Partial and complete spontaneous regression of testicular seminoma: clinical cases

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Abstract

Spontaneous tumour regression is a rare phenomenon in which there is a complete or partial regression of the primary tumour, clinically manifested by metastatic lesions. We report a case of a 34-year-old male with partial spontaneous regression of testicular seminoma detected by a supraclavicular lymph node biopsy. He underwent inguinal orchifunicolectomy. Based on the results of histological examination, against the background of multiple complexes of intratubular germ cell neoplasia in situ, foci of invasive growth and involution were identified, indicating a spontaneously regressing testicular tumour. We report the second case of a 52-year-old male with total spontaneous regression of testicular seminoma detected by a spermatic cord biopsy. Based on the results of histological examination, against fibrosis and proliferation of Leydig cells, there are atrophy of seminiferous tubules and complexes of intratubular germ cell neoplasia in situ in part of them.

About the authors

V. S. Surkova

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Author for correspondence.
Email: sidorencko.tori@gmail.com
ORCID iD: 0000-0002-2674-0416

Viktoriya Sergeevna Surkova

3 2nd Botkinskiy Proezd, Moscow 125284

Russian Federation

N. N. Volchenko

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: mnioict@mail.ru
ORCID iD: 0000-0002-4873-4455

3 2nd Botkinskiy Proezd, Moscow 125284

Russian Federation

V. A. Burakova

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: bur.va06@gmail.com
ORCID iD: 0000-0001-8968-360X

3 2nd Botkinskiy Proezd, Moscow 125284

Russian Federation

A. M. Lavrova

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: anastasia.lavrova96@yandex.ru
ORCID iD: 0000-0002-8668-6108

3 2nd Botkinskiy Proezd, Moscow 125284

Russian Federation

F. S. Ashirova

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: fidan_samirovna@bk.ru
ORCID iD: 0000-0002-1152-0058

3 2nd Botkinskiy Proezd, Moscow 125284; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

G. G. Khakimova

Tashkent City Branch, Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology; Department of Oncology, Pediatric Oncology, Tashkent Pediatric Medical Institute

ORCID iD: 0000-0002-4970-5429

Department of Oncology, Pediatric Oncology, TPMI.

1 Bogiston St., Tashkent 100070; 223 Bogishamol St., Tashkent 100140

Uzbekistan

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