Undifferentiated pleomorphic prostate sarcoma: a rare clinical case and systematic literature review

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Abstract

Undifferentiated pleomorphic prostate sarcoma is an extremely rare neoplasm. In the available literature, less than 50 clinical cases were described. Usually, the clinical manifestation of the disease is nonspecific and is primarily associated with bladder outlet obstruction. Additionally, most patients have normal levels of prostate-specific antigen, while ultrasound and MRI can visualize irregularly shaped lesions, often extending beyond the prostate gland. Diagnosis requires exclusion of other signs of specific differentiation, apart from fibroblastic and myofibroblastic. There is no established treatment plan for patients with pleomorphic prostate sarcoma due to extreme rarity of the disease. For localized forms of the disease, radical laparoscopic prostatectomy is often used, but more aggressive treatment options are also being considered, including total pelvic exenteration, chemotherapy and radiation therapy. However, in most cases metastasis is revealed after primary treatment. Regional metastases are often localized in the rectum, bladder, in the area of previous surgery, and regional lymph nodes, while distant metastases are found in the lungs, liver, bones and distant lymph nodes, thereby indicating aggressive progression and poor prognosis of the disease.

In this article, we present our own clinical observation of a patient with confirmed undifferentiated pleomorphic prostate sarcoma.

About the authors

N. I. Sorokin

Lomonosov Moscow State University; Medical Scientific and Educational Center, Lomonosov Moscow State University

ORCID iD: 0000-0001-9466-7567

1 Leninskie Gory, Moscow 119991; Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234

Russian Federation

V. K. Dzitiev

Medical Scientific and Educational Center, Lomonosov Moscow State University

ORCID iD: 0000-0001-7558-589X

Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234

Russian Federation

A. V. Kadrev

Medical Scientific and Educational Center, Lomonosov Moscow State University; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

ORCID iD: 0000-0002-6375-8164

Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234; Build. 1, 2/1 Barrikadnaya St., Moscow 125993

Russian Federation

N. V. Danilova

Lomonosov Moscow State University; Medical Scientific and Educational Center, Lomonosov Moscow State University

ORCID iD: 0000-0001-7848-6707

1 Leninskie Gory, Moscow 119991; Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234

Russian Federation

O. Yu. Nesterova

Lomonosov Moscow State University; Medical Scientific and Educational Center, Lomonosov Moscow State University

Author for correspondence.
Email: oy.nesterova@gmail.com
ORCID iD: 0000-0003-3355-4547

Ol’ga Yu. Nesterova.

1 Leninskie Gory, Moscow 119991; Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234

Russian Federation

A. A. Strigunov

Lomonosov Moscow State University; Medical Scientific and Educational Center, Lomonosov Moscow State University

ORCID iD: 0000-0003-4518-634X

1 Leninskie Gory, Moscow 119991; Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234

Russian Federation

D. A. Tsigura

Lomonosov Moscow State University

ORCID iD: 0000-0002-0512-3152

1 Leninskie Gory, Moscow 119991

Russian Federation

E. V. Afanas’evskaya

Lomonosov Moscow State University; Medical Scientific and Educational Center, Lomonosov Moscow State University; Istra Clinical Hospital

ORCID iD: 0000-0002-0161-6072

1 Leninskie Gory, Moscow 119991; Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234; 83 Uritskogo St., Istra, Moscow Region 143500

Russian Federation

E. A. Gallyamov

Medical Scientific and Educational Center, Lomonosov Moscow State University

ORCID iD: 0000-0002-6359-0998

Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234

Russian Federation

A. A. Kamalov

Lomonosov Moscow State University; Medical Scientific and Educational Center, Lomonosov Moscow State University

ORCID iD: 0000-0003-4251-7545

1 Leninskie Gory, Moscow 119991; Build. 10, 27 Lomonosovskiy Prospekt, Moscow 119234

Russian Federation

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