Prognostic factors affecting survival of patients with penile cancer receiving treatment in wide clinical practice

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Abstract

Aim. To evaluate the effect of prognostic factors on survival rates of patients with penile cancer and to identify groups of patients with favorable and unfavorable prognoses.

Materials and methods. Retrospective analysis of data of 197 patients with penile cancer who were treated at the Moscow City Oncological Hospital No. 62 and Clinical Oncological Dispensary (Omsk) between 1997 and 2023 was performed.

Results. Statistically significant prognostic factors affecting survival rates of patients with penile cancer according to univariate analysis (log-rank test with p <0.05) and multivariate Cox regression analysis are: clinical stage (I–IV), T stage (T1–T3), resection margin (R0–R1), N grade (N0–N3), lymphovascular invasion, extranodal extension of metastasis to the inguinal lymph nodes, necrosis of the primary tumor, iliac lymph node involvement. Factors without significant effect on survival are: morphological structure of the tumor (p = 0.73), radiation therapy of the primary tumor (p = 0.38), chemotherapy (p = 0.46).

Conclusion. Analysis of clinical and pathomorphological factors allowed to identify an unfavorable prognosis group in patients with penile cancer for a personalized approach to improve survival rates.

About the authors

V. I. Shirokorad

Moscow City Oncological Hospital No. 62, Moscow Healthcare Department

ORCID iD: 0000-0003-4109-6451

27 Istra, Moscow Region 143515

Russian Federation

S. V. Kostritskiy

Moscow City Oncological Hospital No. 62, Moscow Healthcare Department

Author for correspondence.
Email: Stas.medic@bk.ru
ORCID iD: 0000-0003-4494-1489

 Stanislav V. Kostritskiy

27 Istra, Moscow Region 143515

Russian Federation

D. V. Semenov

Saint Petersburg State University;
City Clinical Oncological Dispensary

ORCID iD: 0000-0002-4335-8446

7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034,

56 Prospekt Veteranov, Saint Petersburg 198255

Russian Federation

D. D. Yakubova

Moscow City Oncological Hospital No. 62, Moscow Healthcare Department

ORCID iD: 0000-0002-6783-9519

27 Istra, Moscow Region 143515

Russian Federation

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