Radiological Research Center

Russian Federation, 4 Koroleva St., Obninsk 249031

E. O. Shchukina

National Medical Research Radiological Center, Ministry of Health of Russia

Email: alfarvp05@gmail.com
ORCID iD: 0000-0001-5431-8696

A.F. Tsyb Medical Radiological Research Center

Russian Federation, 4 Koroleva St., Obninsk 249031

References

State of oncological care in Russia in 2024. Eds.: А.D. Kaprin, V.V. Starinskiy, A.O. Shachzadova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2025. 275 p. (In Russ.).
Zahed H., Feng X., Sheikh M. et al. Age at diagnosis for lung, colon, breast and prostate cancers: an international comparative study. Int J Cancer 2024;154(1):28–40. doi: 10.1002/ijc.34671
Bleyer A., Spreafico F., Barr R. Prostate cancer in young men: an emerging young adult and older adolescent challenge. Cancer 2020;126(1):46–57. doi: 10.1002/cncr.32498
Nosov D.A., Volkova M.I., Gladkov O.A. et al. Prostate cancer. Zlokachestvennye opukholi = Malignant Tumors 2024;14(3s2-2):242–66. (In Russ.). doi: 10.18027/2224-5057-2024-14-3s2-1.2-10
Freedland S.J., Humphreys E.B., Mangold L.A. et al. Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. JAMA 2005;294(4):433–9. doi: 10.1001/jama.294.4.433
Kupelian P.A., Buchsbaum J.C., Elshaikh M. et al. Factors affecting recurrence rates after prostatectomy or radiotherapy in localized prostate carcinoma patients with biopsy Gleason score 8 or above. Cancer 2002;95:2302–7.
Nedurueva T.V., Pavlova L.E., Stoyanov L.V. Bibliometric and conceptual and categorical analysis of the problem of compliance in medical psychology. Regionalniy vestnik = Regional Herald 2020;(4):71–2. (In Russ.).
Baova A.B., Suvorina O.V., Fakhrudiniva E.R. Compliance as a prerequisite for treatment efficacy. Bulleten meditsinskikh internet konferentsiy. Nauka i innovatsii = Bulletin of Medical Internet Conferences. Science and Innovations 2015;5(12):1541.(In Russ.).
Official site of the State Duma of the Federal Assembly of the Russian Federation. Available at: http://duma.gov.ru/news/55815/ (accessed on 24.09.2025). (In Russ.).

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