The role of obesity in patients with renal cell carcinoma

I. B. Kravtsov; Кравцов И. Б.; V. A. Solodky; Солодкий В. А.; A. Yu. Pavlov; Павлов А. Ю.; A. G. Dzidzaria; Дзидзария А. Г.; S. V. Fastovets; Фастовец С. В.; I. V. Khoroshevskaya; Хорошевская И. В.

doi:10.17650/1726-9776-2023-19-1-17-24

The role of obesity in patients with renal cell carcinoma

Authors: Kravtsov I.B.¹, Solodky V.A.¹, Pavlov A.Y.¹, Dzidzaria A.G.¹, Fastovets S.V.¹, Khoroshevskaya I.V.¹
Affiliations:
1. Russian Scientific Center of Roentgenradiology, Ministry of Health of Russia
Issue: Vol 19, No 1 (2023)
Pages: 17-24
Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER
Published: 13.05.2023
URL: https://oncourology.abvpress.ru/oncur/article/view/1632
DOI: https://doi.org/10.17650/1726-9776-2023-19-1-17-24
ID: 1632

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Abstract

Renal cell carcinoma is one of the most common malignant neoplasms of the genitourinary system. Along with smoking and hereditary syndromes associated with mutations in the Von Hippel-Lindau (VHL) gene, obesity is one of the main risk factors for the development of renal cell carcinoma. Emerging data indicate a causal relationship between obesity and development of renal cell carcinoma. In a large study within the framework of the Metabolic Syndrome and Cancer project, clinical data on blood pressure, body mass index, blood glucose, cholesterol and triglycerides were collected in 560,388 people. Individually, high glucose and triglyceride levels, as well as high body mass index and blood pressure, correlated with an increased risk of renal cell carcinoma in men, while only body mass index had a significant correlation in women.