HIGH-RISK PROSTATE CANCER: THE ONCOLOGICAL EFFICIENCY OF RADICAL PROSTATECTOMY

Patients with high-risk prostate cancer (PC) make up a heterogeneous population who has a substantially varying benefit from surgical treatment. The long-term oncological results of radical prostatectomy (RPE) were studied in 446 high D’Amico-risk PC patients. Overall 5- and 10-year relapse-free survival (RFS) rates were 65 and 62 %; overall 10- and 15-year cancer-specific survival (CSS) rates were 92.6 and 82.6 %. Patients with the completely removed tumor located in the histologic specimen (HS) benefited most greatly from RPE. In the HS located and unlocated tumor groups, 5-year RFS rates were 79.6 and 32.7 %; 10-year CSS rates were equal to 100 and 78.6 %. The number of preoperative high risk factors had a significant impact on outcomes. In the 1, 2, and 3 risk factor groups, 5-year RFS rates were 76.7, 39, and 35.3 % and 10-year CSS rates were equal to 97.8, 85.4, and 64.2 %, respectively.